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Marcia Brose, MD, PhD

Marcia Brose, MD, PhD Physician

Associate Professor of Otorhinolaryngology: Head and Neck Surgery at the Hospital of the University of Pennsylvania Associate Professor of Medicine

Dr. Brose is employed by Penn Medicine.

About Dr. Marcia Brose

Recognized by Best Doctors in America 2011-2012

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties

Specialty:

  • Medical Oncology
  • Otorhinolaryngology

Programs & Centers:

Board Certification:

  • Medical Oncology, 2003

Clinical Expertise:

  • Thyroid Cancer

Description of Clinical Expertise

Treatment of Thyroid Cancer, PhaseI/II/III clinical trials, novel drug target discovery, and use of genetic testing in diagnosis, prognostication and prediction of resopnse to the treatment of cancer. Treatment of Rare Cancers of the Head and Neck.

Practice Locations and Appointments

  • Abramson Cancer Center

    Perelman Center for Advanced Medicine West Pavilion, 2nd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Weill Medical College of Cornell University
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Academy of Otolaryngology-Head and Neck Surgery, National American Association of Cancer Research, National American College of Physicians, National American Society for Clinical Oncology , National American Society of Hematology, National American Society of Human Genetics, National American Thyroid Association , National AstraZeneca, International Bayer Healthcare Pharmaceuticals and Bayer Scherring Pharma, International Bristol Meyers Squibb, National Eisai Inc., International Exelixis, International Genzyme, International GlaxoSmithKline, National International Thyroid Oncology Group, International NIH Study Section: NRSA Postdoctoral Fellowships in Genes, Genetics, and Genomics, National ONYX Pharmaceuticals, Inc., National OXiGENE, National Pennsylvania Society of Oncology and Hematology, Local The Endocrine Society, National University of Pennsylvania - American Cancer Society Pilot Program IRG, Local

Hospital Affiliation

Dr. Brose is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Marcia S. Brose MD PhD is an Associate Professor at the University Of Pennsylvania School Of Medicine, in the Departments of Otorhinolaryngology: Head and Neck Surgery, and Medicine, division of Hematology/Oncology. Over the past 5 years she has been the Director of the Thyroid Cancer Therapeutics Program. and in 2015 she was appointed the head of the Center for Rare Cancers and Personalized Therapy for the Abramson Cancer Center. She received her Medical Degree from Cornell University Medical College in 1995, and her PhD in Genetics in 1994 from the Rockefeller University in New York City. She then moved to the Hospital of the University of Pennsylvania where she completed her specialty training in Internal Medicine, and Hematology and Oncology, and postdoctoral work in cancer genetics. Dr. Brose’s current research interest includes the identification of novel treatments for advanced thyroid cancer, and she runs a clinical research unit and a laboratory aimed at identifying new therapeutic targets for solid tumors through genetic and molecular studies of tumor tissue. She started and currently runs the program for thyroid cancer therapeutics at the Abramson Cancer Center of the University of Pennsylvania, and was recently appointed the inaugural Director of the Center for Rare Cancers and Personalized Therapy, a unit aimed to bring the advances of new treatments recently approved for more common cancers to patients that have more rare diseases, or through identification of genetic signatures that identify them as possible candidates to new targeted agents.. She is currently the PI of several active clinical phase I-III clinical trials.

Dr. Brose is widely regarded as a pioneer of the new field of Thyroid Cancer Oncology. Prior to her work, there were no treatments for patients who had advanced disease. She is the global co-PI of DECISION, the pivotal international multi-institutional Phase III trial of sorafenib for patients with iodine refractory differentiated thyroid cancer which work was recognized with a plenary lecture to the American Society of Clinical Oncology in 2013 (with over 21,000 in attendance and widely reviewed online). The study was published in The Lancet and lead to the first FDA approved agent in this indication. She is also the PI of the international multicenter phase II study of vemurafenib in patients with RAI refractory papillary thyroid cancer that harbors the BRAFV600E mutations which is the first non-VEGF receptor TKI to show activity in this disease which was recently published in Lancet Oncology. She is a Co-Investigator and author of the pivotal phase III trials EXAM (cabozantinib in medullary thyroid cancer) and SELECT (lenvatinib in differentiated thyroid cancer) which were published in the Journal of Clinical Oncology and New England Journal of Medicine and both of which led to FDA approvals for Medullary and RAI refractory Differentiated Thyroid Cancer. She is an internationally recognized leader of the field of thyroid cancer oncology, and has been invited to lecture in the US, Europe, Asia, Central and South America on the emerging treatments for advanced thyroid cancers.
Her laboratory, which focuses on the correlative aspects of clinical trials has been a leader in identifying genetic markers of responses in clinical trials (Yarchoan et al 2016, and Brose et al, 2016).
She sees patients from across the US and Canada and abroad and regularly is invited to grand rounds to educate surgeons, endocrinologists and oncologists on how to incorporate the new systemic treatments for advanced thyroid cancer.

In summary, Dr. Brose’s research has led to new hope for patients with advanced thyroid cancer. Her work has laid the foundation for successful treatment approaches that are not only extending progression free survival, but overall survival as well.

Selected Publications:

Tuttle RM, Brose M.S., Grande E, Kim SW, Tahara M, Sabra MM.: Novel concepts for initiating multitargeted kinase inhibitors in radioactive iodine refractory differentiated thyroid cancer Best Pract Res Clin Endocrinol Metab. 31 (3): 295-305,2017.

Brose MS, Worden FP, Newbold KL, Guo M, Hurria A: Effect of Age on the Efficacy and Safety of Lenvatinib in Radioiodine-Refractory Differentiated Thyroid Cancer in the Phase III SELECT Trial J Clin Oncol 14 : 2017.

Brose MS, Smit J, Lin CC, Pitoia F, Fellous M, DeSanctis Y, Schlumberger M, Tori M, Sugitani I. : Timing of multikinase inhibitor initiation in differentiated thyroid cancer Endocr Relat Cancer 24 (5): 237-242,2017.

Grande, C., Visovsky,C., Brose, M.S.: The Challenges of Clinical Research in Rare Cancers: Bevacizumab Use in Low-Grade Serous Ovarian and Primary Peritoneal Cancers J Adv Pract Oncol 2017;8:388–391 8 : 388-391,2017.

Sherman, S.I., Clary, D.O., Elisei, R., Schlumberger, M.J., Cohen, E.E., Schoffski, P., Wirth, L.J., Mangeshkar, M., Aftab, D.T., Brose, M.S.: Correlative analyses of RET and RAS mutations in a phase 3 trial of cabozantinib in patients with progressive, metastatic medullary thyroid cancer. Cancer 122 (24): 3856-3864,2016.

D.S. Hong1, A. Dowlati2, H.A. Burris III, 3, J.J. Lee4, M.S. Brose5, A.F. Farago6, T.M. Bauer3, M. Taylor7, A.T. Shaw6, S. Smith8, N. Nanda8, S. Cruickshank8, M.C. Cox8, R. Doebele9: Clinical safety and activity from a phase 1 study of LOXO-101, a selective TRKA/B/C inhibitor, in solid-tumor patients with NTRK gene fusions European Society of Medical Oncology Asia Congress Annual Meeting 27 (Supplement 9): 2016.

Brose, M.S., Singh, N.: Vemurafenib for BRAFV600E-positive metastatic papillary thyroid cancer - Authors' response. Lancet Oncol 17 (11): e469,2016.

Brose MS, Singh N: Vemurafenib for BRAFV600E- positive metastatic papillary thyroid cancer- Author's response Lancel Oncol 17 (11): e469,2016.

Kappeler, C., Meinhardt, G., Elisei, R., Brose, M., Schlumberger, M.: Tumor growth rate analysis of progression-free survival (PFS) and overall survival (OS) for thyroid cancer patients receiving placebo or sorafenib in the phase 3 DECISION trial European Society for Medical Oncology 27 (Supplement 6): 2016.

Brose, M.S, Jarzab, B., Elisei, R., Giannetta, L, Bastholt, L., de la Fouchardiere, C., Pacini, F., Paschke, R., Nutting, C., Shong, Y.K., Sherman, S., Smit, J., Chung, J., Meinhard, G., Schlumberger, M., C. Kappeler16: Final overall survival analysis of patients with locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer (RAI-rDTC) treated with sorafenib in the phase 3 DECISION trial: An exploratory crossover adjustment analyses (poster discussion presentation) European Society for Medical Oncology 27 (Supplement 6): 2016.

View all publications

Academic Contact Info

Stellar Chance Building, Mezzanine

422 Curie Blvd.

Philadelphia, PA 19104
Phone: 215-746-6344
Fax: 215-898-2136
Patient appointments: 800-789-7366 (PENN)

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