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Mehran Makvandi, PharmD, RPh, BCNP

Mehran Makvandi, PharmD, RPh, BCNP Researcher

Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

Dr. Makvandi is employed by Penn Medicine.

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American Chemical Society, National American Pharmacists Association , National American Pharmacists Association, National Association for Cancer Research , National Association for Cancer Research, National Kappa Psi Pharmaceutical Fraternity Inc. , National Kappa Psi Pharmaceutical Fraternity Inc., National Society of Nuclear Medicine and Molecular Imaging , National Society of Nuclear Medicine and Molecular Imaging, National

Hospital Affiliation

Dr. Makvandi is employed by Penn Medicine.


Selected Publications:

Reilly SW, Puentes LN, Wilson K, Hsieh CJ, Weng CC, Makvandi M, Mach RH.: Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity. J Med Chem : 2018 .

Sean W. Reilly, Laura N. Puentes, Chia-Ju Hsieh, Mehran Makvandi, and Robert H. Mach: Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions ACS Omega 3 : 9997/10001,2018.

Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL.: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest. : 2018.

Makvandi M, Dupis E, Engle JW, Nortier FM, Fassbender ME, Simon S, Birnbaum ER, Atcher RW, John KD, Rixe O, Norenberg JP.: Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations. Target Oncol. : 2018.

Reilly SW, Makvandi M, Xu K, Mach RH.: Rapid Cu-Catalyzed [211At]Astatination and [125I]Iodination of Boronic Esters at Room Temperature. Org Lett : 2018.

Makvandi M, Sellmyer MA, Mach RH.: Inflammation and DNA damage: Probing pathways to cancer and neurodegeneration. Drug Discov Today Technol : 2017.

Batra V, Makvandi M, Zuppa AF, Patel N, Elias J, Pryma DA, Maris JM.: Dexmedetomidine does not interfere with meta-iodobenzylguanidine (MIBG) uptake at clinically relevant concentrations. Pediatr Blood Cancer 64 (4): e26268,2017.

McDonald ES, Mankoff J, Makvandi M, Chu W, Chu Y, Mach RH, Zeng C.: Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells. Biochem Biophys Res Commun : 2017.

George E, Kim H, Krepler C, Wenz B, Makvandi M, Tanyi JL, Brown E, Zhang R, Brafford P, Jean S, Mach RH, Lu Y, Mills GB, Herlyn M, Morgan M, Zhang X, Soslow R, Drapkin R, Johnson N, Zheng Y, Cotsarelis G, Nathanson KL, Simpkins F.: A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers. JCI Insight : 2017.

Sander Effron S, Makvandi M, Lin L, Xu K, Li S, Lee H, Hou C, Pryma DA, Koch C, Mach RH.: PARP-1 Expression Quantified by [18F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy. Cancer Biother Radiopharm : 2017.

Academic Contact Info

Perelman School of Medicine
University of Pennsylvania
Department of Radiology
Nuclear Medicine and Clinical Molecular Imaging
231 S. 34th Street

Philadelphia, PA 19104
Phone: (215) 746-8755