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Lucy M. De La Cruz, MD

Lucy M. De La Cruz, MD Physician

Assistant Professor of Clinical Surgery

Languages spoken:

  • Portuguese
  • Spanish

Dr. De La Cruz is employed by Penn Medicine.

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There is no publicly available rating for this medical professional for one of the following reasons:

  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
  3. He or she sees patients but has not yet received the minimum 30 patient satisfaction reviews in the past 12 months, ensuring that the rating is statistically reliable and a true reflection of patient satisfaction.

Clinical Specialties


  • Endocrine and Oncologic Surgery

Programs & Centers:

Board Certification:

  • Surgery, 2016

Clinical Expertise:

  • Axillary Lymph Node Dissection
  • Breast Cancer
  • Breast Cancer Evaluation
  • Breast Cancer Risk Reduction
  • Breast Cancer Screening
  • Breast Conserving Surgery (Lumpectomy)
  • Breast Cysts
  • Breast Diseases
  • Breast Disorders
  • Breast Exam
  • Breast Lumps and Tumors
  • Breast Lymph Node Mapping
  • Breast Pain
  • Breast Surgery
  • Cancer Prevention and Early Detection
  • Ductal Carcinoma in Situ (DCIS)
  • Fibroadenoma (Benign Breast Tumor)
  • Invasive (Infiltrating) Ductal Carcinoma (IDC)
  • Invasive (Infiltrating) Lobular Carcinoma (ILC)
  • Invasive Breast Cancer
  • Lobular Carcinoma In Situ (LCIS)
  • Malignant Breast Disease
  • Nipple Discharge
  • Nipple-Sparing Mastectomy (NSM)
  • Non-Cosmetic Breast Surgery
  • Prophylactic Mastectomy
  • Sentinel Lymph Node Mapping and Biopsy
  • Skin-Sparing Mastectomy

Description of Clinical Expertise


Practice Locations and Appointments

  • Rena Rowan Breast Center

    Abramson Cancer Center Perelman Center for Advanced Medicine, West Pavilion, 3rd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Universidad Central Del Este
Residency: Jackson Health System - Jackson Memorial
Residency: University of Miami Hospital and Clinic


American College of Surgeons, National American Society of Breast Surgeons, National Society of Surgical Oncology, National Women in Surgery, National

Hospital Affiliation

Dr. De La Cruz is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Yoon-Flannery K, Destefano L, De La Cruz L, Fisher C, Lin L, Coffua L, Mustafa R, Sataloff D, Tchou J, Brooks A: Quality of life after nipple sparing mastectomy: A prospective study of patients using the Breast Q Journal of Surgical Oncology : 2018.

De La Cruz LM, Harhay MO, Zhang P, Ugras S.: Impact of Neoadjuvant Chemotherapy on Breast Cancer Subtype: Does Subtype Change and, if so, How? : IHC Profile and Neoadjuvant Chemotherapy. annals of surgical oncology : 2018.

De La Cruz L, Czerniecki B: Immunotherapy for Breast Cancer is Finally at the Doorstep: Immunotherapy in Breast Cancer Annals of Surgical Oncology : 2018.

De La Cruz LM, Shulman LN.: 'Under' Surveillance: Impact of Race and Socioeconomic Status on Post-Treatment Breast Cancer Imaging. ANNALS OF SURGICAL ONCOLOGY : 2018.

Williams AD, Reyes SA, Arlow RL, Tchou J, De La Cruz LM: Is Age Trumping Genetic Profiling in Clinical Practice? Relationship of Chemotherapy Recommendation and Oncotype DX Recurrence Score in Patients Aged < 50 Years versus ≥ 50 Years, and Trends Over Time. ANNALS OF SURGICAL ONCOLOGY : 2018.

So A, De La Cruz LM, Williams AD, Bahng J, Liao G, McDonald ES, Fisher CS, Czerniecki BJ, Sataloff D, Tchou J.: The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience. journal of surgical oncology : 2018.

Nocera NF, Pyfer BJ, De La Cruz LM, Chatterjee A, Thiruchelvam PT, Fisher CS.: NSQIP Analysis of Axillary Lymph Node Dissection Rates for Breast Cancer: Implications for Resident and Fellow Participation. JOURNAL OF SURGICAL EDUCATION : 2018.

Mustafa R, DeStefano L, Yoon-Flannery K, Fisher CS, Zhang PJ, Tchou J, Czerniecki BJ, De La Cruz L: Evaluating the upstaging risk of HER2 positive DCIS to invasive breast cancer: A matched cohort Annals of Surgical Oncology : 2017.

De La Cruz, LM: Nationwide Comparison of Autologous vs. Implant-Based Post-Mastectomy Reconstruction. Poster Presentation Plastic Surgery Research Council 62nd Annual Meeting, Durham, North Carolina. : 2017.

Mustafa R, DeStefano L, Bahng J, Yoon-Flannery K, Fisher C, Tchou J, Zhang P, Czerniecki BJ, De La Cruz LM: Evaluating the upstaging risk of HER2 positive DCIS to invasive breast cancer: A matched cohort Annals of Surgical Oncology 24 (2 Suppl 1): 85-86,2017.

Academic Contact Info

Perelman Center for Advanced Medicine
3400 Civic Center BLVD
South Pavilion, Office 10-181

philadelphia, PA 19104
Phone: (215) 615-6833
Patient appointments: 800-789-7366 (PENN)