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Pasquale Santangeli, MD, PhD

Pasquale Santangeli, MD, PhD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Santangeli is employed by Penn Medicine.

In New Jersey, providers are affiliated with Penn Medicine through Clinical Health Care Associates of New Jersey.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiology

Clinical Expertise:

  • Ablation of Idiopathic Ventricular Tachycardia
  • Ablation of Ischemic Ventricular Tachycardia
  • Atrial Fibrillation (Afib)
  • Atrial Fibrillation Treatment
  • Biventricular Device Implantation
  • Biventricular Device Optimization
  • Bradycardia
  • Cardiac Catheter Ablation
  • Complex Arrhythmia
  • Electrocardiogram (EKG or ECG)
  • Electrocardiography (ECG or EKG)
  • Electrophysiology (EP) Testing
  • Epicardial Ablation
  • Heart Palpitations
  • Heart Rhythms - Slow/Fast
  • Implantable Cardioverter Defibrillator
  • Intracardiac Echocardiography (ICE)
  • Intracardiac Ultrasound
  • Pulmonary Vein Antrum Isolation (PVAI)
  • Radiofrequency Ablation (RFA)
  • Supraventricular Tachycardia (SVT)
  • Syncope (Fainting)
  • Tachycardia
  • Ventricular Tachycardia
  • Ventricular Tachycardia Ablation
  • Wolff-Parkinson-White Syndrome

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Vetrans Choice Program (6/2018 Not Active)

Education and Training

Medical School: University of Rome
Fellowship: Catholic University of the Sacred Heart
Fellowship: Stanford University Medical Center


Heart Rhythm Society, National

Hospital Affiliation

Dr. Santangeli is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Selected Publications:

Muser D, Santangeli P, Castro SA, Liang JJ, Enriquez A, Werner TJ, Nucifora G, Magnani S, Hayashi T, Zado ES, Garcia FC, Callans DJ, Dixit S, Desjardins B, Marchlinski FE, Alavi A.: Prognostic role of serial quantitative evaluation of 18F-fluorodeoxyglucose uptake by PET/CT in patients with cardiac sarcoidosis presenting with ventricular tachycardia. Eur J Nucl Med Mol Imaging 45 (8): 1394-1404,2018.

Santangeli P, Zado ES, Garcia FC, Riley MP, Lin D, Frankel DS, Supple GE, Schaller RD, Dixit S, Callans DJ, Marchlinski FE: Lack of Prognostic Value of Atrial Arrhythmia Inducibility and Change in Inducibility Status Following Catheter Ablation of Atrial Fibrillation. Heart Rhythm 15 (5): 660-65,2018.

Muser Daniel, Santangeli Pasquale, Liang Jackson J, Castro Simon A, Magnani Silvia, Hayashi Tatsuya, Garcia Fermin C, Frankel David, Dixit Sanjay, Zado Erica S, Lin David, Desjardins Benoit, Callans David J, Alavi Abass, Marchlinski Francis E: Characterization of the Electroanatomic Substrate in Cardiac Sarcoidosis: Correlation With Imaging Findings of Scar and Inflammation. JACC: Clinical Electrophysiology 4 (3): 291-303,2018.

Enriquez A, Liang J, Gentile J, Schaller RD, Supple GE, Frankel DS, Garcia FC, Wald J, Birati EY, Rame JE, Bermudez C, Callans DJ, Marchlinski FE, Santangeli P.: Outcomes of rescue cardiopulmonary support for periprocedural acute hemodynamic decompensation in patients undergoing catheter ablation of electrical storm. Heart Rhythm 15 (1): 75-80,2018.

Sadek MM, Cooper JM, Frankel DS, Santangeli P, Epstein AE, Marchlinski FE, Schaller RD.: Utility of intracardiac echocardiography during transvenous lead extraction. Heart Rhythm 14 (12): 1779-85,2017.

Santangeli P, Epstein AE.: Sudden cardiac death: lessons learned from cardiac implantable rhythm devices. Cardiac Electrophysiology Clinics 9 (4): 749-59,2017.

Mohanty S, Mohanty P, Di Biase L, Trivedi C, Morris EH, Gianni C, Santangeli P, Bai R, Sanchez JE, Hranitzky P, Gallinghouse GJ, Al-Ahmad A, Horton RP, Hongo R, Beheiry S, Elayi CS, Lakkireddy D, Madhu Reddy Y, Viles Gonzalez JF, Burkhardt JD, Natale A.: Long-term follow-up of patients with paroxysmal atrial fibrillation and severe left atrial scarring: comparison between pulmonary vein antrum isolation only or pulmonary vein isolation combined with either scar homogenization or trigger ablation. Europace 19 (11): 1790-1797,2017.

Enriquez A, Pathak RK, Santangeli P, Liang JJ, Al Rawahi M, Hayashi T, Muser D, Frankel DS, Supple, G, Schaller R, Lin D, Nazarian S, Zado E, Marchlinski FE, Garcia FC.: Inferior lead discordance in ventricular arrhythmias: A specific marker for certain arrhythmia locations. J Cardiovasc Electrophysiol. 10 : 1179-1186,2017.

Santangeli P, Epstein AE.: Exploring the dark side of left atrial appendage closure devices. J Cardiovasc Electrophysiol. : 2017.

Santangeli P, Dixit S.: Role of entrainment in the era of high-density activation mapping for characterizing the reentrant circuit. Heart Rhythm. 14 (10): 1550-1551,2017.

Academic Contact Info

Hospital of the University of Pennsylvania
Clinical Cardiac Electrophysiology
9 Founders Building
3400 Spruce Street

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)