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Juan M. Ortega-Legaspi, MD, PhD

Juan M. Ortega-Legaspi, MD, PhD Physician

Instructor A of Medicine

Languages spoken:

  • French
  • Spanish

Dr. Ortega-Legaspi is employed by Penn Medicine.

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Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 2016
  • Internal Medicine, 2013

Clinical Expertise:

  • Acute Decompensated Heart Failure
  • Alcoholic Cardiomyopathy
  • Arrhythmogenic Right Ventricular Dysplasia
  • Arterial Insufficiency
  • Beriberi
  • Cardiac Amyloid
  • Cardiac Sarcoidosis
  • CardioMEMS
  • Cardiomyopathy
  • Chronic Inotropic Therapy
  • Circulatory Assist Devices
  • Congenital Heart Disease in Adult
  • Congestive Heart Failure
  • Cor Pulmonale
  • Diabetic Cardiomyopathy
  • Dilated Cardiomyopathy
  • Familial Cardiomyopathy
  • Genetic Cardiomyopathy
  • Giant Cell Myocarditis
  • Heart Biopsy
  • Home Inotropes
  • Hypertrophic Cardiomyopathy
  • Idiopathic Hypertrophic Subaortic Stenosis
  • Infiltrative Disorders of the Heart
  • Left Heart Failure
  • Left Ventricular Assist Device
  • Mechanical Circulatory Support
  • Myocarditis
  • Pulmonary Edema
  • Restrictive Cardiomyopathy
  • Rheumatic Heart Disease
  • Rheumatic Heart Failure
  • Right Heart Failure
  • Right Ventricular Cardiomyopathy
  • Tachycardia-Induced Cardiomyopathy
  • Takatsubo Cardiomyopathy
  • Ventricular Aneurysm
  • Viral Cardiomyopathy
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Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • OPR Medicare
  • OPR New Jersey Medicaid
  • OPR Pennsylvania Medicaid
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Universidad Nacional Autonoma de Mexico
Residency: Emory University
Fellowship: University of Washington Hospital and Clinics
Fellowship: Hospital of the University of Pennsylvania


American College of Cardiology, National

Hospital Affiliation

Dr. Ortega-Legaspi is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Selected Publications:

Rame JE, Ortega-Legaspi JM, Cappola A, Dumon KR, Cappola TP: Leptin Modifies the Impact of BMI on Heart Failure Progression: The Obesity Paradox Unraveling. International Society for Heart and Lung Transplantation 38th Annual Meeting and Scientific Sessions. Nice, France : 2018.

Ortega-Legaspi JM, Chyu J, Zhang Y, El-Nachef D, Oyama K, Gornalusse GG, Russell DW, MacLellan WR: Major Histocompatibility Complex-I Deficient Embryonic Stem Cell Derived Cardiomyocytes as Potential off-the-Shelf Therapy for Cardiac Regeneration. International Society for Stem Cell Research. Boston, MA : 2017.

Tan MCC, Ortega-Legaspi JM, Cheng SF, Patton KK: Acute myocarditis following high-dose interleukin-2 treatment. J Cardiol Cases 15 (1): 28–31,2016.

Ortega-Legaspi JM, Airhart S, Nguyen H, Masri SC, Mokadam NA, Mahr C, Kirkpatrick JN: Echocardiographic Findings in Continuous-Flow Left Ventricular Assist Device Pump Thrombosis. Heart Failure Society of America 20th Annual Scientific Meeting, Orlando, Fl : 2016.

Ortega-Legaspi JM, Chyiu J, de la Mata A, MacLellan WR: Major Histocompatibility Complex-I Deficient Embryonic Stem Cell-Derived Cardiomyocytes as Potential Off The-Shelf Therapy For Cardiac Regeneration. World Congress of Cardiology and Cardiovascular Health. World Heart Federation. Mexico City : 2016.

Landázuri N, Levit RD, Joseph G, Ortega-Legaspi JM, Flores CA, Weiss D, Sambanis A, Weber CJ, Safley SA, Taylor WR: Alginate microencapsulation of human mesenchymal stem cells as a strategy to enhance paracrine-mediated vascular recovery after hind limb ischemia. J Tissue Eng Regen Med 10 (3): 222-32,2016.

Hayek SS, Abdou MH, Demoss BD, Ortega-Legaspi JM, Veledar E, Deka A, Krishnan SK, Wilmot KA, Patel AD, Kumar VR, Devireddy CM: Prevalence of resistant hypertension and eligibility for catheter-based renal denervation in hypertensive outpatients. Am J Hypertens 26 (12): 1452-8,2013.

Ortega-Legaspi JM, de Gortari P, Garduño-Gutiérrez R, Amaya MI, León-Olea M, Coffeen U, Pellicer F: Expression of the dopaminergic D1 and D2 receptors in the anterior cingulate cortex in a model of neuropathic pain. Mol Pain 7 : 97,2011.

Coffeen U, Ortega-Legaspi JM, López-Muñoz FJ, Simón-Arceo K, Jaimes O, Pellicer F: Insular Cortex Lesion Diminishes Neuropathic and Inflammatory Pain-Like Behaviours. Eur J Pain 15 (2): 132-8,2011.

Coffeen U, Ortega-Legaspi JM, de Gortari P, Simón-Arceo K, Jaimes O, Amaya MI, Pellicer F: Inflammatory nociception diminishes dopamine release and increases dopamine D2 receptor mRNA in the rat's insular cortex. Mol Pain 6 : 75,2010.

Academic Contact Info

11th Floor South Perelman
34th Civic Center Blvd.

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)