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Raymond Soccio, MD, PHD

Raymond Soccio, MD, PHD Physician

Assistant Professor of Medicine

Dr. Soccio is employed by Penn Medicine.

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Clinical Specialties


  • Diabetes
  • Endocrinology

Programs & Centers:

Board Certification:

  • Endocrinology, Diabetes, & Metabolism, 2010

Clinical Expertise:

  • Addison's Disease
  • Adrenal Gland Disorders
  • Chronic Thyroiditis (Hashimoto's Disease)
  • Congenital Adrenal Hyperplasia
  • Cushing's Disease
  • Diabetes
  • Diabetes Education
  • Endocrine Disorders
  • Goiter
  • Graves' Disease
  • Hyperaldosteronism
  • Hypercalcemia
  • Hyperparathyroidism
  • Hyperthyroidism (Overactive Thyroid)
  • Hypogonadism
  • Hypoparathyroidism
  • Hypopituitarism
  • Hypothyroidism (Underactive Thyroid)
  • Multiple Endocrine Neoplasia
  • Osteoporosis
  • Pituitary Gland Disorders
  • Pituitary Tumors
  • Radioactive Iodine (Radioiodine) Therapy
  • Silent Thyroiditis
  • Thyroid Disorders
  • Thyroid Nodule Biopsy
  • Thyroid Nodules
  • Toxic Nodular Goiter
  • Type 1 Diabetes
  • Type 2 Diabetes
View More

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Weill Medical College of Cornell University
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Diabetes Association, National Department of Defense Congressionally Directed Medical Research Programs(CDMRP), National Philadelphia Endocrine Society, Local The Endocrine Society, International

Hospital Affiliation

Dr. Soccio is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Nuclear Receptors, Genetics of Gene Regulation, Lipid Metabolism

Selected Publications:

Angela H Weller, Kiara Benson, Arya Nakhe, Ioana Soatia, Yachen Shen, Raymond E Soccio: The Role of PPARα in Non-Alcoholic Fatty Liver Disease FASEB meeting "Fundamental Biology and Pathophysiology of the Liver", Scottsdale, AZ : 2018.

Soccio Raymond E, Li Zhenghui, Chen Eric R, Foong Yee Hoon, Benson Kiara K, Dispirito Joanna R, Mullican Shannon E, Emmett Matthew J, Briggs Erika R, Peed Lindsey C, Dzeng Richard K, Medina Carlos J, Jolivert Jennifer F, Kissig Megan, Rajapurkar Satyajit R, Damle Manashree, Lim Hee-Woong, Won Kyoung-Jae, Seale Patrick, Steger David J, Lazar Mitchell A: Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. The Journal of clinical investigation 127 (4): 1451-1462,2017.

Luo Xin, Ryu Keun Woo, Kim Dae-Seok, Nandu Tulip, Medina Carlos J, Gupte Rebecca, Gibson Bryan A, Soccio Raymond E, Yu Yonghao, Gupta Rana K, Kraus W Lee: PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. Molecular cell 65 (2): 260-271,2017.

Soccio RE: High fat diet induced remodeling of PPARg binding sites in mouse visceral white adipose tissue Keystone Meeting on Nuclear Receptors, Snowbird, Utah : 2016.

Soccio Raymond E, Chen Eric R, Rajapurkar Satyajit R, Safabakhsh Pegah, Marinis Jill M, Dispirito Joanna R, Emmett Matthew J, Briggs Erika R, Fang Bin, Everett Logan J, Lim Hee-Woong, Won Kyoung-Jae, Steger David J, Wu Ying, Civelek Mete, Voight Benjamin F, Lazar Mitchell A: Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo. Cell 162 (1): 33-44,2015.

Zhang Yuxiang, Fang Bin, Emmett Matthew J, Damle Manashree, Sun Zheng, Feng Dan, Armour Sean M, Remsberg Jarrett R, Jager Jennifer, Soccio Raymond E, Steger David J, Lazar Mitchell A: GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock. Science 348 (6242): 1488-92,2015.

Soccio Raymond E, Chen Eric R, Lazar Mitchell A: Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. Cell metabolism 20 (4): 573-91,2014.

Tian Lifeng, Wang Chenguang, Hagen Fred K, Gormley Michael, Addya Sankar, Soccio Raymond, Casimiro Mathew C, Zhou Jie, Powell Michael J, Xu Ping, Deng Haiteng, Sauve Anthony A, Pestell Richard G: Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells. Oncotarget 5 (17): 7303-15,2014.

Soccio RE: Chapter 7: The StarD4 subfamily: StarD4 and StarD5 in cholesterol metabolism. Cholesterol Transporters of the START Domain Protein Family in Health and Disease : 2014.

Soccio RE: Allelic Imbalance in PPARγ binding sites and gene expression in human adipocytes 2012 Keystone Meeting on Nuclear Receptors, Whistler, British Columbia : 2012.

View all publications

Academic Contact Info

Smilow Center for Translational Research, Rm 12-112
3400 Civic Center Blvd

Philadelphia, PA 19104
Phone: (215) 370-0515
Patient appointments: 800-789-7366 (PENN)