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Kirk J. Wangensteen, MD, PhD

Kirk J. Wangensteen, MD, PhD Physician

Associate Professor of Pediatrics at the Children's Hospital of Philadelphia

Dr. Wangensteen is employed by Penn Medicine.

Clinical Specialties


  • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 2016
  • Internal Medicine, 2015

Clinical Expertise:

  • Abdominal Bloating
  • Abdominal Disorders
  • Abdominal Distention
  • Abdominal Pain
  • Abnormal Liver Function
  • Abnormal Stool
  • Acute Pancreatitis
  • Alcoholic Liver Disease
  • Altered Bowel Habits
  • Anal Pain
  • Anal Spasm
  • Annular Pancreas
  • Anorexia
  • Autoimmune Enteropathy
  • Autoimmune Hepatitis
  • Barrett's Esophagus
  • Benign Neoplasm of Colon
  • Blood in Stool
  • Bowel Disorders
  • Bowel Dysmotility
  • Bowel incontinence (Fecal Incontinence)
  • Bright Red Blood in Rectum
  • C. Difficile (Clostridium Difficile Diarrhea)
  • Celiac Disease (Celiac Sprue)
  • Cholangitis
  • Cholecystitis
  • Cholelithiasis
  • Cholestasis
  • Chronic Diarrhea
  • Chronic Pancreatitis
  • Colitis
  • Collagenous Colitis
  • Colonic Inertia
  • Colonic Polyps
  • Colonoscopy
  • Constipation
  • Crigler Najjar Syndrome
  • Crohn's Disease
  • Cyclic Vomiting Syndrome
  • Difficulty Swallowing (Dysphagia)
  • Digestive Conditions
  • Diverticular Disease
  • Diverticulitis (Colonic Diverticulitis)
  • Duodenal Ulcer
  • Duodenitis
  • Dyspepsia
  • Early Satiety
  • Eosinophilic Colitis
  • Eosinophilic Enteritis
  • Eosinophilic Esophagitis (EoE)
  • Eosinophilic Gastritis
  • Epigastric Pain
  • Eructation
  • Esophageal Achalasia
  • Esophageal Disorders
  • Esophageal Motility Disorders
  • Esophageal Spasm
  • Esophageal Stricture
  • Esophageal Thickening
  • Esophageal Ulcer
  • Esophageal Varices
  • Esophagitis
  • Esophagus Tumors
  • Fatty Liver Diseases
  • Fecal Impaction
  • Feeding Tube Management
  • Flatulence
  • Focal Nodular Hyperplasia
  • Gallbladder Disorders
  • Gallbladder Polyp
  • Gastric Anomaly
  • Gastric Ulcer
  • Gastritis
  • Gastroenteritis
  • Gastroesophageal Reflux Disease (GERD)
  • Gastrointestinal Amyloid
  • Gastrointestinal Bleeding
  • Gastrointestinal Cancer Screening
  • Gastrojejunal Ulcer
  • Gastroparesis
  • Gastroscopy
  • Giardiasis
  • Gluten Sensitivity
  • H. Pylori Infection
  • Hematemesis
  • Hemochromatosis
  • Hepatitis
  • Hepatitis B
  • Hepatitis C
  • Hepatomegaly
  • Hereditary Nonpolyposis Colorectal Cancer
  • Hiatal Hernia
  • Ileitis
  • Inflammatory Bowel Disease (IBD)
  • Intestinal Obstruction
  • Intestinal Pseudo-Obstruction
  • Intractable Vomiting
  • Irritable Bowel Syndrome
  • Ischemic Colitis
  • Jaundice
  • Lactose Intolerance
  • Liver Cirrhosis
  • Liver Diseases
  • Liver Mass
  • Lymphocytic Colitis
  • Malabsorption
  • Melena
  • Microscopic Colitis
  • Motility Disorders
  • Nausea
  • Non-Alcoholic Fatty Liver Disease
  • Obstipation
  • Obstructive Jaundice
  • Odynophagia
  • Pancreas Divisum
  • Pancreatic Cyst
  • Pancreatic Insufficiency
  • Pancreatic Pseudocyst
  • Pancreaticobiliary Disease
  • Pancreatitis
  • Peptic Ulcer Disease (Stomach Ulcers)
  • Peritonitis
  • Pernicious Anemia
  • Peutz-Jeghers Syndrome
  • Polyposis Syndrome
  • Portal Hypertension
  • Portal Hypertensive Gastropathy
  • Postprandial Diarrhea
  • Proctitis
  • Proctosigmoidoscopy
  • Rectal Bleeding
  • Rectal Disorders
  • Short Bowel Syndrome (Short Gut Syndrome)
  • Sigmoidoscopy
  • Small Bowel Disease
  • Steatorrhea
  • Stomach Cramps
  • Stomach Disorders
  • Swallowing Disorders
  • Toxic Liver Injury
  • Ulcerative Colitis
  • Upper GI Endoscopy
  • Vomiting
  • Whipple's Disease
  • Wilson's Disease
  • Zenker's Diverticulum
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Minnesota Medical School
Residency: University of Vermont Medical Center
Fellowship: Hospital of the University of Pennsylvania


American Association for the Advancement of Science, International American Association for the Study of Liver Diseases, National American Gastroenterological Association, National Cancer Prevention and Research Institute of Texas (CPRIT) Study Section, National Doctors Without Borders, International International Liver Cancer Association, International

Hospital Affiliation

Dr. Wangensteen is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Kirk Wangensteen, MD/PhD's research expertise includes liver biology and genetics. In particular, he is mapping the genetic pathways that enable liver regeneration and cause liver cancer. He has set up innovative in vivo screening systems to elucidate these pathways in a mouse model of liver injury and repopulation.

Selected Publications:

Wang Amber W, Wang Yue J, Zahm Adam M, Morgan Ashleigh R, Wangensteen Kirk J, Kaestner Klaus H: The Dynamic Chromatin Architecture of the Regenerating Liver. Cellular and molecular gastroenterology and hepatology : 2019.

Wang Amber W, Zahm Adam M, Wangensteen Kirk J: Cell Type-specific Gene Expression Profiling in the Mouse Liver. Journal of visualized experiments : JoVE (151): 2019.

Mahmud Nadim, Wangensteen Kirk J: Colocolic intussusception. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology : 2019.

Kieckhaefer Julia E, Maina Flavio, Wells Rebecca G, Wangensteen Kirk J: Liver Cancer Gene Discovery Using Gene Targeting, Sleeping Beauty, and CRISPR/Cas9. Seminars in liver disease 39 (2): 261-274,2019.

Preziosi Morgan E, Zahm Adam M, Vázquez-Salgado Alexandra M, Ackerman Daniel, Gade Terence P, Kaestner Klaus H, Wangensteen Kirk J: LXR agonism potentiates Sorafenib activity in HCC by inducing metabolic stress Hepatology : 2019.

Preziosi, Morgan E., Zahm, Adam M., Kaestner, Klaus H., Wangensteen, Kirk J.: LXR agonism and Sorafenib treatment as novel combination therapy for hepatocellular carcinoma The FASEB Journal 33 (1_supplement): 126.9-126.9,2019.

Wangensteen Kirk J, Wang Yue J, Dou Zhixun, Wang Amber W, Mosleh-Shirazi Elham, Horlbeck Max A, Gilbert Luke A, Weissman Jonathan S, Berger Shelley L, Kaestner Klaus H: Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology (Baltimore, Md.) 68 (2): 663-676,2018.

Wang Amber W*, Wangensteen Kirk J*, Wang Yue J, Zahm Adam M, Moss Nicholas G, Erez Noam, Kaestner Klaus H: TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury. The Journal of clinical investigation 128 (6): 2297-2309,2018.

Wang Chao, Chen Wen-Jian, Wu Ying-Fu, You Pu, Zheng Shang-Yong, Liu Chang-Cheng, Xiang Dao, Wang Min-Jun, Cai Yong-Chao, Zhao Qing-Hui, Borjigin Uyunbilig, Liu Wei, Xiong Wu-Jun, Wangensteen Kirk J, Wang Xin, Liu Zhong-Min, He Zhi-Ying: The extent of liver injury determines hepatocyte fate toward senescence or cancer. Cell death & disease 9 (5): 575,2018.

Shoshkes-Carmel Michal, Wang Yue J, Wangensteen Kirk J, Tóth Beáta, Kondo Ayano, Massassa Efi E, Itzkovitz Shalev, Kaestner Klaus H: Subepithelial telocytes are an important source of Wnts that supports intestinal crypts. Nature 557 (7704): 242-246,2018.

View all publications

Academic Contact Info

Division of Gastroenterology
421 Curie Boulevard, BRB 910

Philadelphia, PA 19104
Phone: (215) 573-7314
Patient appointments: 800-789-7366