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John Q. Trojanowski, MD, PhD

John Q. Trojanowski, MD, PhD Physician

Director of the Institute on Aging Director, Medical Pathology William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology

Languages spoken:

  • German

Dr. Trojanowski is a Penn Medicine employed physician.

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  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
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Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1981
  • Pathology - Neuropathology, 1981

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Tufts University School of Medicine
Residency: Mount Auburn Hospital
Residency: Massachusetts General Hospital
Residency: Hospital of the University of Pennsylvania

Memberships

8th International Conference on Progress in Alzheimer's and Parkinson's Disease, International Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, National Alzheimer's Association, Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, International American Academy of Neurology (Consultant, Potamkin Award Subcommittee), American Academy of Neurology (Consultant, Potamkin Award), American Academy of Neurology, American Association of Neuropathologists, American Association of Pathologists, American Board of Pathology, American Brain Tumor Association, American Federation for Aging Research National Scientific Advisory Council , American Health Assistance Foundation Alzheimer's Disease Research Review Committee, American Society for Cell Biology , American Society for Clinical Investigators, American Society for Investigative Pathology, Amyotrophic Lateral Sclerosis Association Grant Review Committee, Association of American Physicians, Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review , National Dystonia Medical Research Foundation, Elwyn Institute, Elwyn, PA, EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), National Harvard Brain Tissue Resource Center, Institute of Medicine Class of 2002, Institute on Aging, International Academy of Pathology, Abstract Review Board member, Killam Research Fellowship Program, The Canada Council, Member, Alzheimer 100 Scientific Advisory Board on the centennial of the presentation by Alois Alzheimer of the Auguste D. case in Tubingen on November 3, 1906, International Member, NINDS Morris K. Udall Parkinson’s Disease Center Coordinating Committee, National MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, National National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, National National Campaign to End Neurological Disorders (END)), National Cancer Institute , National Institute on Aging , National Institute on Aging , National Institute on Aging, National Institute on Aging, Board of Scientific Councilors , National Institute on Aging, National Advisory Council on Aging (NACA), National Institutes of Child Health and Human Development, National Institutes of Health Grant Study Section Reviewers Reserve , National Institutes of Health Neurology A Study Section, National Institutes of Health Pathology A Study Section, National Institutes of Health, National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee , National Institutes of Neurologic Disorders and Stroke, National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, National Sleep Foundation , National Sleep Foundation , Neuroscience Interest Group of the Institute of Medicine, National Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders , National NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, National Organizing Committee, 8th International Conference On Progress In Alzheimer’s And Parkinson’s Disease, Salzburg, Austria , International Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, Society for Neuroscience , Society for Neuroscience, The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, National The Gerontological Society of America (GSA), Task Force on Research Committee, National The Institute for the Study of Aging, University of Pittsburgh Alzheimer’s Disease Research Center, University of Washington Alzheimer's Disease Research Center,

Hospital Affiliation

Dr. Trojanowski is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications:

Brennan Laura, Devlin Kathryn M, Xie Sharon X, Mechanic-Hamilton Dawn, Tran Baochan, Hurtig Howard H, Chen-Plotkin Alice, Chahine Lama M, Morley James F, Duda John E, Roalf David R, Dahodwala Nabila, Rick Jacqueline, Trojanowski John Q, Moberg Paul J, Weintraub Daniel: Neuropsychological Subgroups in Non-Demented Parkinson's Disease: A Latent Class Analysis. Journal of Parkinson's disease : 2017.

Covell Dustin J, Robinson John L, Akhtar Rizwan S, Grossman Murray, Weintraub Daniel, Bucklin Hannah M, Pitkin Rose M, Riddle Dawn, Yousef Ahmed, Trojanowski John Q, Lee Virginia M-Y: Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease. Neuropathology and applied neurobiology : 2017.

Gendron Tania F, Chew Jeannie, Stankowski Jeannette N, Hayes Lindsey R, Zhang Yong-Jie, Prudencio Mercedes, Carlomagno Yari, Daughrity Lillian M, Jansen-West Karen, Perkerson Emilie A, O'Raw Aliesha, Cook Casey, Pregent Luc, Belzil Veronique, van Blitterswijk Marka, Tabassian Lilia J, Lee Chris W, Yue Mei, Tong Jimei, Song Yuping, Castanedes-Casey Monica, Rousseau Linda, Phillips Virginia, Dickson Dennis W, Rademakers Rosa, Fryer John D, Rush Beth K, Pedraza Otto, Caputo Ana M, Desaro Pamela, Palmucci Carla: Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science translational medicine 9 (383): 2017.

Ono Maiko, Sahara Naruhiko, Kumata Katsushi, Ji Bin, Ni Ruiqing, Koga Shunsuke, Dickson Dennis W, Trojanowski John Q, Lee Virginia M-Y, Yoshida Mari, Hozumi Isao, Yoshiyama Yasumasa, van Swieten John C, Nordberg Agneta, Suhara Tetsuya, Zhang Ming-Rong, Higuchi Makoto: Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain : a journal of neurology 140 (3): 764-780,2017.

Spinelli Edoardo G, Mandelli Maria Luisa, Miller Zachary A, Santos-Santos Miguel A, Wilson Stephen M, Agosta Federica, Grinberg Lea T, Huang Eric J, Trojanowski John Q, Meyer Marita, Henry Maya L, Comi Giancarlo, Rabinovici Gil, Rosen Howard J, Filippi Massimo, Miller Bruce L, Seeley William W, Gorno-Tempini Maria Luisa: Typical and atypical pathology in primary progressive aphasia variants. Annals of neurology 81 (3): 430-443,2017.

Kovacs Gabor G, Robinson John L, Xie Sharon X, Lee Edward B, Grossman Murray, Wolk David A, Irwin David J, Weintraub Dan, Kim Christopher F, Schuck Theresa, Yousef Ahmed, Wagner Stephanie T, Suh Eunran, Van Deerlin Vivianna M, Lee Virginia M-Y, Trojanowski John Q: Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. Journal of neuropathology and experimental neurology : 2017.

Toledo Jon B, Arnold Matthias, Kastenmüller Gabi, Chang Rui, Baillie Rebecca A, Han Xianlin, Thambisetty Madhav, Tenenbaum Jessica D, Suhre Karsten, Thompson J Will, John-Williams Lisa St, MahmoudianDehkordi Siamak, Rotroff Daniel M, Jack John R, Motsinger-Reif Alison, Risacher Shannon L, Blach Colette, Lucas Joseph E, Massaro Tyler, Louie Gregory, Zhu Hongjie, Dallmann Guido, Klavins Kristaps, Koal Therese, Kim Sungeun, Nho Kwangsik, Shen Li, Casanova Ramon, Varma Sudhir, Legido-Quigley Cristina, Moseley M: Metabolic network failures in Alzheimer's disease-A biochemical road map. Alzheimer's & dementia : the journal of the Alzheimer's Association : 2017.

Weiner Michael W, Veitch Dallas P, Aisen Paul S, Beckett Laurel A, Cairns Nigel J, Green Robert C, Harvey Danielle, Jack Clifford R, Jagust William, Morris John C, Petersen Ronald C, Saykin Andrew J, Shaw Leslie M, Toga Arthur W, Trojanowski John Q: Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials. Alzheimer's & dementia : the journal of the Alzheimer's Association : 2017.

Deming Yuetiva, Li Zeran, Kapoor Manav, Harari Oscar, Del-Aguila Jorge L, Black Kathleen, Carrell David, Cai Yefei, Fernandez Maria Victoria, Budde John, Ma Shengmei, Saef Benjamin, Howells Bill, Huang Kuan-Lin, Bertelsen Sarah, Fagan Anne M, Holtzman David M, Morris John C, Kim Sungeun, Saykin Andrew J, De Jager Philip L, Albert Marilyn, Moghekar Abhay, O'Brien Richard, Riemenschneider Matthias, Petersen Ronald C, Blennow Kaj, Zetterberg Henrik, Minthon Lennart, Van Deerlin Vivianna M, Lee Virginia Man-Yee: Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta neuropathologica : 2017.

Sposato Luciano A, Ruíz Vargas Estefanía, Riccio Patricia M, Toledo Jon B, Trojanowski John Q, Kukull Walter A, Cipriano Lauren E, Nucera Antonia, Whitehead Shawn N, Hachinski Vladimir: Milder Alzheimer's disease pathology in heart failure and atrial fibrillation. Alzheimer's & dementia : the journal of the Alzheimer's Association : 2017.

View all publications

Academic Contact Info

Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building

Philadelphia, PA 19104-4283
Phone: (215) 662-6399
Fax: (215) 349-5909
Patient appointments: 800-789-7366 (PENN)

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