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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Hospital of the University of Pennsylvania
Medical/Intermediate Intensive Care, 9 Founders
3400 Spruce Street
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
Dr. Shashaty's career is focused on epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI), in critical illness populations.Dr. Shashaty’s studies are mostly focused on critically ill trauma, sepsis, and lung transplant patients. He is the principal investigator of Penn’s cohort study of acute organ dysfunction after trauma. In this population he has studied clinical, molecular, and genetic risk factors for AKI. Current studies include 1) adipokines and inflammatory mediators as mechanisms underlying the association of obesity and AKI, the subject of his K23 Mentored Career Development Award and 2) programmed necrosis as a mechanism of cell death in AKI, supported by a McCabe Fund Pilot Award and a pilot award from the Penn Acute Research Collaboration.Dr. Shashaty is also the principal investigator of the Lung Transplant Outcomes Group - Acute Kidney Injury (LTOG-AKI) study, a multicenter R01-funded study of the clinical epidemiology of AKI, molecular markers of AKI, and AKI prediction after lung transplantation. Pilot studies in this population were previously supported by a Penn University Research Foundation Award, and LTOG-AKI utilizes the infrastructure of the R01-funded Lung Transplant Outcomes Group (Dr. Jason Christie, PI) which was created in 2002 to study the epidemiology of primary graft dysfunction. Dr. Shashaty collaborates in multiple other research efforts at Penn. In trauma, he is a co-investigator for a Department of Defense Grant (Dr. Nilam Mangalmurti, PI) to study molecular markers of necroptosis as mediators of transfusion-associated acute respiratory distress syndrome. He also works with Dr. Nuala Meyer to manage the division’s Molecular Epidemiology of Severe Sepsis in the ICU (MESSI) cohort, in which he spearheads both epidemiologic and molecular studies of AKI risk. He partners with other critical care researchers on studies of ARDS, delirium and cognitive dysfunction, and frailty in both sepsis and trauma populations. He also collaborates with translational and epidemiologic investigators in the Renal, Electrolyte, and Hypertension Division to study mechanisms, early identification, and outcomes of AKI.
Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff ED, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell JA, Christiani DC, Wurfel MM, Lanken PN, Reilly MP, Christie JD: The ABO Histo-Blood Group, endothelial activation, and acute respiratory distress syndrome risk in critical illness J Clin Invest : 2020.
Miano TA, Shashaty M, Yang W, Brown JR, Zuppa A, Hennessy S: Effect of renin-angiotensin system inhibitors on the comparative nephrotoxicity of NSAIDs and opioids during hospitalization Kidney360 1 (7): 604-613,2020.
Miano, T. A., Yang, W., Shashaty, M. G. S., Zuppa, A., Brown, J. R., Hennessy, S.: The Magnitude of the Warfarin-Amiodarone Drug-Drug Interaction Varies With Renal Function: A Propensity-Matched Cohort Study Clin Pharmacol Ther 107 (6): 1446-1456,2020.
Vasquez, C. R., DiSanto, T., Reilly, J. P., Forker, C. M., Holena, D. N., Wu, Q., Lanken, P. N., Christie, J. D., Shashaty, M. G. S.: Relationship of body mass index, serum creatine kinase, and acute kidney injury after severe trauma J Trauma Acute Care Surg : 2020.
Hatchimonji, J. S., Kaufman, E. J., Vasquez, C. R., Shashaty, M. G. S., Martin, N. D., Holena, D. N.: Obesity is Associated With Mortality and Complications After Trauma: A State-Wide Cohort Study J Surg Res 247 : 14-20,2020.
Miano Todd A, Flesch Judd D, Feng Rui, Forker Caitlin M, Brown Melanie, Oyster Michelle, Kalman Laurel, Rushefski Melanie, Cantu Edward, Porteus Mary, Yang Wei, Russel Localio Jd A, Diamond Joshua M, Christie Jason D, Shashaty Michael G S: Early Tacrolimus Concentrations After Lung Transplant are Predicted by Combined Clinical and Genetic Factors and Associated with Acute Kidney Injury. Clinical pharmacology and therapeutics 107 (2): 462-470,2020.
Faust Hilary E, Reilly John P, Anderson Brian J, Ittner Caroline A G, Forker Caitlyn M, Zhang Peggy, Weaver Benjamin A, Holena Daniel N, Lanken Paul N, Christie Jason D, Meyer Nuala J, Mangalmurti Nilam S, Shashaty Michael G S: Plasma Mitochondrial DNA Levels are Associated with Acute Respiratory Distress Syndrome in Trauma and Sepsis Patients. Chest 157 (1): 67-76,2020.
Jones Tiffanie K, Feng Rui, Kerchberger V Eric, Reilly John P, Anderson Brian J, Shashaty Michael G S, Wang Fan, Dunn Thomas G, Riley Thomas R, Abbott Jason, Ittner Caroline A G, Christiani David C, Mikacenic Carmen, Wurfel Mark M, Ware Lorraine B, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Meyer Nuala J: Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. American journal of respiratory and critical care medicine 201 (1): 47-56,2020.
Anderson, B. J., Calfee, C. S., Liu, K. D., Reilly, J. P., Kangelaris, K. N., Shashaty, M. G. S., Lazaar, A. L., Bayliffe, A. I., Gallop, R. J., Miano, T. A., Dunn, T. G., Johansson, E., Abbott, J., Jauregui, A., Deiss, T., Vessel, K., Belzer, A., Zhuo, H., Matthay, M. A., Meyer, N. J., Christie, J. D.: Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study Crit Care 23 (1): 400,2019.
Shashaty Michael G S, Forker Caitlin M, Miano Todd A, Wu Qufei, Yang Wei, Oyster Michelle L, Porteous Mary K, Cantu Edward E, Diamond Joshua M, Christie Jason D: The association of post-lung transplant acute kidney injury with mortality is independent of primary graft dysfunction: A cohort study. Clinical transplantation 33 (10): e13678,2019.
5039 W GatesHospital of the University of Pennsylvania3400 Spruce Street