Description of Research Expertise:
Development of α-synuclein and amyloid-β biomarkers for Parkinson's disease and related neurodegenerative diseases.
Akhtar RS, Licata JP, Luk KC, Covell DJ, Trojanowski JQ: Epitope mapping of CSF auto-antibodies to α-synuclein. Movement Disorders : 2017.
Akhtar RS, Xie SX, Chen YJ, Rick J, Gross RG, Nasrallah IM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS, Hurtig HI, Siderowf AD, Dubroff JG: Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia. PLoS One 12 (5): 2017.
Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ: Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson’s disease. Neuropathology and Applied Neurobiology : 2017.
Akhtar RS, Xie SX, Brennan L, Pontecorvo MJ, Hurtig HI, Trojanowski JQ, Weintraub D: Amyloid-β PET imaging of Alzheimer pathology in Parkinson disease dementia. Movement Disorders Clinical Practice 3 (4): 367-375,2016.
Akhtar RS, Luk KC, Trojanowski JQ: Auto-antibodies to α-synuclein are present in Parkinson Disease biofluids. Movement Disorders 30 (suppl 1): S28,2015.
Pigott K, Rick J, Xie SX, Hurtig HI, Chen-Plotkin AS, Duda JE, Morley JF, Chahine LM, Dahodwala N, Akhtar RS, Siderowf AD, Trojanowski JQ: Longitudinal study of normal cognition in Parkinson’s Disease. Neurology 85 (15): 1276-1282,2015.
Akhtar RS: New concepts in the early and preclinical detection of Parkinson's disease: therapeutic implications. Expert Review of Neurotherapeutics 12 (12): 1429-1438,2012.
Akhtar RS: Psychiatric manifestations of common neurologic disorders. Principles and Practice of Geriatric Psychiatry 2 ed : 735-744,2011.
Akhtar RS, Latham CB, Siniscalco D, Fuccio C: Immunohistochemical detection with quantum dots. Methods in Molecular Biology 374 : 11-28,2007.
Akhtar RS, Klocke BJ, Strasser A: Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice. Journal of Histochemistry and Cytochemistry 56 (10): 921-927,2008.
Akhtar RS: Regulation of neural stem cell death. Neural Development and Stem Cells 2 ed. : 97-122,2006.
Akhtar RS, Geng Y, Klocke BJ, Latham CB, Villunger A, Michalak EM, Strasser A, Carroll SL: BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. The Journal of Neuroscience 26 (27): 7257-7264,2006.
Akhtar RS, Geng Y, Klocke BJ: Neural precursor cells possess multiple p53-dependent apoptotic pathways. Cell Death and Differentiation 13 (10): 1727-1739,2006.
Akhtar RS, Ness JM: Bcl-2 family regulation of neuronal development and neurodegeneration. Biochimica et Biophysica Acta 1644 (2-3): 189-203,2004.
Ness JM, Akhtar RS, Latham CB: Combined tyramide signal amplification and quantum dots for sensitive and photostable immunofluorescence detection. Journal of Histochemistry and Cytochemistry 51 (8): 981-987,2003.
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