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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Hospital of the University of Pennsylvania
Medical/Intermediate Intensive Care, 9 Founders
3400 Spruce Street
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
My research interests stem from my clinical interest in sepsis and lung injury. Our lab investigates how red blood cells and lung endothelium modulate innate immune responses. Our current research aims to understand the mechanisms of the programmed cell death pathway necroptosis in lung endothelium and the role of danger signals released during necroptosis in the development of lung injury. We have also focused on defining the immunomodulatory properties of RBCs and their role in the development of lung injury. Our lab utilizes murine models, human cell culture models, patient samples and dynamic microfluidic models of RBC-induced endothelial injury in order to understand how perturbations of normal RBC and endothelial function contribute to lung inflammation and injury.
H. Luke Anderson, Igor E. Brodsky, Nilam S. Mangalmurti: The evolving erythrocyte: RBCs as modulators of innate immunity Journal of Immunology 201 (5): 1343-1351,2018.
Hotz JM, Qing D, Shashaty Michael GS, Zhang P, Faust H, Sondheimer N, Rivella S, Worthen GS, Mangalmurti, NS.: RBCs homeostatically bind mtDNA through TLR9 to maintain quiescence and prevent lung injury American Journal of Respiratory and Critical Care Medicine 197 (4): 470-480, 2018.
Qing D, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.: Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation American Journal of Respiratory and Critical Care Medicine 190 (11): 1243-54,2014.
Faust HE, Mangalmurti NS: Collateral Damage: Necroptosis in the Development of Lung Injury Am J Physiol Lung Cell Mol Physiol
Jeongyun Seo1, David Conegliano1, Megan Farrell, Minseon Cho, Xueting Ding, Thomas Seykora, Danielle Qing, Nilam S. Mangalmurti, Dongeun Huh: A microengineered model of RBC transfusion-induced pulmonary vascular injury Scientific Reports 7 (1): 3413,2017.
Shashaty MGS, Reilly JP, Sims C, Holena DN, Qing D, Meyer NJ, Lanken PN, Feldman HI, Christie JD, Mangalmurti NS: Plasma levels of receptor interacting protein kinase-3 (RIP3), an essential mediator of necroptosis, are associated with acute kidney injury in critically ill trauma patients. Shock 46 (2): 139-143,2016.
Michael G. S. Shashaty, MD, MSCE; John P. Reilly, M.D., M.S.C.E.; Hilary E. Faust, M.D.; Caitlin M. Forker, B.A.; Caroline A. G. Ittner, Ph.D.; Peggy X. Zhang, B.S.; Meghan J. Hotz, B.S.; David Fitzgerald; Wei Yang, Ph.D.; Brian J. Anderson, M.D., M.S.C.E.; Daniel N. Holena, MD, MSCE; Paul N. Lanken, M.D., M.S.C.E.; Jason D. Christie, M.D., M.S.C.E.; Nuala J. Meyer, MD, MS; Nilam S. Mangalmurti, M.D.: Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study Critical Care 23 (1): 2019.
Faust HE, Reilly JP, Anderson BJ, Ittner CAG, Forker CM, Zhang P, Weaver BA, Holena DN, Lanken PN, Christie JD, Meyer NJ, Mangalmurti NS, Shashaty MGS: Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients. Chest : 2019.
Mangalmurti NS, Friedman JL, Wang LC, Stolz DB, Muthukumaran G, Siegel DL, Schmidt AM, Lee JS, Albelda SM: The Receptor for Advanced Glycation End Products Mediates Lung Endothelial Activation by RBCs Am J Physiol Lung Cell Mol Physiol 304 (4): L250-63,2013.
Mangalmurti Nilam S, Xiong Zeyu, Hulver Mei, Ranganathan Mrunalini, Liu Xiang Hong, Oriss Timothy, Fitzpatrick Meghan, Rubin Marc, Triulzi Darrell, Choi Augustine, Lee Janet S: Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood 113 (5): 1158-66,2009.
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