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John Q. Trojanowski, MD, PhD

John Q. Trojanowski, MD, PhD Physician

Director of the Institute on Aging Director, Medical Pathology William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology

Languages spoken:

  • German

Dr. Trojanowski is a Penn Medicine employed physician.

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  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
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Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1981
  • Pathology - Neuropathology, 1981

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Tufts University School of Medicine
Residency: Mount Auburn Hospital
Residency: Massachusetts General Hospital
Residency: Hospital of the University of Pennsylvania

Memberships

Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, National Alzheimer's Association, Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, International American Academy of Neurology (Consultant, Potamkin Award Subcommittee), American Academy of Neurology (Consultant, Potamkin Award), American Academy of Neurology, American Association of Neuropathologists, American Association of Pathologists, American Board of Pathology, American Brain Tumor Association, American Federation for Aging Research National Scientific Advisory Council, American Health Assistance Foundation Alzheimer's Disease Research Review Committee, American Society for Cell Biology, American Society for Clinical Investigators, American Society for Investigative Pathology, Amyotrophic Lateral Sclerosis Association Grant Review Committee, Association of American Physicians, Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, National Dystonia Medical Research Foundation, Elwyn Institute, Elwyn, PA, EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), National Harvard Brain Tissue Resource Center, Institute of Medicine Class of 2002, Institute on Aging, International Academy of Pathology, Abstract Review Board member, Killam Research Fellowship Program, The Canada Council, MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, National National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, National National Campaign to End Neurological Disorders (END)), National Cancer Institute, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, Board of Scientific Councilors, National Institute on Aging, National Advisory Council on Aging (NACA), National Institutes of Child Health and Human Development, National Institutes of Health Grant Study Section Reviewers Reserve, National Institutes of Health Neurology A Study Section, National Institutes of Health Pathology A Study Section, National Institutes of Health, National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, National Institutes of Neurologic Disorders and Stroke, National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, National Sleep Foundation, National Sleep Foundation, Neuroscience Interest Group of the Institute of Medicine, National Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, National NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, National Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, Society for Neuroscience, Society for Neuroscience, The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, National The Institute for the Study of Aging, University of Pittsburgh Alzheimer’s Disease Research Center, University of Washington Alzheimer's Disease Research Center,

Hospital Affiliation

Dr. Trojanowski is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications:

Irwin David J, Grossman Murray, Weintraub Daniel, Hurtig Howard I, Duda John E, Xie Sharon X, Lee Edward B, Van Deerlin Vivianna M, Lopez Oscar L, Kofler Julia K, Nelson Peter T, Jicha Gregory A, Woltjer Randy, Quinn Joseph F, Kaye Jeffery, Leverenz James B, Tsuang Debby, Longfellow Katelan, Yearout Dora, Kukull Walter, Keene C Dirk, Montine Thomas J, Zabetian Cyrus P, Trojanowski John Q: Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. The Lancet. Neurology 16 (1): 55-65,2017.

Brown Christopher A, Johnson Nathan F, Anderson-Mooney Amelia J, Jicha Gregory A, Shaw Leslie M, Trojanowski John Q, Van Eldik Linda J, Schmitt Frederick A, Smith Charles D, Gold Brian T: Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease. NeuroImage. Clinical 13 : 106-115,2017.

Brunden Kurt R, Lee Virginia M-Y, Smith Amos B, Trojanowski John Q, Ballatore Carlo: Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs. Neurobiology of disease : 2016.

Kovacs Gabor G, Kwong Linda K, Grossman Murray, Irwin David J, Lee Edward B, Robinson John L, Suh Eunran, Van Deerlin Vivianna M, Lee Virginia M, Trojanowski John Q: Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland) : 2016.

McMillan Corey T, Irwin David J, Nasrallah Ilya, Phillips Jeffrey S, Spindler Meredith, Rascovsky Katya, Ternes Kylie, Jester Charles, Wolk David A, Kwong Linda K, Lee Virginia M-Y, Lee Edward B, Trojanowski John Q, Grossman Murray: Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. Acta neuropathologica 132 (6): 935-937,2016.

Weiner Michael W, Veitch Dallas P, Aisen Paul S, Beckett Laurel A, Cairns Nigel J, Green Robert C, Harvey Danielle, Jack Clifford R, Jagust William, Morris John C, Petersen Ronald C, Salazar Jennifer, Saykin Andrew J, Shaw Leslie M, Toga Arthur W, Trojanowski John Q: The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement. Alzheimer's & dementia : the journal of the Alzheimer's Association : 2016.

Chapuis Julien, Flaig Amandine, Grenier-Boley Benjamin, Eysert Fanny, Pottiez Virginie, Deloison Gaspard, Vandeputte Alexandre, Ayral Anne-Marie, Mendes Tiago, Desai Shruti, Goate Alison M, Kauwe John S K, Leroux Florence, Herledan Adrien, Demiautte Florie, Bauer Charlotte, Checler Fréderic, Petersen Ronald C, Blennow Kaj, Zetterberg Henrik, Minthon Lennart, Van Deerlin Vivianna M, Lee Virginia Man-Yee, Shaw Leslie M, Trojanowski John Q, Albert Marilyn, Moghekar Abhay, O'Brien Richard, Peskind Elaine R, Mal: Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta neuropathologica : 2016.

Dong Aoyan, Toledo Jon B, Honnorat Nicolas, Doshi Jimit, Varol Erdem, Sotiras Aristeidis, Wolk David, Trojanowski John Q, Davatzikos Christos: Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers. Brain : a journal of neurology : 2016.

Guo Jing L, Narasimhan Sneha, Changolkar Lakshmi, He Zhuohao, Stieber Anna, Zhang Bin, Gathagan Ronald J, Iba Michiyo, McBride Jennifer D, Trojanowski John Q, Lee Virginia M Y: Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. The Journal of experimental medicine 213 (12): 2635-2654,2016.

Khanna Mansi R, Kovalevich Jane, Lee Virginia M-Y, Trojanowski John Q, Brunden Kurt R: Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimer's & dementia : the journal of the Alzheimer's Association 12 (10): 1051-1065,2016.

View all publications

Academic Contact Info

Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building

Philadelphia, PA 19104-4283
Phone: (215) 662-6399
Fax: (215) 349-5909
Patient appointments: 800-789-7366 (PENN)

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