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Kristy L. Weber, MD

Kristy L. Weber, MD Physician

Chief, Orthopaedic Oncology Director of the Sarcoma Program, Abramson Cancer Center Vice-Chair of Faculty Affairs, Department of Orthopaedic Surgery Instructor A of Medicine

Dr. Weber is employed by Penn Medicine.

About Dr. Kristy L. Weber

Dr. Weber currently serves as Chief of Orthopaedic Oncology at Penn Medicine and Director of the Sarcoma Program in the Abramson Cancer Center. She specializes in the treatment of children and adults with benign and malignant bone and soft tissue tumors as well as metastatic bone disease. Limb salvage surgery around the shoulder, hip, knee and pelvis is a particular interest. Dr. Weber has built a collaborative sarcoma research team combining clinical and basic research between Penn Medicine and Children's Hospital of Philadelphia. 

She was elected to the Penn Academy of Master Clinicians in 2017. Dr. Weber currently serves as  President of the American Academy of Orthopaedic Surgeons (AAOS) and is the Academy’s first woman president.

Recognized by America's Top Doctors, 2015 - 2018

Recognized by Best Doctors in America 2015 - 2018

Recognized in Philadelphia magazine's annual Top Docs issues for 2018 and 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Orthopaedic Surgery

Programs & Centers:

Board Certification:

  • Orthopaedic Surgery, 2000

Clinical Expertise:

  • Adamantinoma
  • Alveolar Soft Part Sarcoma
  • Amputation of Leg
  • Angiosarcoma
  • Benign Neoplasm Bone
  • Benign Neoplasm of Skin
  • Biopsy
  • Bone Allograft
  • Bone Autograft
  • Bone Cancer Surgery
  • Bone Cyst
  • Bone Mass
  • Bone Sarcoma
  • Bone Tumors
  • Brown Tumor
  • Chondroma
  • Chondrosarcoma
  • Chordoma
  • Clear Cell Sarcoma
  • CT Scan Guided Biopsy
  • Dedifferentiated Liposarcoma
  • Epithelioid Sarcoma
  • Ewings Sarcoma
  • Extraskeletal Osteosarcoma
  • Fibrosarcoma
  • Fibrous Dysplasia
  • Giant Cell Tumor of Soft Tissue
  • Giant Cell Tumor of the Bone
  • Leiomyosarcoma
  • Limb Salvage Surgery
  • Liposarcoma
  • Low Grade Fibromyxoid Sarcoma
  • Malignant Fibrous Histiocytoma
  • Multiple Myeloma
  • Myxofibrosarcoma
  • Myxoid Liposarcoma
  • Osteochondroma
  • Osteoid Osteoma
  • Osteosarcoma
  • Pathological Fracture
  • Pleomorphic Liposarcoma
  • Rhabdomyosarcoma
  • Sarcoma
  • Skeletal Metastasis
  • Skeletal Reconstruction
  • Synovial Chondromatosis
  • Synovial Sarcoma
  • Undifferentiated Pleomorphic Sarcoma
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Johns Hopkins University School of Medicine
Residency: University of Iowa Hospitals and Clinics
Fellowship: Mayo Clinic


American Academy of Orthopaedic Surgeons, National American Board of Orthopaedic Surgery (ABOS), National American College of Radiology, National American Orthopaedic Association, National American Society for Bone and Mineral Research (ASBMR), National Connective Tissue Oncology Society, International International Society of Limb Salvage, International Maryland Orthopaedic Association, Local Musculoskeletal Tumor Society, National Orthopaedic Research and Education Foundation (OREF), National Orthopaedic Research Society, National Ruth Jackson Orthopaedic Society, National Twentieth Century Orthopaedic Association, National University of Iowa Department of Orthopaedics Second Century Committee, National

Hospital Affiliation

Dr. Weber is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Specializes in murine models of bone metastasis from breast and kidney.

Additional expertise in osteosarcoma murine models studying local tumor growth in bone and metastasis to the lungs.

Focused on identifying unique molecular targets in both breast and renal cancer.

Utilizes novel drug therapies to treat bone destruction and systemic metastasis in breast and renal cancer murine models.

Selected Publications:

Weber K: Part 4 of a series of interviews with Janet S. Wright, MD, Senior VP of Science and Quality at the American College of Cardiology on Quality Initiatives AAOS Now Podcast : 2014.

Davalos-Bichara M, Lin FR, Carey JP, Walston JD, Fairman JE, Schubert MC, Barron JS, Hughes J, Millar JL, Spar A, Weber KL, Ying HS, Zackowski KM, Zee D, Agrawal Y: Development and Validation of a Falls-Grading Scale. Journal of Geriatric Physical Therapy 36 (2): 63-67,2013.

Weber, KL: Musculoskeletal Oncology and Systemic Disease AAOS Comprehensive Orthopaedic Review : 2013.

Lau WM, Doucet M, Stadel R, Huang D, Weber KL, Kominsky SL: ENPP1: A Potential Facilitator of Breast Cancer Bone Metastasis PLoS One : 2013.

Del Grande F, Subhawong T, Weber KL, Fayad L: Detection of Soft Tissue Sarcoma Recurrence: Added Value of Functional MR Imaging Techniques at 3T Radiology : 2013.

Mugera C, Belzberg A, Suh KJ, Weber KL, Carrino J, Huisman T, Chabbra A: Sclerotic Lesions of the Spine - MRI Assessment Journal of Magnetic Resonance Imaging : 2013.

Lau WM, Doucet M, Huang D, Weber KL, Kominsky SL: CITED2 Modulates Estrogen Receptor Transcriptional Activity in Breast Cancer Cells Biochemical and Biophysical Research Communications : 2013.

Weber KL and Kominsky: Concepts and Surgical Treatment of Metastatic Bone Disease. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, (8th ed) : 2013.

Miclau T, Moshed S, Weber KL (Section 1 Editors): Principles of Orthopaedics (Section 1) AAOS Orthopaedic Knowledge Update 11 : 2013.

Turkelson C and Weber KL: The Scientific Foundations of Healthcare Guidelines In Orthopaedic Basic Science: Foundations of Clinical Practice, ed 4. : 2013.

Academic Contact Info

Hospital of the University of Pennsylvania, 3400 Spruce Street, 2 Silverstein
Philadelphia, PA 19104
Phone: (215) 349-8200
Patient appointments: 800-789-7366

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