Description of Research Expertise:
Dr. Sims has a strong interest in chronic obstructive pulmonary disease (COPD), with a focus on mechanisms of lung inflammation and disease progression. He has been the principal investigator of a K23 award from the NIH/NHLBI investigating surfactant protein D as a modulator of lung inflammation and COPD pathogenesis. He has completed a Masters Degree in Clinical Epidemiology at the University of Pennsylvania, and his Master’s Thesis focused on functional consequences of secondary pulmonary hypertension in patients with severe COPD. In addition, he has been actively involved in multiple clinical and translational studies of biomarkers and novel therapies for COPD and asthma as well as bronchoscopic treatments for severe emphysema.
Atochina-Vasserman EN, Guo C-J, Abramova E, Golden TN, Sims MW, James ML, Beers MF, Gow AJ, Krymskaya VP: Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis American Journal of Respiratory Cell and Molecular Biology 53 (1): 96-104,2015.
Sims MW: Acute respiratory failure due to chronic obstructive pulmonary disease The Intensive Care Unit Manual, 2nd Edition : 715-22,2014.
Lipson DA, Holsclaw D, Imbesi G, Ferrin M, Sims MW, Miller S, Tal-Singer R, Hadjiliadis D: Evidence of Elevated CXCR2 Agonists in Stable Outpatients with Cystic Fibrosis Compared with Healthy Controls Journal of Pulmonary and Respiratory Medicine 3 (3): 149,2013.
Sims MW: Bullous lung disease Clinical Decision Support in Medicine - Epub : 2013.
Sims MW: Aerosol therapy for obstructive lung diseases: device selection and practice management issues Chest 140 (3): 781–788,2011.
Sims MW, Panettieri RA: Profile of aclidinium bromide in the treatment of chronic obstructive pulmonary disease International Journal of COPD 6 (1): 457-66,2011.
Sims MW, Beers MF, Ahya VN, Kawut SM, Sims KD, Lederer DJ, Palmer SM, Wille K, Lama V, Shah PD, Orens JB, Bhorade S, Crespo M, Weinacker A, Demissie E, Bellamy S, Christie JD, and Ware LB for the Lung Transplant Outcomes Group: Effect of Single versus Bilateral Lung Transplantation on Plasma Surfactant Protein D Levels in Idiopathic Pulmonary Fibrosis Chest 140 (2): 489-96,2011.
Amrani Y, Syed F, Huang C, Li K, Liu V, Jain D, Keslacy S, Sims MW, Baidouri H, Cooper PR, Zhao H, Siddiqui S, Brightling CE, Griswold D, Li L, Panettieri RA: Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13 Respiratory Research 11 : 104,2010.
Sims MW, Beers MF, Ahya VN, Kawut SM, Sims KD, Lederer DJ, Palmer SM, Wille K, Lama V, Shah PD, Orens JB Bhorade S, Crespo M, Weinacker A, Demissie E, Bellamy S, Christie JD, and Ware LB for the Lung Transplant Outcomes Group: Effect of Single versus Bilateral Lung Transplantation on Plasma Surfactant Protein D Levels in Idiopathic Pulmonary Fibrosis Abstract selected for poster discussion at 2010 ATS Conference : 2010.
Sims MW, Musani AI, Sareli C, Russell W, McLaren WJ, Delaney PM, Litzky LA, Panettieri RA: A Pilot Study of the Feasibility of Confocal Endomicroscopy
for Examination of the Human Airway J Bronchol Intervent Pulmonol 17 (2): 126-30,2010.