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Raymond Soccio, MD, PHD

Raymond Soccio, MD, PHD Physician

Assistant Professor of Medicine

Dr. Soccio is employed by Penn Medicine.

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Clinical Specialties


  • Diabetes
  • Endocrinology

Programs & Centers:

Board Certification:

  • Endocrinology, Diabetes, & Metabolism, 2010

Clinical Expertise:

  • Abnormal Glucose Metabolism
  • Achondroplasia
  • Addison's Disease
  • Adrenal Adenoma
  • Adrenal Gland Disorders
  • Adrenal Mass
  • Adrenal Nodules
  • Adrenogenital Syndrome
  • Androgen Excess
  • Androgen Insensitivity
  • Calcium Metabolism
  • Carcinoid Syndrome
  • Chronic Thyroiditis (Hashimoto's Disease)
  • Congenital Adrenal Hyperplasia
  • Congenital Hypothyroidism
  • Conn Syndrome
  • Cushing's Disease
  • Diabetes
  • Diabetes Education
  • Disorders of Sexual Differentiation
  • Ectopic Hyperparathyroidism
  • Endocrine Disorders
  • Familial Hyperparathyroidism
  • Familial Hypocalciuric Hypercalcemia
  • Feminizing Syndrome
  • Glucagonoma
  • Glucocorticoid Deficiency
  • Goiter
  • Graves' Disease
  • Growth Disorders
  • Growth Hormone Abnormalities
  • Gynecomastia
  • Hyperaldosteronism
  • Hypercalcemia
  • Hyperglycemia
  • Hyperparathyroidism
  • Hyperthyroidism (Overactive Thyroid)
  • Hypocalcemia
  • Hypoglycemia
  • Hypogonadism
  • Hypoparathyroidism
  • Hypopituitarism
  • Hypothalamic-Pituitary Disorder
  • Hypothyroidism (Underactive Thyroid)
  • Insulin Pump
  • Insulin Resistance
  • Insulinoma
  • Metabolic Bone Diseases
  • Metabolic Syndrome
  • Moon Facies
  • Multiple Endocrine Neoplasia
  • Myxedema
  • Nodular Goiter
  • Nontoxic Goiter
  • Osteopenia
  • Osteoporosis
  • Panhypopituitarism
  • Parathyroid Disease
  • Parathyroid Hyperplasia
  • Pheochromocytoma
  • Pituitary Adenoma
  • Pituitary Dwarfism
  • Pituitary Gland Disorders
  • Pituitary Tumors
  • Polyglandular Autoimmune Syndrome
  • Pseudohermaphroditism
  • Pseudohypoparathyroidism
  • Radioactive Iodine (Radioiodine) Therapy
  • Rickets
  • Secondary Hyperaldosteronism
  • Silent Thyroiditis
  • Thyroid Cyst
  • Thyroid Disorders
  • Thyroid Nodule Biopsy
  • Thyroid Nodules
  • Thyrotoxic Exophthalmos
  • Thyrotoxicosis
  • Toxic Diffuse Goiter
  • Toxic Nodular Goiter
  • Type 1 Diabetes
  • Type 2 Diabetes
  • Vitamin D Deficiency
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Weill Medical College of Cornell University
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Diabetes Association, National Department of Defense Congressionally Directed Medical Research Programs(CDMRP), National Philadelphia Endocrine Society, Local The Endocrine Society, International

Hospital Affiliation

Dr. Soccio is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Nuclear Receptors, Genetics of Gene Regulation, Lipid Metabolism

Selected Publications:

Yachen Shen, Yvonne Su, Angela Weller, Raymond Soccio: PPARα and PPARγ gene regulation in brown fat thermogenesis Cold Spring Harbor Mechanisms of Metabolic Signalling Meeting, NY : 2019.

Kiara K. Benson, Wenxiang Hu, Angela H. Weller, Alexis H. Bennett, Eric R. Chen, Sumeet A. Kheterpal, Satoshi Yoshino, Wang L, Joshua D. Rabinowitz, Benjamin F. Voight, Mitchell A. Lazar, Raymond E. Soccio: Natural Genetic Variation in Humans Determines Basal and Inducible Expression of PM20D1, a Putative Thermogenic Gene Endocrine Society Annual Meeting, New Orleans, LA : 2019.

Hu Wenxiang, Jiang Chunjie, Guan Dongyin, Dierickx Pieterjan, Zhang Rong, Moscati Arden, Nadkarni Girish N, Steger David J, Loos Ruth J F, Hu Cheng, Jia Weiping, Soccio Raymond E, Lazar Mitchell A: Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. Cell stem cell 24 (2): 299-308.e6,2019.

Zhang Xuan, Xue Chenyi, Lin Jennie, Ferguson Jane F, Weiner Amber, Liu Wen, Han Yumiao, Hinkle Christine, Li Wenjun, Jiang Hongfeng, Gosai Sager, Hachet Melanie, Garcia Benjamin A, Gregory Brian D, Soccio Raymond E, Hogenesch John B, Seale Patrick, Li Mingyao, Reilly Muredach P: Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of in adipocyte metabolism. Science translational medicine 10 (446): 2018.

Angela H Weller, Kiara Benson, Arya Nakhe, Ioana Soatia, Yachen Shen, Raymond E Soccio: The Role of PPARα in Non-Alcoholic Fatty Liver Disease FASEB meeting "Fundamental Biology and Pathophysiology of the Liver", Scottsdale, AZ : 2018.

Soccio Raymond E, Li Zhenghui, Chen Eric R, Foong Yee Hoon, Benson Kiara K, Dispirito Joanna R, Mullican Shannon E, Emmett Matthew J, Briggs Erika R, Peed Lindsey C, Dzeng Richard K, Medina Carlos J, Jolivert Jennifer F, Kissig Megan, Rajapurkar Satyajit R, Damle Manashree, Lim Hee-Woong, Won Kyoung-Jae, Seale Patrick, Steger David J, Lazar Mitchell A: Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. The Journal of clinical investigation 127 (4): 1451-1462,2017.

Luo Xin, Ryu Keun Woo, Kim Dae-Seok, Nandu Tulip, Medina Carlos J, Gupte Rebecca, Gibson Bryan A, Soccio Raymond E, Yu Yonghao, Gupta Rana K, Kraus W Lee: PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. Molecular cell 65 (2): 260-271,2017.

Soccio RE: High fat diet induced remodeling of PPARg binding sites in mouse visceral white adipose tissue Keystone Meeting on Nuclear Receptors, Snowbird, Utah : 2016.

Soccio Raymond E, Chen Eric R, Rajapurkar Satyajit R, Safabakhsh Pegah, Marinis Jill M, Dispirito Joanna R, Emmett Matthew J, Briggs Erika R, Fang Bin, Everett Logan J, Lim Hee-Woong, Won Kyoung-Jae, Steger David J, Wu Ying, Civelek Mete, Voight Benjamin F, Lazar Mitchell A: Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo. Cell 162 (1): 33-44,2015.

Zhang Yuxiang, Fang Bin, Emmett Matthew J, Damle Manashree, Sun Zheng, Feng Dan, Armour Sean M, Remsberg Jarrett R, Jager Jennifer, Soccio Raymond E, Steger David J, Lazar Mitchell A: GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock. Science 348 (6242): 1488-92,2015.

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Academic Contact Info

Smilow Center for Translational Research, Rm 12-112
3400 Civic Center Blvd

Philadelphia, PA 19104
Phone: (215) 370-0515
Patient appointments: 800-789-7366 (PENN)