Description of Research Expertise:
Research in my laboratory is focused on T cell biology and applications of genetically-engineered T cells to the treatment of disease. Active research projects in my laboratory include:
1) Developing chimeric antigen receptors (CARs) for adoptive immunotherapy of cancer with enhanced function and improved safety.
2) Developing and applying synthetic immunoreceptors to the treatment of immune-mediated disease.
3) Exploring the role of co-stimulatory signals in directing T cell metabolism and the way this metabolism affects T cell function within tumors.
Ghassemi Saba, Nunez-Cruz Selene, O'Connor Roddy S, Fraietta Joseph A, Patel Prachi R, Scholler John, Barrett David M, Lundh Stefan M, Davis Megan M, Bedoya Felipe, Leferovich John, Lacey Simon F, Levine Bruce L, Grupp Stephan A, June Carl H, Melenhorst J Joseph, Milone Michael C: Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells. Cancer immunology research : In Press,2018.
Milone Michael C, O'Doherty Una: Clinical use of lentiviral vectors. Leukemia 32 (7): 1529-1541,2018.
Laetsch Theodore W, Maude Shannon L, Milone Michael C, Davis Kara L, Krueger Joerg, Cardenas Ana Maria, Eldjerou Lamis K, Keir Christopher H, Wood Patricia A, Grupp Stephan A: False-positive results following lentiviral-based tisagenlecleucel therapy with select HIV-1 NAT methods. Blood 131 (23): 2596-2598,2018.
De-xiu Bu, Reshma Singh, Eugene E. Choi, *, Marco Ruella, Selene Nunez-, Cruz, Keith G. Mansfi eld, Paul Bennett, Nathanial Barton, Qilong Wu, Jiquan, Zhang, Yongqiang Wang, Lai Wei, Shawn Cogan, Tucker Ezell, Shree Joshi, Kellie J. Latimer, Brian Granda, William R. Tschantz, Regina M. Young, Heather, A. Huet, Celeste J. Richardson and Michael C. Milone: Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma Oncotarget 9 (40): 25764-25780,2018.
O'Connor Roddy S, Guo Lili, Ghassemi Saba, Snyder Nathaniel W, Worth Andrew J, Weng Liwei, Kam Yoonseok, Philipson Benjamin, Trefely Sophie, Nunez-Cruz Selene, Blair Ian A, June Carl H, Milone Michael C: The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Scientific reports 8 (1): 6289,2018.
Richman Sarah A, Milone Michael C: Neurotoxicity Associated with a High-Affinity GD2 CAR-Response. Cancer immunology research 6 (4): 496-497,2018.
Garfall Alfred L, Stadtmauer Edward A, Hwang Wei-Ting, Lacey Simon F, Melenhorst Jan Joseph, Krevvata Maria, Carroll Martin P, Matsui William H, Wang Qiuju, Dhodapkar Madhav V, Dhodapkar Kavita, Das Rituparna, Vogl Dan T, Weiss Brendan M, Cohen Adam D, Mangan Patricia A, Ayers Emily C, Nunez-Cruz Selene, Kulikovskaya Irina, Davis Megan M, Lamontagne Anne, Dengel Karen, Kerr Naseem Ds, Young Regina M, Siegel Donald L, Levine Bruce L, Milone Michael C, Maus Marcela V, June Carl H: Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma. JCI insight 3 (8): 2018.
Richman Sarah A, Nunez-Cruz Selene, Moghimi Babak, Li Lucy Z, Gershenson Zachary T, Mourelatos Zissimos, Barrett David M, Grupp Stephan A, Milone Michael C: High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model. Cancer immunology research 6 (1): 36-46,2018.
Michael C. Milone and Bruce L. Levine: Powered and controlled T-cell production Nature Biomedical Engineering 2 : 148-150,2018.
Vijay Bhoj and Michael C. Milone: The pharmacology of T cell therapies Molecular Therapy - Methods & Clinical Development 8 : 210-221,2018.
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