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Mark E. Mikkelsen, MD, MSCE, FCCM

Mark E. Mikkelsen, MD, MSCE, FCCM Physician

Chief, Section of Medical Critical Care Associate Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Mikkelsen is employed by Penn Medicine.

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There is no publicly available rating for this medical professional for one of the following reasons:

  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients in a medical practice setting.
  3. He or she sees patients but has not yet received the minimum 30 patient satisfaction reviews in the past 12 months, ensuring that the rating is statistically reliable and a true reflection of patient satisfaction.

Clinical Specialties


  • Pulmonary Medicine

Programs & Centers:

Board Certification:

  • Critical Care Medicine, 2009
  • Internal Medicine, 2005
  • Pulmonary Disease, 2008

Clinical Expertise:

  • Acute Respiratory Distress Syndrome (ARDS)
  • Critical Care Medicine
  • Sepsis (Septicemia)

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Virginia
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Thoracic Society, International Society of Critical Care Medicine, International The Philip Drinker Society, Local

Hospital Affiliation

Dr. Mikkelsen is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Mikkelsen is the Chief of the Section of Medical Critical Care at Penn. He serves as Co-Chair of the UPHS Critical Care Committee and Medical Director of the Penn Presbyterian Medical Intensive Care Unit. Through these efforts, he supports the growth and development of a phenomenal group of multidisciplinary Penn providers who are collectively driven to educate the next generation of critical care clinicians, to deliver care of the highest quality to the critically ill, and to create and implement innovative science that advances the field of critical care medicine.

Research Program:
Through the lens of the patient and their family, Dr. Mikkelsen conducts patient-oriented research focused on sepsis, acute respiratory distress syndrome, and long-term outcomes in survivors of critical illness. He is passionate in his goal to improve the delivery of care to critically ill patients and to improve the lives of survivors of critical illness by understanding how critical illness impacts one's life and one's health trajectory.

Dr. Mikkelsen encourages colleagues, as well as survivors of critical illness and their loved ones, who are committed to improving the quality of care delivered to critically ill patients to contact him at Together, we can "be the difference."

Selected Publications:

McPeake J, Mikkelsen ME, Quasim T, Hibbert E, Cannon P, Shaw M, Ankori J, Iwashyna TJ, Haines KJ: Return to employment following critical illness and its association with psychosocial outcomes: a systematic review and meta-analysis Ann Am Thor Soc : 2019.

Lee JT, Mikkelsen ME, Qi M, Werner RM: Health care utilization after admissions for sepsis Ann Am Thorac Soc : 2019.

Deb P, Murtaugh CM, Bowles KH, Mikkelsen ME, Khajavi HN, Moore S, Barrón Y, Hollander Feldman P: Does Early Follow-up Improve the Outcomes of Sepsis Survivors Discharged to Home Health Care? Med Care : 2019.

Mikkelsen ME, Anderson BJ, Bellini L, Schweickert WD, Fuchs BD, Prasad Kerlin M: Burnout, and fulfillment, in the profession of critical care medicine Am J Respir Crit Care Med : 2019.

McPeake J, Mikkelsen ME: The evolution of post-intensive care syndrome Crit Care Med 46 (9): 1551-1552,2018.

Gutsche JT, Miano TA, Vernick W, Raiten J, Bermudez C, Vallabjoysula P, Milewski K, Szeto W, Fall ML, Williams ML, Patel P, Mikkelsen ME, Chiu C, Ramakrishna H, Canon J, Augoustides JG: Does a mobile ECLS program reduce mortality for patients transported for ECLS therapy for severe acute respiratory failure? J Cardiothorac Vasc 32 (3): 1137-1141,2018.

Anderson BJ, Mikkelsen ME: A new direction: sleep and neuropsychological impairment after critical illness Ann Am Thorac Soc 15 (1): 114,2018.

Sepsis Alliance and Society of Critical Care Medicine: Life after sepsis Sepsis Alliance, SCCM and YouTube : 2018.

Maley JH, Mikkelsen ME: What happens to critically ill patients after they leave the ICU? Evidence-Based Practice of Critical Care, 3rd Edition : 2018.

Burling S: Words that heal: ICU journals at Penn help patients and staff Philadelphia Inquirer : 2018.

Academic Contact Info

Gates 05042
3400 Spruce Street
Hospital of the University of Pennsylvania

Philadelphia, PA 19104
Phone: (215) 615-5416