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Adults (18-65), Geriatrics (65+)
English and Spanish
Adults (18-65), Geriatrics (65+)
English and Spanish
Recognized by Best Doctors in America 2015 - 2018
330 South 9th Street
Philadelphia, PA 19107
A facility of Pennsylvania Hospital
Penn Neuroscience Center, Perelman Center for Advanced Medicine
South Pavilion, 2nd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
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Responses are measured on a scale of 1 to 5 with 5 being the best score.
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Dr. Gonzalez-Alegre is a highly committed clinician-scientist who directs a laboratory devoted to the investigation of the neurobiological bases and therapeutics of dystonia. For his research efforts, funded through federal and private sources, he has been recognized with 2003 S Weir Mitchell Award of the American Academy of Neurology, the 2004 Junior Award for Excellence in Basic Science Research from the Movement Disorders Society, the 2012 Jon Stolk Award in Movement Disorders from the American Academy of Neurology, and the 2012 Stanley Fahn Award from the Dystonia Medical Research Foundation. He is also Co-Director for Clinical Programs of the Raymond G. Perelman Center for Cellular & Molecular Therapy at the Children Hospital of Philadelphia, involved in translational efforts to advance novel molecular therapies for various neurological diseases to early phase clinical trials.
Zech M, Jech R, Boesch S, Škorvánek M, Weber S, Wagner M, Zhao C, Jochim A, Necpál J, Dincer Y, Vill K, Distelmaier F, Stoklosa M, Krenn M, Grunwald S, Bock-Bierbaum T, Fečíková A, Havránková P, Roth J, Příhodová I, Adamovičová M, Ulmanová O, Bechyně K, Danhofer P, Veselý B, Haň V, Pavelekova P, Gdovinová Z, Mantel T, Meindl T, Sitzberger A, Schröder S, Blaschek A, Roser T, Bonfert MV, Haberlandt E, Plecko B, Leineweber B, Berweck S, Herberhold T, Langguth B, Švantnerová J, Minár M, Ramos-Rivera GA, Wojcik MH, Pajusalu S, Õunap K, Schatz UA, Pölsler L, Milenkovic I, Laccone F, Pilshofer V, Colombo R, Patzer S, Iuso A, Vera J, Troncoso M, Fang F, Prokisch H, Wilbert F, Eckenweiler M, Graf E, Westphal DS, Riedhammer KM, Brunet T, Alhaddad B, Berutti R, Strom TM, Hecht M, Baumann M, Wolf M, Telegrafi A, Person RE, Zamora FM, Henderson LB, Weise D, Musacchio T, Volkmann J, Szuto A, Becker J, Cremer K, Sycha T, Zimprich F, Kraus V, Makowski C, Gonzalez-Alegre P, Bardakjian TM, Ozelius LJ, Vetro A, Guerrini R, Maier E, Borggraefe I, Kuster A, Wortmann SB, Hackenberg A, Steinfeld R, Assmann B, Staufner C, Opladen T, Růžička E, Cohn RD, Dyment D, Chung WK, Engels H, Ceballos-Baumann A, Ploski R, Daumke O, Haslinger B, Mall V, Oexle K, Winkelmann J.: Monogenic variants in dystonia: an exome-wide sequencing study. Lancet Neurol 19 (11): 908-918,2020.
Robbins, N. M., Ozmore, J. R., Winder, T. L., Gonzalez-Alegre, P., Bardakjian, T. M.: A Novel SPAST/SPG4 Splice-Site Variant in a Family with Dominant Hereditary Spastic Paraplegia Case Rep Neurol Med 2020 : 7219514,2020.
Zech M, Bardakjian TM, Stoklosa M, Ploski R, Jech R, Gonzalez-Alegre P, Winkelmann J.: A Neurodevelopmental Disorder With Dystonia and Chorea Resulting From Clustering CAMK4 Variants. Mov Disord in press : 2020.
Melis C, Beauvais G, Muntean BS, Cirnaru MD, Otrimski G; Creus-Muncunill J, Martemyanov KA, Gonzalez-Alegre P, Ehrlich ME.: Striatal dopamine induced ERK phosphorylation is altered in mouse models of monogenic dystonia Mov Disord : 2020.
Ogilvie AC, Gonzalez-Alegre P, Schultz JL: Diabetes Mellitus Is Associated With an Earlier Age of Onset of Huntington's Disease Mov Disord : 2020.
Walker IM, Riboldi GM, Drummond P, Saade-Lemus S, Martin-Saavedra JS, Frucht S, Bardakjian TM, Gonzalez-Alegre P, Deik A.: PPP2R5D Genetic Mutations and Early-Onset Parkinsonism. Ann Neurol in press : 2020.
Hamedani A, Bardakjian T, Balcer L, Gonzalez-Alegre P.: Inpatient gastrostomy in Huntington's disease: Nationwide analysis of utilization and outcomes compared to amyotrophic lateral sclerosis Clin Parkinsonism Relat Disord in press : 2020.
Rodriguez Losada N, Wendelbo R; Ocaña Fratan MC; Díaz Casares A; Guzman de Villoria R; Aguirre JA; Arraez MA; Gonzalez-Alegre P; Medina MA; Arenas E; Narvaez-Bueno JA.: Graphene oxide and reduced derivatives, as powder or film scaffolds, differentially promote dopaminergic neuron differentiation and survival Front Neurosci in press : 2020.
Pedro Gonzalez-Alegre; Genevieve Beauvais; Janine Martin; Rick J. Koch; Ruth H. Walker; Jyoti C. Patel; Margaret E. Rice; Michelle E. Ehrlich.: A novel transgenic mouse model to investigate the cell-autonomous effects of torsinA(E) expression in striatal output neurons Neuroscience 422 : 1-11,2019.
Hamedani A, Bardakjian T, Balcer L, Gonzalez-Alegre P.: Contrast acuity and the King-Devick test in Huntington’s Disease. Neuro-Ophthalmology 44 (4): 219-225,2019.
University of PennsylvaniaDepartment of Neurology800 Spruce Street
Patient appointments: 800-789-7366