Description of Research Expertise:
An extension of Dr. Shanti’s clinical interest in functional rehabilitation surgery through the utilization of reconstructive microsurgical techniques has been regenerative medicine. Dr. Shanti is currently investigating the potential of mesenchymal stem cells in tongue tissue engineering, as well as, the engineering of other orofacial tissues. This work is in collaboration with investigators from Penn Dental Medicine and Penn Medicine. Dr. Shanti also has a special interest in rare pathology of the head and neck, in investigating the pathogenesis of benign tumors and cysts of the jaw (i.e., ameloblastoma, odontogenic keratocyst, ossifying fibroma), and rare malignant tumors of the oral cavity (i.e., carcinosarcoma, osteosarcoma). Dr. Shanti has also been involved in investigative studies looking at complex infections of the head and neck (e.g., deep neck infections, osteomyelitis of the jaws) and for this work he was the co-recipient of the Daniel M. Laskin Award for the "most outstanding article published in the Journal of Oral and Maxillofacial Surgery in 2006."
Project title: Stromal cell-derived IL-6 promotes epithelial tumor stem-like cell generation by inducing epithelial-mesenchymal transition in ameloblastoma
Sponsoring Program: Oral & Maxillofacial Surgery Foundation Research Support Grant
Project title: Mesenchymal stromal cell-derived IL-6 facilitate EMT process and acquisition of stem-like cell properties in ameloblastoma epithelial cells
Sponsoring Program: Schoenleber Pilot Grant, School of Dental Medicine, University of Pennsylvania
Pratyusha Yalamanchi, William W Thomas, MD, Alan Workman, Karthik Rajasekaran, MD, Rabie M Shanti, DMD, MD, Ara C Chalian, MD, Jason G Newman, MD, Steven B Cannady, MD: Value of intensive care unit–based management for microvascular free flap reconstruction in head and neck surgery. Annual Meeting of the American Head and Neck Society : 2018.
Shang W, Zhang Q, Huang Y, Shanti R, Alawi F, Le D, Jiang C: Cellular plasticity-targeted therapy in head and neck cancers. Journal of Dental Research : 2018.
Shanti RM,O'Malley BW Jr.: Surgical management of oral cancer. Dental Clinics of North America 62 (2): 77-86,2018.
Mupparapu M,Shanti RM: Evaluation and staging of oral cancer. Dental Clinics of North America 62 (1): 47-58,2018.
Shanti RM, Smart RJ, Meram A, Kim D.: Porcine urinary bladder extracellular matrix for the salvage of fibula free flap skin paddle: technical note and description of a case. Craniomaxillofacial Trauma & Reconstruction 10 (4): 318-22,2017.
Thomas WW, Brant J, Chen J, Coblens O, Fischer JP, Newman JG, Chalian AA, Shanti RM, Cannady SB: Clinical factors associated with reoperation and prolonged length of stay in free tissue transfer to oncologic head and neck defects. JAMA Facial Plastic Surgery : 2017.
Jiang C, Zhang Q, Shanti RM, Shi S, Chang TH, Carrasco L, Alawi F, Le AD: Mesenchymal stromal cell-derived interleukin-6 promotes epithelial-mesenchymal transition and acquisition of epithelial stem-like cell properties in ameloblastoma epithelial cells. Stem Cells 35 (9): 2083-94,2017.
Gomez ED, Thakkar P, Rajasekaran K, Brody R, Shanti R, Newman JG, Cannady SB: Patient characteristics as predictors of postoperative complications in free flap reconstruction for head and neck cancer.
American Head & Neck Society Annual Meeting : 2017.
Tanaka TI, Shanti RM: Coordinated care of a pregnant patient with nasopharyngeal carcinoma. American Academy of Oral Medicine Annual Conference : 2017.
Shanti RM, Kim DD, Ghali GE.: Melanoma. Oral and Maxillofacial Surgery: 3 Volume Set, 3rd Edition 2 : 690-706,2017.