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Marc A. Dichter, MD, PhD

Marc A. Dichter, MD, PhD Physician

Emeritus Professor of Neurology

Dr. Dichter is employed by Penn Medicine.

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About Dr. Marc A. Dichter

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012

Recognized by Best Doctors in America 2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012

Recognized in Philadelphia Magazine's May 2004, 2005, 2006, 2007 Top Docs issue

Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1978

Clinical Expertise:

  • Epilepsy

Practice Locations and Appointments

Insurance Accepted

  • OPR New Jersey Medicaid

Education and Training

Medical School: New York University School of Medicine
Residency: Beth Israel Deaconess Medical Center
Residency: Children's Hospital of Boston


1979 Ad Hoc Member of Neurological Sciences Study Section, NINCDS, 1987 Program Committee, Society for Neuroscience, 1994-1998 Chairman, Neurobiology of Disease Workshop, Society for Neuroscience, Professional Societies:,

Hospital Affiliation

Dr. Dichter is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.


Description of Research Expertise:

Hippocampus; culture; epilepsy; GABA; glutamate; synapse; plasticity; deep brain stimulation.

Epilepsy; epileptogenesis; cortical physiology; regulation of synaptic function; pharmacology of inhibitory and excitatory amino acid receptors

CNS tissue culture; intracellular recording; voltage clamping; patch clamping; immunohistochemistry; chronic eeg monitoring in small animals; brain stimulation

Research focuses on basic mechanisms of epilepsy, the physiology and pharmacology of synaptic transmission between hippocampal neurons, the developmental cell biology of cortical and hippocampal neurons maintained in cell culture, and characteristics of pleuripotent neural progenitor cells. Ongoing projects include methods for brain stimulation to prevent epileptic seizures, mechanisms of epileptogenesis, preventing epilepsy after traumatic brain injury or status epilepticus, mechanisms of progenitor cell differentiation into neurons.

Selected Publications:

O'Donnell, Lauren A. Agrawal, Arpita. Sabnekar, Praveena. Dichter, Marc A. Lynch, David R. Kolson, Dennis L.: Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury Journal of Neurochemistry 102 (6): 1905-17,2007.

Dalmau, Josep. Tuzun, Erdem. Wu, Hai-yan. Masjuan, Jaime. Rossi, Jeffrey E. Voloschin, Alfredo. Baehring, Joachim M. Shimazaki, Haruo. Koide, Reiji. King, Dale. Mason, Warren. Sansing, Lauren H. Dichter, Marc A. Rosenfeld, Myrna R. Lynch, David R.: Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.[see comment]. Annals of Neurology 61 (1): 25-36,2007.

Dichter, Marc A.: Innovative clinical trial designs for future antiepileptic drugs. Epilepsia 48 ( Suppl 1): 26-30,2007.

Tseng, Henry C. Ruegg, Stephan J. Maronski, Margaret. Messam, Conrad A. Grinspan, Judith B. Dichter, Marc A.: Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture. Neurobiology of Disease 22 (1): 88-97,2006.

O'Donnell, Lauren A. Agrawal, Arpita. Jordan-Sciutto, Kelly L. Dichter, Marc A. Lynch, David R. Kolson, Dennis L.: Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. Journal of Neuroscience 26 (3): 981-90,2006.

Dichter, Marc A.: Models of epileptogenesis in adult animals available for antiepileptogenesis drug screening. [Review] [34 refs] Epilepsy Research 68 (1): 31-5,2006.

Ding, Shinghua. Messam, Conrad A. Li, Peiying. Selzer, Michael E. Dichter, Marc A. Haydon, Philip G.: Murine brain progenitor cells have the ability to differentiate into functional neurons and integrate into the CNS. Cell Transplantation 15 (8-9): 699-710,2006.

Chen, Jinqiu. Tseng, Henry C. Dichter, Marc A. Zhang, Hongtao. Greene, Mark I.: Differential localization of ErbB receptor ensembles influences their signaling in hippocampal neurons. DNA & Cell Biology 24 (9): 553-62,2005.

Ances, Beau M. Vitaliani, Roberta. Taylor, Robert A. Liebeskind, David S. Voloschin, Alfredo. Houghton, David J. Galetta, Steven L. Dichter, Marc. Alavi, Abass. Rosenfeld, Myrna R. Dalmau, Josep.: Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates.[see comment]. Brain 128 (Pt 8): 1764-77,2005.

Tseng, Henry C. Dichter, Marc A.: Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons. Neurobiology of Disease 19 (1-2): 77-83,2005.

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Academic Contact Info

467 Stemmler Hall
Philadelphia, PA 19104-6077
Phone: (215) 349-5166
Patient appointments: 800-789-7366 (PENN)