Description of Research Expertise:
Hippocampus; culture; epilepsy; GABA; glutamate; synapse; plasticity; deep brain stimulation.
Epilepsy; epileptogenesis; cortical physiology; regulation of synaptic function; pharmacology of inhibitory and excitatory amino acid receptors
CNS tissue culture; intracellular recording; voltage clamping; patch clamping; immunohistochemistry; chronic eeg monitoring in small animals; brain stimulation
Research focuses on basic mechanisms of epilepsy, the physiology and pharmacology of synaptic transmission between hippocampal neurons, the developmental cell biology of cortical and hippocampal neurons maintained in cell culture, and characteristics of pleuripotent neural progenitor cells. Ongoing projects include methods for brain stimulation to prevent epileptic seizures, mechanisms of epileptogenesis, preventing epilepsy after traumatic brain injury or status epilepticus, mechanisms of progenitor cell differentiation into neurons.
O'Donnell, Lauren A. Agrawal, Arpita. Sabnekar, Praveena. Dichter, Marc A. Lynch, David R. Kolson: Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury Journal of Neurochemistry 102 (6): 1905-17,2007.
Dalmau, Josep. Tuzun, Erdem. Wu, Hai-yan. Masjuan, Jaime. Rossi, Jeffrey E. Voloschin, Alfredo. Baehring, Joachim M. Shimazaki, Haruo. Koide, Reiji. King, Dale. Mason, Warren. Sansing, Lauren H. Dichter, Marc A. Rosenfeld, Myrna R. Lynch: Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.[see comment]. Annals of Neurology 61 (1): 25-36,2007.
Dichter: Innovative clinical trial designs for future antiepileptic drugs. Epilepsia 48 (Suppl 1): 26-30,2007.
Tseng, Henry C. Ruegg, Stephan J. Maronski, Margaret. Messam, Conrad A. Grinspan, Judith B. Dichter: Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture. Neurobiology of Disease 22 (1): 88-97,2006.
O'Donnell, Lauren A. Agrawal, Arpita. Jordan-Sciutto, Kelly L. Dichter, Marc A. Lynch, David R. Kolson: Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. Journal of Neuroscience 26 (3): 981-90,2006.
Dichter: Models of epileptogenesis in adult animals available for antiepileptogenesis drug screening. [Review] [34 refs] Epilepsy Research 68 (1): 31-5,2006.
Ding, Shinghua. Messam, Conrad A. Li, Peiying. Selzer, Michael E. Dichter, Marc A. Haydon: Murine brain progenitor cells have the ability to differentiate into functional neurons and integrate into the CNS. Cell Transplantation 15 (8-9): 699-710,2006.
Chen, Jinqiu. Tseng, Henry C. Dichter, Marc A. Zhang, Hongtao. Greene: Differential localization of ErbB receptor ensembles influences their signaling in hippocampal neurons. DNA & Cell Biology 24 (9): 553-62,2005.
Ances, Beau M. Vitaliani, Roberta. Taylor, Robert A. Liebeskind, David S. Voloschin, Alfredo. Houghton, David J. Galetta, Steven L. Dichter, Marc. Alavi, Abass. Rosenfeld, Myrna R. Dalmau: Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates.[see comment]. Brain 128 (Pt 8): 1764-77,2005.
Tseng, Henry C. Dichter: Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons. Neurobiology of Disease 19 (1-2): 77-83,2005.
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