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John Q. Trojanowski, MD, PhD

John Q. Trojanowski, MD, PhD Physician

Director of the Institute on Aging Director, Medical Pathology William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology

Languages spoken:

  • German

Dr. Trojanowski is employed by Penn Medicine.

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There is no publicly available rating for this medical professional for one of the following reasons:

  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
  3. He or she sees patients but has not yet received the minimum 30 patient satisfaction reviews in the past 12 months, ensuring that the rating is statistically reliable and a true reflection of patient satisfaction.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1981
  • Pathology - Neuropathology, 1981

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Homestead Smart Health Plans
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Tufts University School of Medicine
Residency: Mount Auburn Hospital
Residency: Massachusetts General Hospital
Residency: Hospital of the University of Pennsylvania


Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, National Alzheimer's Association, Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, International American Academy of Neurology (Consultant, Potamkin Award Subcommittee), American Academy of Neurology (Consultant, Potamkin Award), American Academy of Neurology, American Association of Neuropathologists, American Association of Pathologists, American Board of Pathology, American Brain Tumor Association, American Federation for Aging Research National Scientific Advisory Council, American Health Assistance Foundation Alzheimer's Disease Research Review Committee, American Society for Cell Biology, American Society for Clinical Investigators, American Society for Investigative Pathology, Amyotrophic Lateral Sclerosis Association Grant Review Committee, Association of American Physicians, Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, National Dystonia Medical Research Foundation, Elwyn Institute, Elwyn, PA, EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), National Harvard Brain Tissue Resource Center, Institute of Medicine Class of 2002, Institute on Aging, International Academy of Pathology, Abstract Review Board member, Killam Research Fellowship Program, The Canada Council, MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, National National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, National National Campaign to End Neurological Disorders (END)), National Cancer Institute, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, Board of Scientific Councilors, National Institute on Aging, National Advisory Council on Aging (NACA), National Institutes of Child Health and Human Development, National Institutes of Health Grant Study Section Reviewers Reserve, National Institutes of Health Neurology A Study Section, National Institutes of Health Pathology A Study Section, National Institutes of Health, National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, National Institutes of Neurologic Disorders and Stroke, National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, National Sleep Foundation, National Sleep Foundation, Neuroscience Interest Group of the Institute of Medicine, National Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, National NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, National Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, Society for Neuroscience, Society for Neuroscience, The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, National The Institute for the Study of Aging, University of Pittsburgh Alzheimer’s Disease Research Center, University of Washington Alzheimer's Disease Research Center,

Hospital Affiliation

Dr. Trojanowski is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications:

Portelius Erik, Olsson Bob, Höglund Kina, Cullen Nicholas C, Kvartsberg Hlin, Andreasson Ulf, Zetterberg Henrik, Sandelius Åsa, Shaw Leslie M, Lee Virginia M Y, Irwin David J, Grossman Murray, Weintraub Daniel, Chen-Plotkin Alice, Wolk David A, McCluskey Leo, Elman Lauren, McBride Jennifer, Toledo Jon B, Trojanowski John Q, Blennow Kaj: Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta neuropathologica 136 (3): 363-376,2018.

Martini-Stoica Heidi, Cole Allysa L, Swartzlander Daniel B, Chen Fading, Wan Ying-Wooi, Bajaj Lakshya, Bader David A, Lee Virginia M Y, Trojanowski John Q, Liu Zhandong, Sardiello Marco, Zheng Hui: TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of experimental medicine : 2018.

Shi Min, Tang Lu, Toledo Jon B, Ginghina Carmen, Wang Hua, Aro Patrick, Jensen Poul H, Weintraub Daniel, Chen-Plotkin Alice S, Irwin David J, Grossman Murray, McCluskey Leo, Elman Lauren B, Wolk David A, Lee Edward B, Shaw Leslie M, Trojanowski John Q, Zhang Jing: Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association 14 (8): 1052-1062,2018.

Schmitz Matthias, Villar-Piqué Anna, Llorens Franc, Gmitterová Karin, Hermann Peter, Varges Daniela, Zafar Saima, Lingor Paul, Vanderstichele Hugo, Demeyer Leentje, Stoops Erik, Trojanowski John Q, Lee Virginia M-Y, Zerr Inga: Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy. Molecular neurobiology : 2018.

McMillan Corey T, Lee Edward B, Jefferson-George Kyra, Naj Adam, Van Deerlin Vivianna M, Trojanowski John Q, Wolk David A: Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance? Annals of clinical and translational neurology 5 (8): 927-934,2018.

Alosco Michael L, Tripodis Yorghos, Fritts Nathan G, Heslegrave Amanda, Baugh Christine M, Conneely Shannon, Mariani Megan, Martin Brett M, Frank Samuel, Mez Jesse, Stein Thor D, Cantu Robert C, McKee Ann C, Shaw Leslie M, Trojanowski John Q, Blennow Kaj, Zetterberg Henrik, Stern Robert A: Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association : 2018.

Nativio Raffaella, Donahue Greg, Berson Amit, Lan Yemin, Amlie-Wolf Alexandre, Tuzer Ferit, Toledo Jon B, Gosai Sager J, Gregory Brian D, Torres Claudio, Trojanowski John Q, Wang Li-San, Johnson F Brad, Bonini Nancy M, Berger Shelley L: Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease. Nature neuroscience 21 (7): 1018,2018.

Oukoloff Killian, Kovalevich Jane, Cornec Anne-Sophie, Yao Yuemang, Owyang Zachary A, James Michael, Trojanowski John Q, Lee Virginia M-Y, Smith Amos B, Brunden Kurt R, Ballatore Carlo: Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines. Bioorganic & medicinal chemistry letters 28 (12): 2180-2183,2018.

Robinson John L, Lee Edward B, Xie Sharon X, Rennert Lior, Suh EunRan, Bredenberg Colin, Caswell Carrie, Van Deerlin Vivianna M, Yan Ning, Yousef Ahmed, Hurtig Howard I, Siderowf Andrew, Grossman Murray, McMillan Corey T, Miller Bruce, Duda John E, Irwin David J, Wolk David, Elman Lauren, McCluskey Leo, Chen-Plotkin Alice, Weintraub Daniel, Arnold Steven E, Brettschneider Johannes, Lee Virginia M-Y, Trojanowski John Q: Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a journal of neurology 141 (7): 2181-2193,2018.

Deming Yuetiva, Dumitrescu Logan, Barnes Lisa L, Thambisetty Madhav, Kunkle Brian, Gifford Katherine A, Bush William S, Chibnik Lori B, Mukherjee Shubhabrata, De Jager Philip L, Kukull Walter, Huentelman Matt, Crane Paul K, Resnick Susan M, Keene C Dirk, Montine Thomas J, Schellenberg Gerard D, Haines Jonathan L, Zetterberg Henrik, Blennow Kaj, Larson Eric B, Johnson Sterling C, Albert Marilyn, Moghekar Abhay, Del Aguila Jorge L, Fernandez Maria Victoria, Budde John, Hassenstab Jason, Fagan Anne M, Li Gail: Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta neuropathologica : 2018.

View all publications

Academic Contact Info

Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building

Philadelphia, PA 19104-4283
Phone: (215) 662-6399
Patient appointments: 800-789-7366 (PENN)

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