Description of Research Expertise:
Dr. Laudanski's research focuses on the three distinctive areas: regulation of DNA expression in survivors after critical care illnesses, health care operations/medical decision making processes, and medical volunteerism. On the first subject, he is a PI on the NIH-funded project focusing on the long-term regulation of gene expression after a critical care event and the impact on the recovery of the patient after critical care illness and anesthesia/surgery. He is also very interested in medical decision making and health care operations as the primary determinant of patient recovery. His research investigates the cognitive process, biases and the effect of emotional imprints on the decisions made by medical professionals. His work showed that suboptimal decision making processes may expose patients to unnecessary risk and have negative economic consequences for hospital systems. Optimizing health care in the ICU is another area of interest. The ICU environment is demanding with significant swings in demand. Improving existing health care models, or envisioning new health care models, may have a potentially significant impact on individual and population health. Dr. Laudanski is particularly interested in tele-ICU, especially in terms of integration with wearable devices and alternative models of health care delivery. He uses simulation, narrative studies, and cognitive testing to discover operating problems and provide the staff with unique experiences. Finally, adjusting health care operations and delivery based on the availability, cultural specificity, and local demands is another area of interest that is frequently pursued by Kris in the austere and remote settings.
Laudanski K, Zawadka M, Polosak J, Modi J, DiMeglio M, Gutsche J, Szeto WY, Puzianowska-Kuzmicka M: Acquired immunological imbalance after surgery with cardiopulmonary bypass due to to epigenetic over-activation of PU.1/M-CSF Journal of Translational Medicine 143 (16): 1-13,2018.
Laudanski K, Lapko N, Zawadka M, Danet-Desnoyer G, Worthen GS: The clinical and immunological performance of 28 days survival model of cecal ligation and puncture in humanized mice PLoS One 12 (7): e0180377,2017.
Lapko N, Zawadka M, Polosak J, Worthen GS, Danet-Desnoyers G, Puzianowska-Kuzmicka M, Laudanski K: Long-term monocyte dysfunction after sepsis in humanized mice is related to persisted activation of M-CSF and demethylation of PU.1 and it can be reversed by blocking M-CSF in vitro or by transplanting naïve autologous stem cells in vivo Frontiers in Immunology 8 : 401-412,2017.
Zawadka M, Wahome J, Oszkiel H, Szeto WY, Cobb B, Laudanski K: Long-term alterations in monocyte function after elective cardiac surgery Anaesthesia 72 (7): 879-888,2017.
Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG: Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways Proceedings of the National Academy of Sciences of the United States of America 103 (42): 15564-15569,2006.
Laudanski K, Eckenhoff R: Anesthesia-induced neuroinflammation Journal of Anesthesia and Peri-Operative Medicine 1 (2): 120-124,2014.
Laudanski K, Qing M, Zawadka M, Oszkiel H, Lapko N, Nowak Z, Worthen SG: Ketamine affects the differentiation of monocytes into immature dendritic cells via Transforming Growth Factor Anesthesiology 123 (3): 628-641,2015.
Joseph T, DiMeglio M, Huffenberger, Laudanski K: Electrolyte Repletion in Intensive Care Units Anesthesia & Analgesia 124 (4): 2018.
Laudanski K, Valagapudi V: ICU Capacity Strain: The need for standardization of definitions Critical Care Connection : 14,2018.
Pieczynski LM, Laudanski K, Speck RM, McCunn M: Analysis of field reports from anaesthesia volunteers in low- to middle-income countries. Medical Education 47 (10): 1029-1036,2013.
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