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John Q. Trojanowski, MD, PhD

John Q. Trojanowski, MD, PhD Physician

Director of the Institute on Aging Director, Medical Pathology William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology

Languages spoken:

  • German

Dr. Trojanowski is employed by Penn Medicine.

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  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients in a medical practice setting.
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Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1981
  • Pathology - Neuropathology, 1981

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Homestead Smart Health Plans
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Tufts University School of Medicine
Residency: Mount Auburn Hospital
Residency: Massachusetts General Hospital
Residency: Hospital of the University of Pennsylvania

Memberships

Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, National Alzheimer's Association, Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, International American Academy of Neurology (Consultant, Potamkin Award Subcommittee), American Academy of Neurology (Consultant, Potamkin Award), American Academy of Neurology, American Association of Neuropathologists, American Association of Pathologists, American Board of Pathology, American Brain Tumor Association, American Federation for Aging Research National Scientific Advisory Council, American Health Assistance Foundation Alzheimer's Disease Research Review Committee, American Society for Cell Biology, American Society for Clinical Investigators, American Society for Investigative Pathology, Amyotrophic Lateral Sclerosis Association Grant Review Committee, Association of American Physicians, Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, National Dystonia Medical Research Foundation, Elwyn Institute, Elwyn, PA, EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), National Harvard Brain Tissue Resource Center, Institute of Medicine Class of 2002, Institute on Aging, International Academy of Pathology, Abstract Review Board member, Killam Research Fellowship Program, The Canada Council, MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, National National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, National National Campaign to End Neurological Disorders (END)), National Cancer Institute, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, Board of Scientific Councilors, National Institute on Aging, National Advisory Council on Aging (NACA), National Institutes of Child Health and Human Development, National Institutes of Health Grant Study Section Reviewers Reserve, National Institutes of Health Neurology A Study Section, National Institutes of Health Pathology A Study Section, National Institutes of Health, National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, National Institutes of Neurologic Disorders and Stroke, National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, National Sleep Foundation, National Sleep Foundation, Neuroscience Interest Group of the Institute of Medicine, National Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, National NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, National Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, Society for Neuroscience, Society for Neuroscience, The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, National The Institute for the Study of Aging, University of Pittsburgh Alzheimer’s Disease Research Center, University of Washington Alzheimer's Disease Research Center,

Hospital Affiliation

Dr. Trojanowski is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications:

Spiller Krista J, Khan Tahiyana, Dominique Myrna A, Restrepo Clark R, Cotton-Samuel Dejania, Levitan Maya, Jafar-Nejad Paymaan, Zhang Bin, Soriano Armand, Rigo Frank, Trojanowski John Q, Lee Virginia M-Y: Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice. Neurobiology of disease 124 : 133-140,2019.

Tropea Thomas F, Mak Jordan, Guo Michael H, Xie Sharon X, Suh Eunran, Rick Jacqueline, Siderowf Andrew, Weintraub Daniel, Grossman Murray, Irwin David, Wolk David A, Trojanowski John Q, Van Deerlin Vivianna, Chen-Plotkin Alice S: TMEM106B Effect on Cognition in Parkinson's Disease and Frontotemporal Dementia. Annals of neurology : 2019.

Guerreiro Rita, Escott-Price Valentina, Hernandez Dena G, Kun-Rodrigues Celia, Ross Owen A, Orme Tatiana, Neto Joao Luis, Carmona Susana, Dehghani Nadia, Eicher John D, Shepherd Claire, Parkkinen Laura, Darwent Lee, Heckman Michael G, Scholz Sonja W, Troncoso Juan C, Pletnikova Olga, Dawson Ted, Rosenthal Liana, Ansorge Olaf, Clarimon Jordi, Lleo Alberto, Morenas-Rodriguez Estrella, Clark Lorraine, Honig Lawrence S, Marder Karen, Lemstra Afina, Rogaeva Ekaterina, St George-Hyslop Peter, Londos Elisabet: Heritability and genetic variance of dementia with Lewy bodies. Neurobiology of disease 127 : 492-501,2019.

Stewart Tessandra, Shi Min, Mehrotra Aanchal, Aro Patrick, Soltys David, Kerr Kathleen F, Zabetian Cyrus P, Peskind Elaine R, Taylor Peggy, Shaw Leslie M, Trojanowski John Q, Zhang Jing: Impact of Pre-Analytical Differences on Biomarkers in the ADNI and PPMI Studies: Implications in the Era of Classifying Disease Based on Biomarkers. Journal of Alzheimer's disease : JAD : 2019.

Smith Douglas H, Johnson Victoria E, Trojanowski John Q, Stewart William: Chronic traumatic encephalopathy - confusion and controversies. Nature reviews. Neurology 15 (3): 179-183,2019.

Stewart William, Allinson Kieren, Al-Sarraj Safa, Bachmeier Corbin, Barlow Karen, Belli Antonio, Burns Mark P, Carson Alan, Crawford Fiona, Dams-O'Connor Kristen, Diaz-Arrastia Ramon, Dixon C Edward, Edlow Brian L, Ferguson Scott, Fischl Bruce, Folkerth Rebecca D, Gentleman Steve, Giza Christopher C, Grady M Sean, Helmy Adel, Herceg Mark, Holton Janice L, Howell David, Hutchinson Peter J, Iacono Diego, Iglesias Juan E, Ikonomovic Milos D, Johnson Victoria E, Keene C Dirk, Kofler Julia K, Lee Edward B: Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology 18 (3): 231-233,2019.

Gibbons Garrett S, Kim Soo-Jung, Robinson John L, Changolkar Lakshmi, Irwin David J, Shaw Leslie M, Lee Virginia M-Y, Trojanowski John Q: Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau). Acta neuropathologica communications 7 (1): 34,2019.

Schindler Suzanne E, Li Yan, Todd Kaitlin W, Herries Elizabeth M, Henson Rachel L, Gray Julia D, Wang Guoqiao, Graham Danielle L, Shaw Leslie M, Trojanowski John Q, Hassenstab Jason J, Benzinger Tammie L S, Cruchaga Carlos, Jucker Mathias, Levin Johannes, Chhatwal Jasmeer P, Noble James M, Ringman John M, Graff-Radford Neill R, Holtzman David M, Ladenson Jack H, Morris John C, Bateman Randall J, Xiong Chengjie, Fagan Anne M: Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association : 2019.

Giannini Lucia A A, Xie Sharon X, McMillan Corey T, Liang Mendy, Williams Andrew, Jester Charles, Rascovsky Katya, Wolk David A, Ash Sharon, Lee Edward B, Trojanowski John Q, Grossman Murray, Irwin David J: Divergent patterns of TDP-43 and tau pathologies in primary progressive aphasia. Annals of neurology : 2019.

Kun-Rodrigues Celia, Orme Tatiana, Carmona Susana, Hernandez Dena G, Ross Owen A, Eicher John D, Shepherd Claire, Parkkinen Laura, Darwent Lee, Heckman Michael G, Scholz Sonja W, Troncoso Juan C, Pletnikova Olga, Dawson Ted, Rosenthal Liana, Ansorge Olaf, Clarimon Jordi, Lleo Alberto, Morenas-Rodriguez Estrella, Clark Lorraine, Honig Lawrence S, Marder Karen, Lemstra Afina, Rogaeva Ekaterina, St George-Hyslop Peter, Londos Elisabet, Zetterberg Henrik, Barber Imelda, Braae Anne, Brown Kristelle, Pastor Pau: A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of aging 75 : 223.e1-223.e10,2019.

View all publications

Academic Contact Info

Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building

Philadelphia, PA 19104-4283
Phone: (215) 662-6399
Patient appointments: 800-789-7366 (PENN)

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