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Leslie Shaw, PhD

Leslie Shaw, PhD Pathologist

Director, Clinical Toxicology Laboratory
Interim Director, Clinical Chemistry Section
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Shaw is a Penn Medicine employed physician.

About Dr. Leslie Shaw

Received the Penn Medicine Award of Excellence, 2006

Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Description of Clinical Expertise

Measurement and interpretation of the toxicokinetics of drugs and toxins in patients affected by them. Interpretation of the pharmacokinetics of immunosuppressant maintenance medications in transplant patients.

Practice Locations and Appointments

Education and Training

Graduate School: SUNY Upstate Medical University
Fellowship: Johns Hopkins Hospital
Fellowship: Hospital of the University of Pennsylvania

Memberships

AACC/NACB Task Force on Cyclosporine Monitoring, National Alpha Sigma Nu, National Jesuit Honor Society, Alzheimers Association Global Biomarker Standardization Consortium., International Alzheimers Association, International American Association for Clinical Chemistry, American Association for the Advancement of Science, American Association of Pathologists, American Chemical Society, American Society for Clinical Pharmacology and Therapeutics:, American Society for Mass Spectroscopy, Eli Lilly, International International Association for Therapeutic Drug Monitoring and Clinical Toxicology, International Federation of Clinical Chemistry, International International Federation on Clinical Chemistry, National Academy of Clinical Biochemistry:, NCCLS Area Committee on Toxicology and Drug Monitoring, Philadelphia Section, American Association for Clinical Chemistry: 1996 (Program Chairman). Philadelphia Section, American Association for Clinical Chemistry: 1978, Local Philadelphia Section, American Association for Clinical Chemistry:, Local Society of Toxicology, 2004 - Present, Therapeutic Drug Monitoring and Clinical Toxicology Division of the AACC:, National

Hospital Affiliation

Dr. Shaw is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania
  • Penn Presbyterian Medical Center
  • Pennsylvania Hospital

Research

Description of Research Expertise:

Development, validation and implementation of neurodegenerative diseases biomarkers in cerebrospinal fluid and plasma into treatment trials and clinical studies (eg, ADNI study; PPMI study). These studies include the use of manual and highly automated immunoassays and for amyloid beta(1-42) and for total tau the use of high sensitivity UPLC/tandem mass spectrometry. Multi-modal statistical analyses of these study data to address several questions including the diagnostic utilities of these biomarkers; assessments of the longitudinal trajectories of these biomarkers in AD, MCI and cognitively normal controls to assess the neuropathological changes over time in these individuals.

Selected Publications:

Durazzo TC, Korecka M, Trojanowski JQ, Weiner MW, O'Hara R, Ashford JW, Shaw LM, Alzheimer's Disease Neuroimaging Initiative.: Active Cigarette smoking in cognitively-normal elders and probable Alzheimer's Disease is associated with Elevated Cerebrospinal fluid Oxidative Stress biomarkers. J Alzheimers Dis. : 2016.

Bjerke M, Andreasson U, Kuhlman J, Portelius E, Pannee J, Lewczuk P, Umek RM, Vanmechelen E, Vanderstichele H, Stoops E, Lewis J, Vandijck M, Kostanjevecki V, Jeromin A, Salamone SJ, Schmidt O, Matzen A, Madin K, Eichenlaub U, Bittner T, Shaw LM, Zegers I, Zetterberg H, Blennow K.: Assessing the commutability of reference material formats for the harmonization of amyloid-B measurements. Clin Chem Lab Med. 54 (7): 2016.

Kang JH, Mollenhauer B, Coffey CS, Toledo JB, Weintraub D, Galasko DR, Irwin DJ, Van Deerlin V, Chen-Plotkin AS, Caspell-Garcia C, Waligorska T, Taylor P, Shah N, Pan S, Zero P, Frasier M, Marek K, Kieburtz K, Jennings D, Tanner CM, Simuni T, Singleton A, Toga AW, Chowdhury S, Trojanowski JQ, Shaw LM; Parkinson's Progression Marker Initiative.: CSF Biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study. Acta Neuropathol. 131 (6): 935-49,2016.

Vilas D, Shaw LM, Taylor P, Berg D, Brockman K, Aasly J, Marras C, Pont-Sunyer C, Rios J, Marek K, Tolosa E.: Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers. Mov Disord. 31 (6): 906-14,2016.

Podlesniy P, Vilas D, Taylor P, Shaw LM, Tolosa E, Trullas R.: Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease. Neurobiol Dis. 94 : 10-17,2016.

Van Broeck B, Timmers M, Ramael S, Bogert J, Shaw LM, Mercken M, Slemmon J, Van Nueten L, Engelborghs S, Streffer JR.: Impact of frequent cerebrospinal fluid sampling on AB levels: systematic approach to elucidate influencing factors. Alzheimers Res Ther. 8 (1): 2016.

Kuhlmann J, Andreasson U, Pannee J, Bjerke M, Portelius E, Leinerbach A, Bittner T, Korecka M, Jenkins RG, Vanderstichele H, Stoops E, Lewczuk P, Shaw LM, Zegers I, Schimmel H, Zetterberg H, Blennow K, IFCC Working Group on Standarization of CSF Proteins (WG-CSF).: CSF AB1-42 - an excellent but complicated Alzheimer's biomarker - a route to standardization. Clin Chim Acta. : 2016.

Abner EL, Jicha GA, Shaw LM, Trojanowski JQ, Goetzl EJ.: Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging. Ann Clin Transl Neurol. 3 (5): 399-403,2016.

berger M, Nadler JW, Friedman A, McDonagh DL, Bennett ER, Cooter M, Qi W, Laskowitz DT, Ponnusamy V, Newman MF, Shaw LM, Warner DS, Matjew JP, James ML; MAD-PIA trial team.: The effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal fluid markers of Alzheimer's Disease: Results of a Randomized trial. J Alzheimers Dis. 52 (4): 1299-310,2016.

Pannee J, Gobom J, Shaw LM, Korecka M, Chambers EE, Lame M, Jenkins R, Mylott W, Carrillo MC, Zegers I, Zetterberg H, Blennow K, Portelius E.: Round robin test on quantification of amyloid-B 1-42 in cerebrospinal fluid by mass spectrometry. Alzheimer's & Dementia 12 (1): 55-9,2016.

Academic Contact Info

Hospital of the University of Pennsylvania
7.103 Founders Pavilion 3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-6575
Fax: (215) 662-7529

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