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The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.
Mishra OP, Popov AV, Pietrofesa RA, Hwang WT, Andrake M, Nakamaru-Ogiso E, Christofidou-Solomidou M: Radiation activates myeloperoxidase (MPO) to generate active chlorine species (ACS) via a dephosphorylation mechanism - inhibitory effect of LGM2605. Biochim Biophys Acta Gen Subj. : 2020.
Cameron H. Flayer, Erik D. Larson, Anjali Joseph, Sean Kao, Wenxiu Qu, Austin Van Haren, Christopher M. Royer, Thais Sielecki, Melpo Christofidou-Solomidou, Angela Haczku: Protective effect of LGM2605 on ozone-induced inflammation and hyperreactivity in rhesus macaques J Allergy Clin Immunol 145 (1): 312-323,2020.
Jacovides CL, Ahmed S, Suto Y, Paris AJ, Leone R, Weber M, Johnson VE, Christofidou-Solomidou M, Kaplan LJ, Smith DH, Holena DN, Schwab CW, Pascual JL: An inflammatory pulmonary insult post-traumatic brain injury worsens subsequent spatial learning and neurological outcomes. J. Trauma Acute Care Surg 87 (3): 552-558,2019.
Christofidou-Solomidou M, Pietrofesa R, Park K, Albelda SM, Serve K, Keil D, and Pfau J: Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Libby Amphibole Fiber-Induced Acute Inflammation in Mice Toxicology and Applied Pharmacology 375 : 81-93,2019.
Shampa Chatterjee, Ralph A. Pietrofesa, Kyewon Park, Jian-Qin Tao, Alejandro Carabe-Fernandez, Abigail T. Berman, Constantinos Koumenis, Thais Sielecki, and Melpo Christofidou-Solomidou: LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks International Journal of Molecular Sciences 20 (176): 1-27,2019.
Dimitra Kokkinaki, Matthew Hoffman, Charikleia Kalliora, Anastasios Lymperopoulos, Anna Maria Lucchese, Sanantham Shanmughapriya, Ioannis Kyriazis, Dhanendra Tomar, Joon Young Park, Hong Wang, Xiao-Feng Yang, Muniswamy Madesh, Walter J. Koch, Melpo Christofidou-Solomidou and Konstantinos Drosatos: Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy Journal of Molecular and Cellular Cardiology 127 : 232-245,2019.
Ralph A. Pietrofesa, Shampa Chatterjee, Sandra Pastorino, Haining Yang, Steven M. Albelda, and Christofidou-Solomidou M: The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells International Journal of Molecular Sciences : 2019.
Vladimir V. Shuvaev, Makan Khoshnejad, Katherine W. Pulsipher, Raisa Yu. Kiseleva, Evguenia Arguiri, Jasmina C. Cheung-Lau, Kathleen M. LeFort, Christofidou-Solomidou M, Radu V. Stan, Ivan J. Dmochowski, and Vladimir R. Muzykantov: Spatially controlled assembly of affinity ligand and enzyme cargo enables targeting ferritin nanocarriers to caveolae Biomaterials 185 : 348-359,2018.
Zhou Bing, Yoshi Suzuki, Thomas Disanto, Samantha Rubin, Zachary Penfil, Melpo Christofidou-Solomidou, Edward Cantu: Application of Out of Body Lung Perfusion: Yesterday, Today and Tomorrow Academic Radiology 26 (3): 404-411,2018.
Pietrofesa RA, Chatterjee S, Park K, Arguiri E4, Albelda SM, Christofidou-Solomidou M.: Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner Antioxidants (Basel) 7 (3): 2018.
University of Pennsylvania, Department of MedicinePulmonary, Allergy and Critical Care Division3450 Hamilton Walk,Edward J. Stemmler Hall, Office Suite 227