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Nilam Mangalmurti, MD

Nilam Mangalmurti, MD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Mangalmurti is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Pulmonary Medicine

Programs & Centers:

Board Certification:

  • Critical Care Medicine, 2009
  • Pulmonary Disease, 2008

Clinical Expertise:

  • Acute Respiratory Distress Syndrome (ARDS)
  • Critical Care Medicine
  • Respiratory Failure
  • Respiratory Intensive Care
  • Sepsis (Septicemia)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Temple University School of Medicine
Residency: New York University Medical Center
Fellowship: UPMC Presbyterian

Memberships

American Thoracic Society, International Institute for Translational Medicine and Therapeutics, National Society of Critical Care Medicine, International

Hospital Affiliation

Dr. Mangalmurti is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

My research interests stem from my clinical interest in sepsis and lung injury. Our lab investigates how red blood cells and lung endothelium modulate innate immune responses. Our current research aims to understand the mechanisms of the programmed cell death pathway necroptosis in lung endothelium and the role of danger signals released during necroptosis in the development of lung injury. We have also focused on defining the immunomodulatory properties of RBCs and their role in the development of lung injury. Our lab utilizes murine models, human cell culture models, patient samples and dynamic microfluidic models of RBC-induced endothelial injury in order to understand how perturbations of normal RBC and endothelial function contribute to lung inflammation and injury.

Selected Publications:

H. Luke Anderson, Igor E. Brodsky, Nilam S. Mangalmurti: The evolving erythrocyte: RBCs as modulators of innate immunity Journal of Immunology 201 (5): 1343-1351,2018.

Hotz JM, Qing D, Shashaty Michael GS, Zhang P, Faust H, Sondheimer N, Rivella S, Worthen GS, Mangalmurti, NS.: RBCs homeostatically bind mtDNA through TLR9 to maintain quiescence and prevent lung injury American Journal of Respiratory and Critical Care Medicine 197 (4): 470-480, 2018.

Qing D, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.: Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation American Journal of Respiratory and Critical Care Medicine 190 (11): 1243-54,2014.

Jeongyun Seo1, David Conegliano1, Megan Farrell, Minseon Cho, Xueting Ding, Thomas Seykora, Danielle Qing, Nilam S. Mangalmurti, Dongeun Huh: A microengineered model of RBC transfusion-induced pulmonary vascular injury Scientific Reports 7 (1): 3413,2017.

Shashaty MGS, Reilly JP, Sims C, Holena DN, Qing D, Meyer NJ, Lanken PN, Feldman HI, Christie JD, Mangalmurti NS: Plasma levels of receptor interacting protein kinase-3 (RIP3), an essential mediator of necroptosis, are associated with acute kidney injury in critically ill trauma patients. Shock 46 (2): 139-143,2016.

Mangalmurti NS, Friedman JL, Wang LC, Stolz DB, Muthukumaran G, Siegel DL, Schmidt AM, Lee JS, Albelda SM: The Receptor for Advanced Glycation End Products Mediates Lung Endothelial Activation by RBCs Am J Physiol Lung Cell Mol Physiol 304 (4): L250-63,2013.

Mangalmurti Nilam S, Chatterjee Shampa, Cheng Guanjun, Andersen Emily, Mohammed Aishat, Siegel Donald L, Schmidt Ann Marie, Albelda Steven M, Lee Janet S: Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products. Transfusion 50 (11): 2353-61,2010.

Mangalmurti Nilam S, Xiong Zeyu, Hulver Mei, Ranganathan Mrunalini, Liu Xiang Hong, Oriss Timothy, Fitzpatrick Meghan, Rubin Marc, Triulzi Darrell, Choi Augustine, Lee Janet S: Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood 113 (5): 1158-66,2009.

Christie JD, Shah CV, Kawut SM, Mangalmurti N, Lederer DJ, Sonett JR, , Ahya VN, Palmer SM, Wille K, Lama V, Shah PD, Shah A, Weinacker A, , Deutschman CS, Kohl BA, Demissie E, Bellamy S, Ware LB: Plasma Levels of Receptor for Advanced Glycation End-Products (sRAGE), Blood Transfusion, and Risk Of Primary Graft Dysfunction American Journal of Respiratory and Critical Care Medicine 180 (10): 1010-1015,2009.

Yani Zhao, Nilam Mangalmurti, Zeyu Xiong, Bharat Prakash, Fengli Guo, Donna B. Stolz, and Janet S. Lee: Duffy antigen receptor chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells. Plos One 6 (12): e29624,2011.

Academic Contact Info

Stemmler Hall
3450 Hamilton Walk

Philadelphia, PA 19104
Phone: (215) 573-9918