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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Hospital of the University of Pennsylvania
Medical/Intermediate Intensive Care, 9 Founders
3400 Spruce Street
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
Dr. Shashaty's career is focused on epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI), in critical illness and populations.Dr. Shashaty has formal training in the clinical practice of pulmonary and critical care medicine, biostatistical and epidemiologic methods, and protein, gene expression, and genomic analyses of human biospecimens. He is the principal investigator for the Lung Transplant Outcomes Group–Acute Kidney Injury (LTOG-AKI) study, a multicenter prospective cohort of lung transplant recipients (n>1800) designed to study the clinical and molecular epidemiology of post-lung transplant AKI. The primary focus of this study is to determine clinical characteristics and novel blood and urine biomarkers that are useful for AKI prediction and may provide insight into molecular mechanisms of AKI after transplantation. Dr. Shashaty is also the principal investigator for the ongoing Penn Trauma Organ Dysfunction Study (PETROS), a cohort of critically ill trauma patients (n>1300), and a co-investigator in Penn’s Molecular Epidemiology of Severe Sepsis in the ICU (MESSI) cohort, for which he leads studies of AKI. Current areas of study in these cohorts include elucidating mechanisms underlying the association of obesity and AKI, the relevance of programmed cell necrosis in human AKI and ARDS, circulating cell-free DNA as a mechanistic contributor to AKI and ARDS, and genetic risk factors for AKI.
Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Weisman AR, Agyekum R, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ.: Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate with Organ Dysfunction and Mortality in Sepsis Shock : 2021.
Mitchell OJL, Neefe S, Ginestra JC, Baston CM, Frazer MJ, Gudowski S, Min J, Ahmed NH, Pascual JL, Schweickert WD, Anderson BJ, Anesi GL, Falk SA, Shashaty MGS.: Impact of COVID-19 on inpatient clinical emergencies: A single-center experience Resusc Plus 6 : 100135,2021.
Mitchell OJL, Doran O, Yuriditsky E, Root C, Teran F, Ma K, Shashaty M, Moskowitz A, Horowitz J, Abella BS.: Rapid response system adaptations at 40 US hospitals during the COVID-19 pandemic Resusc Plus 6 : 100121,2021.
Vasquez CR, Gupta S, Miano TA, Roche M, Hsu J, Yang W, Holena DN, Reilly JP, Schrauben SJ, Leaf DE, Shashaty MGS for the STOP-COVID Investigators.: Identification of distinct clinical subphenotypes in critically ill patients with COVID-19 Chest : 2021.
Anesi GL, Jablonski J, Harhay MO, Atkins JH, Bajaj J, Baston C, Brennan PJ, Candeloro CL, Catalano LM, Cereda MF, Chandler JM, Christie JD, Collins T, Courtright KR, Fuchs BD, Gordon E, Greenwood JC, Gudowski S, Hanish A, Hanson CW 3rd, Heuer M, Kinniry P, Kornfield ZN, Kruse GB, Lane-Fall M, Martin ND, Mikkelsen ME, Negoianu D, Pascual JL, Patel MB, Pugliese SC, Qasim ZA, Reilly JP, Salmon J, Schweickert WD, Scott MJ, Shashaty MGS, Sicoutris CP, Wang JK, Wang W, Wani AA, Anderson BJ, Gutsche JT.: Characteristics, Outcomes, and Trends of Patients With COVID-19-Related Critical Illness at a Learning Health System in the United States Ann Intern Med 174 : 613-621,2021.
Sjoding MW, Taylor D, Motyka J, Lee E, Co I, Claar D, McSparron JI, Ansari S, Kerlin MP, Reilly JP, Shashaty MGS, Anderson BJ, Jones TK, Drebin HM, Ittner CAG, Meyer NJ, Iwashyna TJ, Ward KR, Gillies CE.: Deep learning to detect acute respiratory distress syndrome on chest radiographs: a retrospective study with external validation Lancet Digit Health : 2021.
Mitchell OJL, Yuriditsky E, Johnson NJ, Doran O, Buckler DG, Neefe S, Seethala RR, Motov S, Moskowitz A, Lee J, Griffin KM, Shashaty MGS, Horowitz JM, Abella BS; Coronavirus 2019 In-Hospital Cardiac Arrest (COVID IHCA) Study Group.: In-hospital cardiac arrest in patients with coronavirus 2019 Resuscitation 160 : 72-78,2021.
Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff E, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell J, Christiani DC, Wurfel MM, Lanken PN, Reilly MP, Christie JD.: The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness J Clin Invest 131 : e139700,2021.
Miano TA, Shashaty M, Yang W, Brown JR, Zuppa A, Hennessy S: Effect of renin-angiotensin system inhibitors on the comparative nephrotoxicity of NSAIDs and opioids during hospitalization Kidney360 1 (7): 604-613,2020.
Miano, T. A., Yang, W., Shashaty, M. G. S., Zuppa, A., Brown, J. R., Hennessy, S.: The Magnitude of the Warfarin-Amiodarone Drug-Drug Interaction Varies With Renal Function: A Propensity-Matched Cohort Study Clin Pharmacol Ther 107 (6): 1446-1456,2020.
5039 W GatesHospital of the University of Pennsylvania3400 Spruce Street