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Marc A. Dichter, MD, PhD

Marc A. Dichter, MD, PhD Physician

Emeritus Professor of Neurology

Dr. Dichter is a Penn Medicine employed physician.

About Dr. Marc A. Dichter

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012

Recognized by Best Doctors in America 2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012

Recognized in Philadelphia Magazine's May 2004, 2005, 2006, 2007 Top Docs issue

Clinical Specialties

Specialty:

  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1978

Clinical Expertise:

  • Epilepsy

Description of Clinical Expertise

Clinical epilepsy, epilepsy in the aging population, the pharmacology of new antiepileptic drugs, anti-epileptogenesis after traumatic brain injury, biomarkers in neurodegenerative diseases.

Practice Locations and Appointments

  • Penn Neurology

    Penn Neuroscience Center Perelman Center for Advanced Medicine, South Pavilion, 2nd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: New York University School of Medicine
Residency: Beth Israel Deaconess Medical Center
Residency: Children's Hospital of Boston

Memberships

1979 Ad Hoc Member of Neurological Sciences Study Section, NINCDS 1980 Ad Hoc Member of Epilepsy Program Project Review Study Section 1982 Membership Committee, American Academy of Neurology 1986, 1989 Program Committee, American Neurological Association, 1987 Program Committee, Society for Neuroscience 1987 Neurological Sciences Study Section, NINCDS 1987 1991 Regular Member of Neurological Sciences (Subcommittee 2) Study Section, NINCDS 1989 1992 Chairman, American Epilepsy Society Annual Meeting Committee 1991-1992 Chairman, American Epilepsy Society Continuing Medical Education Committee, 1994- 1998 Chairman, Neurobiology of Disease Workshop, Society for Neuroscience 1996-1997 Chairman, North American Commission of ILAE 1998-2000 Program Committee, American Neurological Association 1999-2003 Reviewer for John Merck Fund Scholars Program in Neuroscience, Professional Societies: 1965 American Association for the Advancement of Science 1973 American Academy of Neurology 1977 Society for Neuroscience 1981 American Neurological Association 1986 American Epilepsy Society,

Hospital Affiliation

Dr. Dichter is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.

Research

Description of Research Expertise:

KEY WORDS:
Hippocampus; culture; epilepsy; GABA; glutamate; synapse; plasticity; deep brain stimulation.

RESEARCH INTERESTS
Epilepsy; epileptogenesis; cortical physiology; regulation of synaptic function; pharmacology of inhibitory and excitatory amino acid receptors


RESEARCH TECHNIQUES
CNS tissue culture; intracellular recording; voltage clamping; patch clamping; immunohistochemistry; chronic eeg monitoring in small animals; brain stimulation


RESEARCH SUMMARY
Research focuses on basic mechanisms of epilepsy, the physiology and pharmacology of synaptic transmission between hippocampal neurons, the developmental cell biology of cortical and hippocampal neurons maintained in cell culture, and characteristics of pleuripotent neural progenitor cells. Ongoing projects include methods for brain stimulation to prevent epileptic seizures, mechanisms of epileptogenesis, preventing epilepsy after traumatic brain injury or status epilepticus, mechanisms of progenitor cell differentiation into neurons.

Selected Publications:

O'Donnell, Lauren A. Agrawal, Arpita. Sabnekar, Praveena. Dichter, Marc A. Lynch, David R. Kolson, Dennis L.: Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury Journal of Neurochemistry 102 (6): 1905-17,2007.

Dalmau, Josep. Tuzun, Erdem. Wu, Hai-yan. Masjuan, Jaime. Rossi, Jeffrey E. Voloschin, Alfredo. Baehring, Joachim M. Shimazaki, Haruo. Koide, Reiji. King, Dale. Mason, Warren. Sansing, Lauren H. Dichter, Marc A. Rosenfeld, Myrna R. Lynch, David R.: Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.[see comment]. Annals of Neurology 61 (1): 25-36,2007.

Dichter, Marc A.: Innovative clinical trial designs for future antiepileptic drugs. Epilepsia 48 (Suppl 1): 26-30,2007.

Tseng, Henry C. Ruegg, Stephan J. Maronski, Margaret. Messam, Conrad A. Grinspan, Judith B. Dichter, Marc A.: Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture. Neurobiology of Disease 22 (1): 88-97,2006.

O'Donnell, Lauren A. Agrawal, Arpita. Jordan-Sciutto, Kelly L. Dichter, Marc A. Lynch, David R. Kolson, Dennis L.: Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. Journal of Neuroscience 26 (3): 981-90,2006.

Dichter, Marc A.: Models of epileptogenesis in adult animals available for antiepileptogenesis drug screening. [Review] [34 refs] Epilepsy Research 68 (1): 31-5,2006.

Ding, Shinghua. Messam, Conrad A. Li, Peiying. Selzer, Michael E. Dichter, Marc A. Haydon, Philip G.: Murine brain progenitor cells have the ability to differentiate into functional neurons and integrate into the CNS. Cell Transplantation 15 (8-9): 699-710,2006.

Chen, Jinqiu. Tseng, Henry C. Dichter, Marc A. Zhang, Hongtao. Greene, Mark I.: Differential localization of ErbB receptor ensembles influences their signaling in hippocampal neurons. DNA & Cell Biology 24 (9): 553-62,2005.

Ances, Beau M. Vitaliani, Roberta. Taylor, Robert A. Liebeskind, David S. Voloschin, Alfredo. Houghton, David J. Galetta, Steven L. Dichter, Marc. Alavi, Abass. Rosenfeld, Myrna R. Dalmau, Josep.: Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates.[see comment]. Brain 128 (Pt 8): 1764-77,2005.

Tseng, Henry C. Dichter, Marc A.: Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons. Neurobiology of Disease 19 (1-2): 77-83,2005.

View all publications

Academic Contact Info

467 Stemmler Hall
Philadelphia, PA 19104-6077
Phone: (215) 349-5166
Fax: (215) 573-2107
Patient appointments: 800-789-PENN (7366)

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