Description of Research Expertise:
My research focuses on the three distinctive area: regulation of DNA expression in survivors after critical care illnesses, health care operation and medical decision-making processes and medical volunteerism. On the first subject, I am PI on the NIH funded project focusing on the long-term regulation of several genes expression after critical care event and their impact on the recovery of the patient after critical care illness and anesthesia/surgery. I am very interested in the medical decision-making process and health care operation as the primary determinant of patient recovery. I study the cognitive process, biases and the effect of emotional imprints on the decisions made by medical professionals. My prior work showed that numerous number of time the delivery of health services is superfluous and exposed the patient to unnecessary risk. Hospital system suffers negative economic consequences because of the suboptimal decision-making processes. Understanding and education about these processes are pivotal in the next healthcare system. Optimizing healthcare in the ICU is another area of interest. ICU environment is demanding with significant swings in demand. Developing improvements in the existing healthcare models, or envisioning the new healthcare models may have a potentially significant impact on individual and population health. Tele-ICU is my particular interest especially I the area of integration with wearables device and alternative models of healthcare delivery. Simulation is frequently utilized by me due to its versatility in discovering operating problems and providing the staff with unique experience. Adjusting the healthcare operation based on the availability, cultural specificity, and local demands is my passion I frequently pursue in the austere and remote settings.
Laudanski K, Zawadka M, Polosak J, Modi J, DiMeglio M, Gutsche J, Szeto WY, Puzianowska-Kuzmicka M: Acquired immunological imbalance after surgery with cardiopulmonary bypass due to to epigenetic over-activation of PU.1/M-CSF Journal of Translational Medicine 143 (16): 1-13,2018.
Laudanski K, Lapko N, Zawadka M, Danet-Desnoyer G, Worthen GS: The clinical and immunological performance of 28 days survival model of cecal ligation and puncture in humanized mice PLoS One 12 (7): e0180377,2017.
Lapko N, Zawadka M, Polosak J, Worthen GS, Danet-Desnoyers G, Puzianowska-Kuzmicka M, Laudanski K: Long-term monocyte dysfunction after sepsis in humanized mice is related to persisted activation of M-CSF and demethylation of PU.1 and it can be reversed by blocking M-CSF in vitro or by transplanting naïve autologous stem cells in vivo Frontiers in Immunology 8 : 401-412,2017.
Zawadka M, Wahome J, Oszkiel H, Szeto WY, Cobb B, Laudanski K: Long-term alterations in monocyte function after elective cardiac surgery Anaesthesia 72 (7): 879-888,2017.
Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG: Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways Proceedings of the National Academy of Sciences of the United States of America 103 (42): 15564-15569,2006.
Laudanski K, Eckenhoff R: Anesthesia-induced neuroinflammation Journal of Anesthesia and Peri-Operative Medicine 1 (2): 120-124,2014.
Laudanski K, Qing M, Zawadka M, Oszkiel H, Lapko N, Nowak Z, Worthen SG: Ketamine affects the differentiation of monocytes into immature dendritic cells via Transforming Growth Factor Anesthesiology 123 (3): 628-641,2015.
Joseph T, DiMeglio M, Huffenberger, Laudanski K: Electrolyte Repletion in Intensive Care Units Anesthesia & Analgesia 124 (4): 2018.
Laudanski K, Valagapudi V: ICU Capacity Strain: The need for standardization of definitions Critical Care Connection : 14,2018.
Pieczynski LM, Laudanski K, Speck RM, McCunn M: Analysis of field reports from anaesthesia volunteers in low- to middle-income countries. Medical Education 47 (10): 1029-1036,2013.
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