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John Q. Trojanowski, MD, PhD

John Q. Trojanowski, MD, PhD Physician

Director of the Institute on Aging Director, Medical Pathology William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology

Languages spoken:

  • German

Dr. Trojanowski is employed by Penn Medicine.

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  1. He or she is not employed by Penn Medicine.
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About Dr. John Q. Trojanowski

My areas of clinical expertise include morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1981
  • Pathology - Neuropathology, 1981

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Homestead Smart Health Plans
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Tufts University School of Medicine
Residency: Mount Auburn Hospital
Residency: Massachusetts General Hospital
Residency: Hospital of the University of Pennsylvania

Memberships

Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, National Alzheimer's Association, Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, International American Academy of Neurology (Consultant, Potamkin Award Subcommittee), American Academy of Neurology (Consultant, Potamkin Award), American Academy of Neurology, American Association of Neuropathologists, American Association of Pathologists, American Board of Pathology, American Brain Tumor Association, American Federation for Aging Research National Scientific Advisory Council, American Health Assistance Foundation Alzheimer's Disease Research Review Committee, American Society for Cell Biology, American Society for Clinical Investigators, American Society for Investigative Pathology, Amyotrophic Lateral Sclerosis Association Grant Review Committee, Association of American Physicians, Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, National Dystonia Medical Research Foundation, Elwyn Institute, Elwyn, PA, EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), National Harvard Brain Tissue Resource Center, Institute of Medicine Class of 2002, Institute on Aging, International Academy of Pathology, Abstract Review Board member, Killam Research Fellowship Program, The Canada Council, MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, National National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, National National Campaign to End Neurological Disorders (END)), National Cancer Institute, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, Board of Scientific Councilors, National Institute on Aging, National Advisory Council on Aging (NACA), National Institutes of Child Health and Human Development, National Institutes of Health Grant Study Section Reviewers Reserve, National Institutes of Health Neurology A Study Section, National Institutes of Health Pathology A Study Section, National Institutes of Health, National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, National Institutes of Neurologic Disorders and Stroke, National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, National Sleep Foundation, National Sleep Foundation, Neuroscience Interest Group of the Institute of Medicine, National Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, National NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, National Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, Society for Neuroscience, Society for Neuroscience, The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, National The Institute for the Study of Aging, University of Pittsburgh Alzheimer’s Disease Research Center, University of Washington Alzheimer's Disease Research Center,

Hospital Affiliation

Dr. Trojanowski is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications:

Cali Christopher P, Patino Maribel, Tai Yee Kit, Ho Wan Yun, McLean Catriona A, Morris Christopher M, Seeley William W, Miller Bruce L, Gaig Carles, Vonsattel Jean Paul G, White Charles L, Roeber Sigrun, Kretzschmar Hans, Troncoso Juan C, Troakes Claire, Gearing Marla, Ghetti Bernardino, Van Deerlin Vivianna M, Lee Virginia M-Y, Trojanowski John Q, Mok Kin Y, Ling Helen, Dickson Dennis W, Schellenberg Gerard D, Ling Shuo-Chien, Lee Edward B: C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. Acta neuropathologica 138 (5): 795-811,2019.

Spotorno Nicola, Hall Sara, Irwin David J, Rumetshofer Theodor, Acosta-Cabronero Julio, Deik Andres F, Spindler Meredith A, Lee Edward B, Trojanowski John Q, van Westen Danielle, Nilsson Markus, Grossman Murray, Nestor Peter J, McMillan Corey T, Hansson Oskar: Diffusion Tensor MRI to Distinguish Progressive Supranuclear Palsy from α-Synucleinopathies. Radiology : 190406,2019.

Prokop Stefan, Miller Kelly R, Labra Sergio R, Pitkin Rose M, Hoxha Kevt'her, Narasimhan Sneha, Changolkar Lakshmi, Rosenbloom Alyssa, Lee Virginia M-Y, Trojanowski John Q: Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta neuropathologica 138 (4): 613-630,2019.

Uemura Norihito, Uemura Maiko T, Lo Angela, Bassil Fares, Zhang Bin, Luk Kelvin C, Lee Virginia M-Y, Takahashi Ryosuke, Trojanowski John Q: Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy. Journal of neuropathology and experimental neurology 78 (10): 877-890,2019.

Chu Yaping, Muller Scott, Tavares Adriana, Barret Olivier, Alagille David, Seibyl John, Tamagnan Gilles, Marek Ken, Luk Kelvin C, Trojanowski John Q, Lee Virginia M Y, Kordower Jeffrey H: Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes. Brain : a journal of neurology : 2019.

Posavi Marijan, Diaz-Ortiz Maria, Liu Benjamine, Swanson Christine R, Skrinak R Tyler, Hernandez-Con Pilar, Amado Defne A, Fullard Michelle, Rick Jacqueline, Siderowf Andrew, Weintraub Daniel, McCluskey Leo, Trojanowski John Q, Dewey Richard B, Huang Xuemei, Chen-Plotkin Alice S: Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis. PLoS medicine 16 (10): e1002931,2019.

Caswell Carrie, McMillan Corey T, Xie Sharon X, Van Deerlin Vivianna M, Suh EunRan, Lee Edward B, Trojanowski John Q, Lee Virginia M-Y, Irwin David J, Grossman Murray, Massimo Lauren M: Genetic predictors of survival in behavioral variant frontotemporal degeneration. Neurology : 2019.

Mollenhauer Brit, Caspell-Garcia Chelsea J, Coffey Christopher S, Taylor Peggy, Singleton Andy, Shaw Leslie M, Trojanowski John Q, Frasier Mark, Simuni Tanya, Iranzo Alex, Oertel Wolfgang, Siderowf Andrew, Weintraub Daniel, Seibyl John, Toga Arthur W, Tanner Caroline M, Kieburtz Karl, Chahine Lana M, Marek Kenneth, Galasko Douglas: Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 34 (9): 1354-1364,2019.

Kunkle Brian W, Grenier-Boley Benjamin, Sims Rebecca, Bis Joshua C, Damotte Vincent, Naj Adam C, Boland Anne, Vronskaya Maria, van der Lee Sven J, Amlie-Wolf Alexandre, Bellenguez Céline, Frizatti Aura, Chouraki Vincent, Martin Eden R, Sleegers Kristel, Badarinarayan Nandini, Jakobsdottir Johanna, Hamilton-Nelson Kara L, Moreno-Grau Sonia, Olaso Robert, Raybould Rachel, Chen Yuning, Kuzma Amanda B, Hiltunen Mikko, Morgan Taniesha, Ahmad Shahzad, Vardarajan Badri N, Epelbaum Jacques, Hoffmann Per, Qu Liming: Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature genetics 51 (9): 1423-1424,2019.

Dumitrescu Logan, Barnes Lisa L, Thambisetty Madhav, Beecham Gary, Kunkle Brian, Bush William S, Gifford Katherine A, Chibnik Lori B, Mukherjee Shubhabrata, De Jager Philip L, Kukull Walter, Crane Paul K, Resnick Susan M, Keene C Dirk, Montine Thomas J, Schellenberg Gerard D, Deming Yuetiva, Chao Michael J, Huentelman Matt, Martin Eden R, Hamilton-Nelson Kara, Shaw Leslie M, Trojanowski John Q, Peskind Elaine R, Cruchaga Carlos, Pericak-Vance Margaret A, Goate Alison M, Cox Nancy J, Haines Jonathan L: Sex differences in the genetic predictors of Alzheimer's pathology. Brain : a journal of neurology 142 (9): 2581-2589,2019.

View all publications

Academic Contact Info

Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building

Philadelphia, PA 19104-4283
Phone: (215) 662-6399
Patient appointments: 800-789-7366 (PENN)

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