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Kirk J. Wangensteen, MD, PhD

Kirk J. Wangensteen, MD, PhD Physician

Assistant Professor of Medicine in Genetics Assistant Professor of Medicine

Dr. Wangensteen is employed by Penn Medicine.

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Clinical Specialties


  • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 2016
  • Internal Medicine, 2015

Clinical Expertise:

  • Cancer Risk Evaluation
  • Familial Adenomatous Polyposis (FAP)
  • Gastrointestinal Cancer
  • Gastrointestinal Cancer Genetics
  • Hereditary Diffuse Gastric Cancer (HDGC)
  • Lynch Syndrome
  • MUTYH-Associated Polyposis (MAP)
  • Peutz-Jeghers Syndrome (PJS)
  • Polyposis Syndromes

Description of Clinical Expertise

Kirk Wangensteen, MD/PhD specializes in Gastroenterology and Hepatology and his clinical expertise includes genetic diseases of the gastrointestinal tract, pancreas, and liver.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Minnesota Medical School
Residency: University of Vermont Medical Center
Fellowship: Hospital of the University of Pennsylvania


American Association for the Advancement of Science, International American Association for the Study of Liver Diseases, National American Gastroenterological Association, National Doctors Without Borders, International International Liver Cancer Association, International

Hospital Affiliation

Dr. Wangensteen is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Kirk Wangensteen, MD/PhD's research expertise includes liver biology and genetics. In particular, he is mapping the genetic pathways that enable liver regeneration and cause liver cancer. He has set up innovative in vivo screening systems to elucidate these pathways in a mouse model of liver injury and repopulation.

Selected Publications:

Wangensteen Kirk J, Wang Yue J, Dou Zhixun, Wang Amber W, Mosleh-Shirazi Elham, Horlbeck Max A, Gilbert Luke A, Weissman Jonathan S, Berger Shelley L, Kaestner Klaus H: Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology (Baltimore, Md.) 68 (2): 663-676,2018.

Wang Amber W*, Wangensteen Kirk J*, Wang Yue J, Zahm Adam M, Moss Nicholas G, Erez Noam, Kaestner Klaus H: TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury. The Journal of clinical investigation 128 (6): 2297-2309,2018.

Wang Chao, Chen Wen-Jian, Wu Ying-Fu, You Pu, Zheng Shang-Yong, Liu Chang-Cheng, Xiang Dao, Wang Min-Jun, Cai Yong-Chao, Zhao Qing-Hui, Borjigin Uyunbilig, Liu Wei, Xiong Wu-Jun, Wangensteen Kirk J, Wang Xin, Liu Zhong-Min, He Zhi-Ying: The extent of liver injury determines hepatocyte fate toward senescence or cancer. Cell death & disease 9 (5): 575,2018.

Shoshkes-Carmel Michal, Wang Yue J, Wangensteen Kirk J, Tóth Beáta, Kondo Ayano, Massassa Efi E, Itzkovitz Shalev, Kaestner Klaus H: Subepithelial telocytes are an important source of Wnts that supports intestinal crypts. Nature 557 (7704): 242-246,2018.

Mahmud Nadim, Wangensteen Kirk J: Endoscopic Band Ligation to Treat a Massive Hemorrhoidal Hemorrhage Following a Transrectal Ultrasound-Guided Prostate Biopsy. Annals of coloproctology 34 (1): 47-51,2018.

Wang Min-Jun, Chen Fei, Liu Qing-Gui, Liu Chang-Cheng, Yao Hao, Yu Bing, Zhang Hai-Bin, Yan He-Xin, Ye Yibiao, Chen Tao, Wangensteen Kirk J, Wang Xin, Hu Yi-Ping, He Zhi-Ying: Insulin-like growth factor 2 is a key mitogen driving liver repopulation in mice. Cell death & disease 9 (2): 26,2018.

Kieckhaefer, Julia, Maina, Flavio, Wells, Rebecca, Wangensteen, Kirk: Liver cancer gene discovery using gene targeting, Sleeping Beauty, and CRISPR/Cas9 Seminars in Liver Disease : 2018.

Adam M. Zahm, Amber W. Wang, Yue J. Wang, Jonathan Schug, Kirk J. Wangensteen, * and Klaus H. Kaestner*: A high-throughput pairwise microRNA inhibition screen in the regenerating mouse liver FASEB Liver Biology Conference : 2018.

Kirk J. Wangensteen, Adam M. Zahm, and Klaus H. Kaestne: Novel combination therapy for hepatocellular carcinoma identified by genetic screening FASEB Liver Biology Meeting : 2018.

Dou Zhixun, Ghosh Kanad, Vizioli Maria Grazia, Zhu Jiajun, Sen Payel, Wangensteen Kirk J, Simithy Johayra, Lan Yemin, Lin Yanping, Zhou Zhuo, Capell Brian C, Xu Caiyue, Xu Mingang, Kieckhaefer Julia E, Jiang Tianying, Shoshkes-Carmel Michal, Tanim K M Ahasan Al, Barber Glen N, Seykora John T, Millar Sarah E, Kaestner Klaus H, Garcia Benjamin A, Adams Peter D, Berger Shelley L: Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature 550 (7676): 402-406,2017.

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Academic Contact Info

Division of Gastroenterology
421 Curie Boulevard, BRB 910

Philadelphia, PA 19104
Phone: (215) 573-7314
Patient appointments: 800-789-7366 (PENN)