Description of Research Expertise:
My expertise is in the clinical development of novel pharmaceutical compounds both large and small molecules.
Since leaving the full-time faculty at the University of Pennsylvania in 2005, I have worked in Cardiovascular early stage drug development (Phase 0-2)and immunology late stage development (Phase 2b-3). From 2005-2007, I worked at Wyeth Research focused on nuclear hormone receptor targets (PPAR, FXR, LXR) in dyslipidemia and diabetes.
From 2007 onward, I have worked on the clinical development of novel monoclonal antibodies targeting IL-12 and/or IL-23 in immune mediated diseases. This work led to the global approval of ustekinumab (Stelara) in 65+ countries for moderate to severe psoriasis. Currently I am focused on developing ustekinumab in psoriatic arthrtitis as well as overseeing a a Phase 3 program in Crohn's Disease and a proof of concept study in Rheumatoid Arthritis. This body of work led to Stelara being awarded the 2012 International Prix Galien Award for Best Product.
Bloedon L and Szapary P: Flaxseed: A functional food for cardiovascular risk reduction Nutr Rev 62 : 18-27,2004.
Foster G, Wyatt HR, Hill JO, McGuckin G, Brill C, Mohammed SB, Szapary PO, Rader DJ, Edman JS, Klein SK: A multi-center, randomized, controlled clinical trial of the Atkin's diet NEJM 348 : 2082-2090,2003.
Szapary P, Wolfe ME, Bloedon L, Cucchiara A, DerMarderosian A, Cirigliano M, Rader DJ: Guggulipid for the treatment of hypercholesterolemia: A randomized, controlled trial JAMA 290 : 765-772,2003.
Szapary P, Wolfe ME, Cucciara A, Reilly MP, Rader DJ: Metabolic effects of Guggulipid: Results from a randomized controlled factor FACT 8 : 542,2003.
Szapary P: Complementary and alternative medicine therapies in the management of lipid disorders: A review of current evidence Textbook of Complementary and Alternative Medicine : 245-257,2003.
Guerra C and Szapary P: The definition of myocardial infarction [Letter to the Editor] Arch Int Med 163 : 245,2003.
Basch E, Ulbricht C, Kuo G, Szapary P, Smith M: Therapeutic applications of Fenugreek Alternative Medicine Review 8 : 20-27,2003.
Szapary P: Can a perioperative nutritional drink help patients before heart bypass surgery Focus on Alternative and Complementary Therapies (FACT) 8 : 35-36,2003.
Szapary P and DerMarderosian A: Herbal medicine and drug-herb interactions case Medical Nutrition and Disease 3rd edition : 90-95,2003.
Basch E, Ulbricht C, Harrison M, Sollars D, Smith M, Dennehy C, Szapary P: Alfalfa (Medicago sativa L): A clinical decision support tool J Herbal Pharmacother 3 : 69-90,2003.