Description of Research Expertise:
1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.
2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.
3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.
Berger Ian, Cengel Keith A, Simone Charles B, Alley Evan W, Roshkovan Leonid, Haas Andrew R, Patel Akash M, Khalid Urooj, Culligan Melissa J, McNulty Sally, Singhal Sunil, Friedberg Joseph S, Katz Sharyn I: Lymphangitic carcinomatosis: A common radiographic manifestation of local failure following extended pleurectomy/decortication in patients with malignant pleural mesothelioma. Lung cancer (Amsterdam, Netherlands) 132 : 94-98,2019.
Kim Michele, Irmen Peyton, Shoniyozov Khayrullo, Verginadis Ioannis I, Cengel Keith A, Koumenis Costas, Metz James M, Dong Lei, Diffenderfer Eric: Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research. Physics in medicine and biology : 2019.
Luna José Marcio, Chao Hann-Hsiang, Diffenderfer Eric S, Valdes Gilmer, Chinniah Chidambaram, Ma Grace, Cengel Keith A, Solberg Timothy D, Berman Abigail T, Simone Charles B: Predicting radiation pneumonitis in locally advanced stage II-III non-small cell lung cancer using machine learning. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 133 : 106-112,2019.
Cramer Gwendolyn, Shin Michael, Hagan Sarah, Katz Sharyn I, Simone Charles B, Busch Theresa M, Cengel Keith A: Modeling Epidermal Growth Factor Inhibitor-mediated Enhancement of Photodynamic Therapy Efficacy Using 3D Mesothelioma Cell Culture. Photochemistry and photobiology 95 (1): 397-405,2019.
Predina Jarrod D, Newton Andrew D, Corbett Christopher, Xia Leilei, Shin Michael, Sulfyok Lydia Frenzel, Okusanya Olugbenga T, Cengel Keith A, Haas Andrew, Litzky Leslie, Kucharczuk John C, Singhal Sunil: A Clinical Trial of TumorGlow to Identify Residual Disease During Pleurectomy and Decortication. The Annals of thoracic surgery 107 (1): 224-232,2019.
Schonewolf Caitlin A, Heskel Marina, Doucette Abigail, Singhal Sunil, Frick Melissa A, Xanthopoulos Eric P, Corradetti Michael N, Friedberg Joseph S, Pechet Taine T, Christodouleas John P, Levin William, Berman Abigail, Cengel Keith A, Verma Vivek, Hahn Stephen M, Kucharczuk John C, Rengan Ramesh, Simone Charles B: Five-year Long-term Outcomes of Stereotactic Body Radiation Therapy for Operable Versus Medically Inoperable Stage I Non-small-cell Lung Cancer: Analysis by Operability, Fractionation Regimen, Tumor Size, and Tumor Location. Clinical lung cancer 20 (1): e63-e71,2019.
Davis Richard W, Snyder Emma, Miller Joann, Carter Shirron, Houser Cassandra, Klampatsa Astero, Albelda Steven M, Cengel Keith A, Busch Theresa M: Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy. Photochemistry and photobiology 95 (1): 430-438,2019.
Rice Stephanie R, Li Yun R, Busch Theresa M, Kim Michele M, McNulty Sally, Dimofte Andrea, Zhu Timothy C, Cengel Keith A, Simone Charles B: A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma. Photochemistry and photobiology 95 (1): 411-418,2019.
Barsky Andrew R, Cengel Keith A, Katz Sharyn I, Sterman Daniel H, Simone Charles B: First-ever Abscopal Effect after Palliative Radiotherapy and Immuno-gene Therapy for Malignant Pleural Mesothelioma. Cureus 11 (2): e4102,2019.
Frick Melissa A, Kao Gary D, Aguarin Louise, Chinniah Chimbu, Swisher-McClure Samuel, Berman Abigail T, Levin William P, Cengel Keith A, DeCesaris Cristina, Hahn Stephen M, Dorsey Jay F, Simone Charles B: Circulating Tumor Cell Assessment in Presumed Early Stage Non-Small Cell Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy: A Prospective Pilot Study. International journal of radiation oncology, biology, physics 102 (3): 536-542,2018.
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