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Malek Kamoun, MD, PhD

Malek Kamoun, MD, PhD Physician

Director, Clinical Immunology and Histocompatibility Laboratory Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Languages spoken:

  • Arabic
  • French

Dr. Kamoun is employed by Penn Medicine.

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About Dr. Malek Kamoun

My areas of clinical expertise:

Clinical laboratory immunology: Diagnostic tests used in the evaluation of autoimmune diseases, infectious diseases, and immune deficiencies. 

Clinical histocompatibility testing:  HLA genotyping and HLA antibody testing used for the evaluation of solid organ and allogeneic bone marrow/hematopoietic cell transplantion and donor selection.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Immunopathology, 1983
  • Pathology - Clinical Pathology, 1981

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Paris - Pierre et Marie Curie
Residency: University Pierre and Marie Curie Paris VI
Fellowship: University Pierre and Marie Curie Paris VI
Residency: University of Washington Hospital and Clinics
Fellowship: University of Washington Hospital and Clinics


Academy of Clinical Laboratory Physicians and Scientists (ACLPS), National American Association of Immunologists, American Association of Pathologists, American Society for Blood and Marrow Transplantation, National American Society for Clinical Histocompatibility and Immunogenetics (ASHI), National American Society of Clinical Pathologists, American Society of Transplant Physicians, National Clinical Immunology Society, College of American Pathologist, Federation of Clinical Immunology Societies, National Immucor, National Luminex, National National Institutes of Health, National Kidney Registry, National Omixon, National The Food and Drug Administration (FDA) and The U.S. Department of Health and Human Services (HHS), United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation Network (OPTN), National

Hospital Affiliation

Dr. Kamoun is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Research Interests: HLA genes and molecules in clinical transplantation

Keywords: Human immunogenetics, HLA genes and molecules. Clinical Histocompatibility, clinical transplantation, autoimmunity.

Research Summary:

Dr. Kamoun's research interest is to define the extent and nature of HLA haplotype genetic diversity and to understand the biological relevance of amino acid polymorphism in HLA class I and class II molecules. Computational and biostatical methods are used to evaluate the significance of HLA amino acid polymorphism in clinical transplantation and autoimmunity.

Another interest is to better understand the impact of B cell alloresponse and anti-HLA antibodies on allograft outcomes in clinical transplantation including islet cell transplantation. Clinical trials are used to assess the effectiveness of B cell depleting agents on alloantibody levels and allograft survival in transplant recipients.

Selected Publications:

Kamoun M, Holmes JH, Israni AK, Kearns JD, Teal V, Yang WP, Rosas SE, Joffe MM, Li H, Feldman HI: HLA-A amino acid polymorphism and delayed kidney allograft function Proc Natl Acad Sci U S A 105 (48): 18883-8,2008.

Nikaein A, Cherikh W, Nelson K, Baker T, Leffell S, Bow L, Crowe D, Connick K, Head MA, Kamoun M, Kimball P, Klohe E, Noreen H, Rebellato L, Sell T, Sullivan K, Land G: Organ Procurement and Transplantation Network/United Network for Organ Sharing Histocompatibility Committee collaborative study to evaluate prediction of crossmatch results in highly sensitized patients Transplantation 87 (4): 557-62,2009.

Harris RA, Sugimoto K, Kaplan DE, Ikeda F, Kamoun M, Chang KM: Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans Hepatology 48 (1): 70-9,2008.

Sutter JA, Kwan-Morley J, Dunham J, Du YZ, Kamoun M, Albert D, Eisenberg RA, Luning Prak ET: A longitudinal analysis of SLE patients treated with rituximab (anti-CD20): factors associated with B lymphocyte recovery Clin Immunol 126 (3): 282-90,2008.

Goral S, Prak EL, Kearns J, Bloom RD, Pierce E, Doyle A, Grossman R, Naji A, Kamoun M: Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation Nephrol Dial Transplant 23 (1): 390-2,2008.

Kamoun M, Israni AK, Joffe MM, Hoy T, Kearns J, Mange KC, Feldman D, Goodman N, Rosas SE, Abrams JD, Brayman KL, Feldman HI: Assessment of differences in HLA-A, -B, and -DRB1 allele mismatches among African-American and non-African-American recipients of deceased kidney transplants Transplant Proc 39 (1): 55-63,2007.

Rickels MR, Kamoun M, Kearns J, Markmann JF, Naji A: Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity J Clin Endocrinol Metab 92 (7): 2410-4,2007.

Monos D, Heliopoulos J, Argyris E, Cordopatis P, Zompra A, Kamoun M: Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displayed random peptide library J Mol Recognit 19 (6): 535-41,2006.

Narula S, LaRosa DF, Kamoun M, Dalmau J, Levinson AI: Progressive multifocal leukoencephalopathy in a patient with common variable immunodeficiency and abnormal CD8+ T-cell subset distribution Ann Allergy Asthma Immunol 98 (5): 483-9,2007.

Luning Prak ET, Young DS, Kamoun M, Nachamkin I, Alexander CB, Spitalnik SL, Peerschke EI, Smith BR: 2008 ACLPS panel discussion on resident education in clinical pathology Am J Clin Pathol 131 (5): 618-22,2009.

View all publications

Academic Contact Info

Hospital of the University of Pennsylvania
7.020 Founders Pavilion
3400 Spruce St.

Philadelphia, PA 19104-4238
Phone: (215) 614-1902
Patient appointments: 800-789-7366 (PENN)

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