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Leslie Shaw, PhD

Leslie Shaw, PhD Pathologist

Director, Clinical Toxicology Laboratory Interim Director, Clinical Chemistry Section Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Shaw is employed by Penn Medicine.

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About Dr. Leslie Shaw

Received the Penn Medicine Award of Excellence, 2006

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Description of Clinical Expertise

Measurement and interpretation of the toxicokinetics of drugs and toxins in patients affected by them. Interpretation of the pharmacokinetics of immunosuppressant maintenance medications in transplant patients.

Practice Locations and Appointments

Insurance Accepted

  • OPR Medicare
  • OPR New Jersey Medicaid
  • OPR Pennsylvania Medicaid

Education and Training

Graduate School: SUNY Upstate Medical University
Fellowship: Johns Hopkins Hospital
Fellowship: Hospital of the University of Pennsylvania


Alzheimers Association Global Biomarker Standardization Consortium., International Alzheimers Association, International American Association for Clinical Chemistry, National American Association for the Advancement of Science, National American Chemical Society, National Cerebrospinal Fluid appropriate Use, Criteria Workgroup, Alzheimers Association., International Eli Lilly, International International Association for Therapeutic Drug Monitoring and Clinical Toxicology, International International Federation of Clinical Chemistry, International National Academy of Clinical Biochemistry:, International Philadelphia Section, American Association for Clinical Chemistry: 1996 (Program Chairman)., Local Philadelphia Section, American Association for Clinical Chemistry:, Local Roche (Member of Scientific Advisory Board), International Therapeutic Drug Monitoring and Clinical Toxicology Division of the AACC:, National

Hospital Affiliation

Dr. Shaw is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Development, validation and implementation of neurodegenerative diseases biomarkers in cerebrospinal fluid and plasma into treatment trials and clinical studies (eg, ADNI study; PPMI study). These studies include the use of manual and highly automated immunoassays and for amyloid beta(1-42) and for total tau the use of high sensitivity UPLC/tandem mass spectrometry. Multi-modal statistical analyses of these study data to address several questions including the diagnostic utilities of these biomarkers; assessments of the longitudinal trajectories of these biomarkers in AD, MCI and cognitively normal controls to assess the neuropathological changes over time in these individuals.

Selected Publications:

Hansson O, Seibyl J, Stomrud E, Zetterberg H, Trojanowski JQ, Bittner T, Lifke V, Corradini V, Eichenlaub U, Batrla R, Buck K, Zink K, Rabe C, Blennow K, Shaw LM.: CSF biomarkers of Alzheimer’s disease concord with amyloid-B PET and predict clinical progression: A study of fully-automated immunoassays in BioFINDER and ADNI cohorts. Alzheimer's and Dementia - In Press. : 2018, in Press.

Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA.: Cerebrospinal fluid tau, AB and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimer's and Dementia : 2018, in Press.

Portelius E, Olsson B, Hoglund K, Cullen NC, Kvartsberg H, Andreasson U, Zetterberg H, Sandelius A, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, McBride J, Toledo JB, Trojanowski JQ, Blennow K.: Cerebrospinal Fluid Neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta Neuropathologica : 2018, in Press.

Shaw LM, Arias J, Blennow K, Galasko D, Molinuevo JL, Salloway S, Schindler S, Carrillo MC, Hendrix JA, Ross A, Illes J, Ramus C, Fifer S.: Appropriate Use Criteria for Lumbar Puncture and Cerebrospinal Fluid Testing in the Diagnosis of Alzheimer's Disease. Alzheimer's and Dementia : 2018, in Press.

Phillips JS, Da Re F, Dratch L, Xie SX, Irwin DJ, McMillan CT, Vaishnavi SN, Ferrarese C, Lee EB, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M.: Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiology of Aging. 63 : 2018, in Press.

Shi M, Tang L, Toledo JB, Ginghina C, Wang H, Aro P, Jensen PH, Weintraub D, Chen-Plotkin AS, Irwin DJ, Grossman M, McCluskey L, Elman LB, Wolk DA, Lee EB, Shaw LM, Trojanowski JQ, Zhang J.: Cerebrospinal Fluid a-synuclein contributes to the differential diagnosis of Alzheimer's Disease. Alzheimer's and Dementia : 2018, in Press.

Hansson O, Mikulskis A, Fagan AM, Teunissen C, Zetterberg H, Vanderstichele H, Molinuevo JL, Shaw LM, Vandijck M, Verbeek MM, Savage M, Mattson N, Lewczuk P, Batrla R, Rutz S, Deam RA, Blennow K.: The Impact of preanalytical Variables on measuring Cerebrospinal Fluid biomarkers for Alzheimer's Disease diagnosis: a Review. Alzheimer's and Dementia : 2018, in Press.

Shaw LM, Waligorska T, Fields L, Korecka M, Figurski M, Trojanowski JQ, Eichenlaub U, Wahl S, Quan M, Pontecorvo MJ, Lachno DR, Talbot JA, Andersen SW, Siemers ER, Dean RA.: Derivation of cut-offs for the Elecsys Amyloid B (1-42) assay in Alzheimer's Disease. Alzheimer's and Dementia, In Press : 2018, in Press.

Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Seppi K: Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 90 (2): 2018.

Irwin DJ, Sharon X Xie, Coughlin D, Nevier N, Akhtar R, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM, Grossman M, and Trojanowski JQ.: CSF Tau and Amyloid-Beta Predict Cerebral Synucleinopathy in Autopsied Lewy Body Disorders. Neurology. 90 : 1-9,2018.

Academic Contact Info

Hospital of the University of Pennsylvania
7.103 Founders Pavilion 3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-6575
Patient appointments: 800-789-7366 (PENN)

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