Description of Research Expertise:
Dr. Shashaty's career is focused on epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI), in critical illness populations.
Dr. Shashaty’s studies are mostly focused on critically ill trauma, sepsis, and lung transplant patients. He is the principal investigator of Penn’s cohort study of acute organ dysfunction after trauma. In this population he has studied clinical, molecular, and genetic risk factors for AKI. Current studies include 1) adipokines and inflammatory mediators as mechanisms underlying the association of obesity and AKI, the subject of his K23 Mentored Career Development Award and 2) programmed necrosis as a mechanism of cell death in AKI, supported by a McCabe Fund Pilot Award and a pilot award from the Penn Acute Research Collaboration.
Dr. Shashaty is also the principal investigator of the Lung Transplant Outcomes Group - Acute Kidney Injury (LTOG-AKI) study, a multicenter R01-funded study of the clinical epidemiology of AKI, molecular markers of AKI, and AKI prediction after lung transplantation. Pilot studies in this population were previously supported by a Penn University Research Foundation Award, and LTOG-AKI utilizes the infrastructure of the R01-funded Lung Transplant Outcomes Group (Dr. Jason Christie, PI) which was created in 2002 to study the epidemiology of primary graft dysfunction.
Dr. Shashaty collaborates in multiple other research efforts at Penn. In trauma, he is a co-investigator for a Department of Defense Grant (Dr. Nilam Mangalmurti, PI) to study molecular markers of necroptosis as mediators of transfusion-associated acute respiratory distress syndrome. He also works with Dr. Nuala Meyer to manage the division’s Molecular Epidemiology of Severe Sepsis in the ICU (MESSI) cohort, in which he spearheads both epidemiologic and molecular studies of AKI risk. He partners with other critical care researchers on studies of ARDS, delirium and cognitive dysfunction, and frailty in both sepsis and trauma populations. He also collaborates with translational and epidemiologic investigators in the Renal, Electrolyte, and Hypertension Division to study mechanisms, early identification, and outcomes of AKI.
Forker Caitlin M, Miano Todd A, Reilly John P, Oyster Michelle L, Porteous Mary K, Cantu Edward E, Ware Lorraine B, Diamond Joshua M, Christie Jason D, Shashaty Michael G S: Post-reperfusion plasma endothelial activation markers are associated with acute kidney injury after lung transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons : 2019.
Reilly John P, Zhao Zhiguo, Shashaty Michael G S, Koyama Tatsuki, Christie Jason D, Lanken Paul N, Wang Chunxue, Balmes John R, Matthay Michael A, Calfee Carolyn S, Ware Lorraine B: Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma. American journal of respiratory and critical care medicine 199 (1): 62-70,2019.
Reilly John P, Wang Fan, Jones Tiffanie K, Palakshappa Jessica A, Anderson Brian J, Shashaty Michael G S, Dunn Thomas G, Johansson Erik D, Riley Thomas R, Lim Brian, Abbott Jason, Ittner Caroline A G, Cantu Edward, Lin Xihong, Mikacenic Carmen, Wurfel Mark M, Christiani David C, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Feng Rui, Meyer Nuala J: Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine 44 (11): 1849-1858,2018.
Palakshappa Jessica A, Reilly John P, Schweickert William D, Anderson Brian J, Khoury Viviane, Shashaty Michael G, Fitzgerald David, Forker Caitlin, Butler Kelly, Ittner Caroline A, Feng Rui, Files D Clark, Bonk Michael P, Christie Jason D, Meyer Nuala J: Quantitative peripheral muscle ultrasound in sepsis: Muscle area superior to thickness. Journal of Critical Care 47 : 324-330,2018.
Hotz Meghan J, Qing Danielle, Shashaty Michael G S, Zhang Peggy, Faust Hilary, Sondheimer Neal, Rivella Stefano, Worthen G Scott, Mangalmurti Nilam S: Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury. American journal of respiratory and critical care medicine 197 (4): 470-480,2018.
Meyer Nuala J, Reilly John P, Anderson Brian J, Palakshappa Jessica A, Jones Tiffanie K, Dunn Thomas G, Shashaty Michael G S, Feng Rui, Christie Jason D, Opal Steven M: Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration. Critical care medicine 46 (1): 21-28,2018.
Anderson Brian J, Reilly John P, Shashaty Michael G S, Palakshappa Jessica A, Wysoczanski Alex, Dunn Thomas G, Kazi Altaf, Tommasini Anna, Mikkelsen Mark E, Schweickert William D, Kolson Dennis L, Christie Jason D, Meyer Nuala J: Admission plasma levels of the neuronal injury marker neuron-specific enolase are associated with mortality and delirium in sepsis. Journal of critical care 36 : 18-23,2016.
Shashaty Michael G S, Reilly John P, Sims Carrie A, Holena Daniel N, Qing Danielle, Forker Caitlin M, Hotz Meghan J, Meyer Nuala J, Lanken Paul N, Feldman Harold I, Christie Jason D, Mangalmurti Nilam S: Plasma Levels of Receptor Interacting Protein Kinase-3 (RIP3), an Essential Mediator of Necroptosis, are Associated with Acute Kidney Injury in Critically Ill Trauma Patients. Shock (Augusta, Ga.) 46 (2): 139-43,2016.
Reilly John P, Anderson Brian J, Hudock Kristin M, Dunn Thomas G, Kazi Altaf, Tommasini Anna, Charles Dudley, Shashaty Michael G S, Mikkelsen Mark E, Christie Jason D, Meyer Nuala J: Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis. Critical care (London, England) 20 (1): 222,2016.
Palakshappa Jessica A, Anderson Brian J, Reilly John P, Shashaty Michael G S, Ueno Ryo, Wu Qufei, Ittner Caroline A G, Tommasini Anna, Dunn Thomas G, Charles Dudley, Kazi Altaf, Christie Jason D, Meyer Nuala J: Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis. Critical care (London, England) 20 (1): 71,2016.
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