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Marina Cuchel, MD, PhD

Marina Cuchel, MD, PhD Physician

Research Associate Professor of Medicine

Dr. Cuchel is employed by Penn Medicine.

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Clinical Specialties

Memberships

American Heart Association, National European Atherosclerosis Society, International International Atherosclerosis Society, International NIH Study Section (AICS), National

Hospital Affiliation

Dr. Cuchel is employed by Penn Medicine.

Research

Description of Research Expertise:

Dr. Cuchel is interested in the study of mechanisms regulating the metabolism of lipid and lipoproteins, using two parallel approaches: animal models and well-defined human monogenic disorders. She is also interested in early phase development of novel therapeutic strategies for the treatment of rare genetic disorders of lipid metabolism and for the enhancement of reverse cholesterol transport.

Selected Publications:

Sturm Amy C, Knowles Joshua W, Gidding Samuel S, Ahmad Zahid S, Ahmed Catherine D, Ballantyne Christie M, Baum Seth J, Bourbon Mafalda, Carrié Alain, Cuchel Marina, de Ferranti Sarah D, Defesche Joep C, Freiberger Tomas, Hershberger Ray E, Hovingh G Kees, Karayan Lala, Kastelein Johannes Jacob Pieter, Kindt Iris, Lane Stacey R, Leigh Sarah E, Linton MacRae F, Mata Pedro, Neal William A, Nordestgaard Børge G, Santos Raul D, Harada-Shiba Mariko, Sijbrands Eric J, Stitziel Nathan O, Yamashita Shizuya: Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel. Journal of the American College of Cardiology 72 (6): 662-680,2018.

Blom Dirk J, Cuchel Marina, Ager Miranda, Phillips Helen: Target achievement and cardiovascular event rates with Lomitapide in homozygous Familial Hypercholesterolaemia. Orphanet journal of rare diseases 13 (1): 96,2018.

Millar John S, Cuchel Marina: Cholesterol metabolism in humans: a review of methods and comparison of results. Current opinion in lipidology 29 (1): 1-9,2017.

Hancock-Cerutti William, Lhomme Marie, Dauteuille Carolane, Lecocq Sora, Chapman M John, Rader Daniel J, Kontush Anatol, Cuchel Marina: Paradoxical coronary artery disease in humans with hyperalphalipoproteinemia is associated with distinct differences in the high-density lipoprotein phosphosphingolipidome. Journal of clinical lipidology 11 (5): 1192-1200.e3,2017.

Khetarpal Sumeet A, Zeng Xuemei, Millar John S, Vitali Cecilia, Somasundara Amritha Varshini Hanasoge, Zanoni Paolo, Landro James A, Barucci Nicole, Zavadoski William J, Sun Zhiyuan, de Haard Hans, Toth Ildikó V, Peloso Gina M, Natarajan Pradeep, Cuchel Marina, Lund-Katz Sissel, Phillips Michael C, Tall Alan R, Kathiresan Sekar, DaSilva-Jardine Paul, Yates Nathan A, Rader Daniel J: A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nature medicine 23 (9): 1086-1094,2017.

Gaudet Daniel, Gipe Daniel A, Pordy Robert, Ahmad Zahid, Cuchel Marina, Shah Prediman K, Chyu Kuang-Yuh, Sasiela William J, Chan Kuo-Chen, Brisson Diane, Khoury Etienne, Banerjee Poulabi, Gusarova Viktoria, Gromada Jesper, Stahl Neil, Yancopoulos George D, Hovingh G Kees: ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia. The New England journal of medicine 377 (3): 296-297,2017.

Blom Dirk J, Averna Maurizio R, Meagher Emma A, du Toit Theron Hendrik, Sirtori Cesare R, Hegele Robert A, Shah Prediman K, Gaudet Daniel, Stefanutti Claudia, Vigna Giovanni B, Larrey Dominique, Bloedon LeAnne T, Foulds Pamela, Rader Daniel J, Cuchel Marina: Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia. Circulation 136 (3): 332-335,2017.

Liu Ying, Conlon Donna M, Bi Xin, Slovik Katherine J, Shi Jianting, Edelstein Hailey I, Millar John S, Javaheri Ali, Cuchel Marina, Pashos Evanthia E, Iqbal Jahangir, Hussain M Mahmood, Hegele Robert A, Yang Wenli, Duncan Stephen A, Rader Daniel J, Morrisey Edward E: Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress. Cell reports 19 (7): 1456-1466,2017.

Bi Xin, Pashos Evanthia E, Cuchel Marina, Lyssenko Nicholas N, Hernandez Mayda, Picataggi Antonino, McParland James, Yang Wenli, Liu Ying, Yan Ruilan, Yu Christopher, DerOhannessian Stephanie L, Phillips Michael C, Morrisey Edward E, Duncan Stephen A, Rader Daniel J: ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion. EBioMedicine 18 : 139-145,2017.

Cuchel Marina, Raper Anna C, Conlon Donna M, Pryma Daniel A, Freifelder Richard H, Poria Rahul, Cromley Debra, Li Xiaoyu, Dunbar Richard L, French Benjamin, Qu Liming, Farver William, Su Ching-Chiang, Lund-Katz Sissel, Baer Amanda, Ruotolo Giacomo, Akerblad Peter, Ryan Carol S, Xiao Lan, Kirchgessner Todd G, Millar John S, Billheimer Jeffrey T, Rader Daniel J: A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans. Journal of lipid research 58 (4): 752-762,2017.

Academic Contact Info

Institute for Translational Medicine and Therapeutics
8039 Maloney Building
3600 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-7188