Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
330 South 9th Street
Philadelphia, PA 19107
A facility of Pennsylvania Hospital
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Development of α-synuclein and amyloid-β biomarkers for Parkinson's disease and related neurodegenerative diseases.
Akhtar RS, Licata JP, Luk KC, Shaw LM, Trojanowski JQ, Lee VM.: Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease. Journal of Neurochemistry 145 (6): 489-503,2018.
Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin AS, Duda JE, Spindler M, Siderowf AD, Hurtig HI, Shaw LM, Grossman M, Trojanowski JQ: CSF tau and amyloid-β predict cerebral synucleinopathy in autopsied Lewy Body disorders. Neurology
90 (12): e1038-e1046,2018.
Akhtar RS, Licata JP, Luk KC, Covell DJ, Trojanowski JQ, Lee VM: Epitope mapping of CSF auto-antibodies to α-synuclein. Movement Disorders 32 (suppl 2): S231,2017.
Akhtar RS, Xie SX, Chen YJ, Rick J, Gross RG, Nasrallah IM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS, Hurtig HI, Siderowf AD, Dubroff JG, Weintraub D: Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia. PLoS One 12 (5): e0177924,2017.
Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, and Lee VM: Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson’s disease. Neuropathology and Applied Neurobiology 43 (7): 604-620,2017.
Akhtar RS, Xie SX, Brennan L, Pontecorvo MJ, Hurtig HI, Trojanowski JQ, Weintraub D, and Siderowf AD: Amyloid-β PET imaging of Alzheimer pathology in Parkinson disease dementia. Movement Disorders Clinical Practice 3 (4): 367-375,2016.
Pigott K, Rick J, Xie SX, Hurtig HI, Chen-Plotkin AS, Duda JE, Morley JF, Chahine LM, Dahodwala N, Akhtar RS, Siderowf AD, Trojanowski JQ, and Weintraub D: Longitudinal study of normal cognition in Parkinson’s Disease. Neurology 85 (15): 1276-1282,2015.
Akhtar RS, Stern MB: New concepts in the early and preclinical detection of Parkinson's disease: therapeutic implications. Expert Review of Neurotherapeutics 12 (12): 1429-1438,2012.
Akhtar RS, Horn SS: Psychiatric manifestations of common neurologic disorders. Principles and Practice of Geriatric Psychiatry 2 ed : 735-744,2011.
Akhtar RS, Latham CB, Siniscalco D, Fuccio C, Roth KA: Immunohistochemical detection with quantum dots. Methods in Molecular Biology 374 : 11-28,2007.
Akhtar RS, Klocke BJ, Strasser A, Roth KA: Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice. Journal of Histochemistry and Cytochemistry 56 (10): 921-927,2008.
Akhtar RS, Roth KA: Regulation of neural stem cell death. Neural Development and Stem Cells 2 ed. : 97-122,2006.
Akhtar RS, Geng Y, Klocke BJ, Latham CB, Villunger A, Michalak EM, Strasser A, Carroll SL, Roth KA: BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. The Journal of Neuroscience 26 (27): 7257-7264,2006.
Akhtar RS, Geng Y, Klocke BJ, Roth KA: Neural precursor cells possess multiple p53-dependent apoptotic pathways. Cell Death and Differentiation 13 (10): 1727-1739,2006.
Akhtar RS, Ness JM, Roth KA: Bcl-2 family regulation of neuronal development and neurodegeneration. Biochimica et Biophysica Acta 1644 (2-3): 189-203,2004.
Ness JM, Akhtar RS, Latham CB, Roth KA: Combined tyramide signal amplification and quantum dots for sensitive and photostable immunofluorescence detection. Journal of Histochemistry and Cytochemistry 51 (8): 981-987,2003.
330 South 9th St, Fourth FloorPenn Medicine Pennsylvania Hospital
Phone: (215) 829-6500
Patient appointments: 800-789-7366