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Leslie Shaw, PhD

Leslie Shaw, PhD Pathologist

Director, Clinical Toxicology Laboratory Interim Director, Clinical Chemistry Section Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Shaw is employed by Penn Medicine.

About Dr. Leslie Shaw

Received the Penn Medicine Award of Excellence, 2006

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Description of Clinical Expertise

Measurement and interpretation of the toxicokinetics of drugs and toxins in patients affected by them. Interpretation of the pharmacokinetics of immunosuppressant maintenance medications in transplant patients.

Practice Locations and Appointments

Insurance Accepted

  • OPR Medicare
  • OPR New Jersey Medicaid
  • OPR Pennsylvania Medicaid

Education and Training

Graduate School: SUNY Upstate Medical University
Fellowship: Johns Hopkins Hospital
Fellowship: Hospital of the University of Pennsylvania


Alzheimers Association , International Alzheimers Association Global Biomarker Standardization Consortium., International American Association for Clinical Chemistry, National American Association for the Advancement of Science, National American Chemical Society, National Cerebrospinal Fluid appropriate Use, Criteria Workgroup, Alzheimers Association. , International Eli Lilly, International International Association for Therapeutic Drug Monitoring and Clinical Toxicology, International International Federation of Clinical Chemistry, International National Academy of Clinical Biochemistry:, International Philadelphia Section, American Association for Clinical Chemistry: 1996 (Program Chairman)., Local Philadelphia Section, American Association for Clinical Chemistry:, Local Roche (Member of Scientific Advisory Board), International Therapeutic Drug Monitoring and Clinical Toxicology Division of the AACC:, National

Hospital Affiliation

Dr. Shaw is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Development, validation and implementation of neurodegenerative diseases biomarkers in cerebrospinal fluid and plasma into treatment trials and clinical studies (eg, ADNI study; PPMI study). These studies include the use of manual and highly automated immunoassays and for amyloid beta(1-42) and for total tau the use of high sensitivity UPLC/tandem mass spectrometry. Multi-modal statistical analyses of these study data to address several questions including the diagnostic utilities of these biomarkers; assessments of the longitudinal trajectories of these biomarkers in AD, MCI and cognitively normal controls to assess the neuropathological changes over time in these individuals.

Selected Publications:

Goldman JG, Andrews H, Amara A, Naito A, Alcalay RN, Shaw LM, Taylor P, Xie T, Tuite P, Henchcliffe C, Hogarth P, Frank S, Dain-Hilaire M-H, Frasier M, Arnedo V, Reimer AN, Sutherland M, Swanson-Fischer C, Gwinn K: CSF, Plasma, and saliva in the BioFIND Study: relationships among biomarkers and Parkinson's disease features. Movement Disorders, in Press. : 2017, In Press..

Irwin DJ, Sharon X Xie, Coughlin D, Nevier N, Akhtar R, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM: CSF Tau and Amyloid-Beta Predict Cerebral Synucleinopathy in Autopsied Lewy Body Disorders. Neurology, in Press. : 2017, In Press.

Deters KD, Risacher SL, Kim S, Nho K, West JD, Blennow K, Zetterberg H, Shaw LM, Trojanowski JQ, Weiner MW: Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's Disease. 58 : 1245-1254,2017.

Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu I-W, Zhang Y, Nalls M, Singleton A, Shaw LM, Kang J-H, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D: Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson Disease. PLOS One 12 (5): 2017.

CSF Biomarkers for Alzheimer Disease - approaching consensus. Nature Reviews / NEUROLOGY : 2017.

Durazzo TC, Korecka M, Trojanowski JQ, Weiner MW, O'Hara R, Ashford JW, Shaw LM: Active Cigarette smoking in cognitively-normal elders and probable Alzheimer's Disease is associated with Elevated Cerebrospinal fluid Oxidative Stress biomarkers. J Alzheimers Dis. : 2016.

Bjerke M, Andreasson U, Kuhlman J, Portelius E, Pannee J, Lewczuk P, Umek RM, Vanmechelen E, Vanderstichele H, Stoops E, Lewis J, Vandijck M, Kostanjevecki V, Jeromin A, Salamone SJ, Schmidt O, Matzen A, Madin K, Eichenlaub U, Bittner T, Shaw LM, Zegers I, Zetterberg H: Assessing the commutability of reference material formats for the harmonization of amyloid-B measurements. Clin Chem Lab Med. 54 (7): 2016.

Kang JH, Mollenhauer B, Coffey CS, Toledo JB, Weintraub D, Galasko DR, Irwin DJ, Van Deerlin V, Chen-Plotkin AS, Caspell-Garcia C, Waligorska T, Taylor P, Shah N, Pan S, Zero P, Frasier M, Marek K, Kieburtz K, Jennings D, Tanner CM, Simuni T, Singleton A, Toga AW, Chowdhury S, Trojanowski JQ: CSF Biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study. Acta Neuropathol. 131 (6): 935-49,2016.

Vilas D, Shaw LM, Taylor P, Berg D, Brockman K, Aasly J, Marras C, Pont-Sunyer C, Rios J, Marek K: Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers. Mov Disord. 31 (6): 906-14,2016.

Podlesniy P, Vilas D, Taylor P, Shaw LM, Tolosa E: Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease. Neurobiol Dis. 94 : 10-17,2016.

Academic Contact Info

Hospital of the University of Pennsylvania
7.103 Founders Pavilion 3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-6575
Patient appointments: 800-789-7366 (PENN)

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