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John Q. Trojanowski, MD, PhD

John Q. Trojanowski, MD, PhD Physician

Director of the Institute on Aging
Director, Medical Pathology
William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology

Languages spoken:

  • German
No Patient Satisfaction Reviews
Why not?

There is no publicly available rating for this medical professional for one of the following reasons:

  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
  3. He or she sees patients but has not yet received the minimum 30 patient satisfaction reviews in the past 12 months, ensuring that the rating is statistically reliable and a true reflection of patient satisfaction.

Dr. Trojanowski is a Penn Medicine employed physician.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1981
  • Pathology - Neuropathology, 1981

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Multiplan
  • NJ Qualcare
  • Oxford Health Plan
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Tufts University School of Medicine
Residency: Mount Auburn Hospital
Residency: Massachusetts General Hospital
Residency: Hospital of the University of Pennsylvania


Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, National Alzheimer's Association, Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, International American Academy of Neurology (Consultant, Potamkin Award Subcommittee), American Academy of Neurology (Consultant, Potamkin Award), American Academy of Neurology, American Association of Neuropathologists, American Association of Pathologists, American Board of Pathology, American Brain Tumor Association, American Federation for Aging Research National Scientific Advisory Council, American Health Assistance Foundation Alzheimer's Disease Research Review Committee, American Society for Cell Biology, American Society for Clinical Investigators, American Society for Investigative Pathology, Amyotrophic Lateral Sclerosis Association Grant Review Committee, Association of American Physicians, Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, National Dystonia Medical Research Foundation, Elwyn Institute, Elwyn, PA, EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), National Harvard Brain Tissue Resource Center, Institute of Medicine Class of 2002, Institute on Aging, International Academy of Pathology, Abstract Review Board member, Killam Research Fellowship Program, The Canada Council, MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, National National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, National National Campaign to End Neurological Disorders (END)), National Cancer Institute, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, Board of Scientific Councilors, National Institute on Aging, National Advisory Council on Aging (NACA), National Institutes of Child Health and Human Development, National Institutes of Health Grant Study Section Reviewers Reserve, National Institutes of Health Neurology A Study Section, National Institutes of Health Pathology A Study Section, National Institutes of Health, National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, National Institutes of Neurologic Disorders and Stroke, National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, National Sleep Foundation, National Sleep Foundation, Neuroscience Interest Group of the Institute of Medicine, National Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, National NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, National Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, Society for Neuroscience, Society for Neuroscience, The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, National The Institute for the Study of Aging, University of Pittsburgh Alzheimer’s Disease Research Center, University of Washington Alzheimer's Disease Research Center,

Hospital Affiliation

Dr. Trojanowski is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications:

Imamura Keiko, Sahara Naruhiko, Kanaan Nicholas M, Tsukita Kayoko, Kondo Takayuki, Kutoku Yumiko, Ohsawa Yutaka, Sunada Yoshihide, Kawakami Koichi, Hotta Akitsu, Yawata Satoshi, Watanabe Dai, Hasegawa Masato, Trojanowski John Q, Lee Virginia M-Y, Suhara Tetsuya, Higuchi Makoto, Inoue Haruhisa: Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. Scientific reports 6 : 34904,2016.

Davis Marie Y, Johnson Catherine O, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Chen-Plotkin Alice, Van Deerlin Vivianna M, Quinn Joseph F, Chung Kathryn A, Peterson-Hiller Amie L, Rosenthal Liana S, Dawson Ted M, Albert Marilyn S, Goldman Jennifer G, Stebbins Glenn T, Bernard Bryan, Wszolek Zbigniew K, Ross Owen A, Dickson Dennis W, Eidelberg David, Mattis Paul J, Niethammer Martin, Yearout Dora, Hu Shu-Ching, Cholerton Brenna A, Smith Megan, Mata Ignacio F, Montine Thomas J, Edwards Karen L, Z: Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease. JAMA neurology 73 (10): 1217-1224,2016.

Brettschneider Johannes, Irwin David J, Boluda Susana, Byrne Matthew D, Fang Lubin, Lee Edward B, Robinson John L, Suh EunRan, Van Deerlin Vivianna M, Toledo Jon B, Grossman Murray, Hurtig Howard, Dengler Reinhard, Petri Susanne, Lee Virginia M-Y, Trojanowski John Q: Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type. Neuropathology and applied neurobiology : 2016.

Wisse L E M, Adler D H, Ittyerah R, Pluta J B, Robinson J L, Schuck T, Trojanowski J Q, Grossman M, Detre J A, Elliott M A, Toledo J B, Liu W, Pickup S, Das S R, Wolk D A, Yushkevich P A: Comparison of In Vivo and Ex Vivo MRI of the Human Hippocampal Formation in the Same Subjects. Cerebral cortex (New York, N.Y. : 1991) : 2016.

Kun-Rodrigues Celia, Ross Owen A, Orme Tatiana, Shepherd Claire, Parkkinen Laura, Darwent Lee, Hernandez Dena, Ansorge Olaf, Clark Lorraine N, Honig Lawrence S, Marder Karen, Lemstra Afina, Scheltens Philippe, van der Flier Wiesje, Louwersheimer Eva, Holstege Henne, Rogaeva Ekaterina, St George-Hyslop Peter, Londos Elisabet, Zetterberg Henrik, Barber Imelda, Braae Anne, Brown Kristelle, Morgan Kevin, Maetzler Walter, Berg Daniela, Troakes Claire, Al-Sarraj Safa, Lashley Tammaryn, Holton Janice, Compta Yaros: Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies. Neurobiology of aging : 2016.

Placek Katerina, Massimo Lauren, Olm Christopher, Ternes Kylie, Firn Kim, Van Deerlin Vivianna, Lee Edward B, Trojanowski John Q, Lee Virginia M-Y, Irwin David, Grossman Murray, McMillan Corey T: Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence. Neurology : 2016.

Spiller Krista J, Restrepo Clark R, Khan Tahiyana, Stieber Anna M, Kwong Linda K, Trojanowski John Q, Lee Virginia M-Y: Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice. Acta neuropathologica communications 4 (1): 105,2016.

Makani Vishruti, Zhang Bin, Han Heeoon, Yao Yuemang, Lassalas Pierrik, Lou Kevin, Paterson Ian, Lee Virginia M Y, Trojanowski John Q, Ballatore Carlo, Smith Amos B, Brunden Kurt R: Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta neuropathologica communications 4 (1): 106,2016.

James Bryan D, Wilson Robert S, Boyle Patricia A, Trojanowski John Q, Bennett David A, Schneider Julie A: TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia. Brain : a journal of neurology : 2016.

Mattsson Niklas, Zetterberg Henrik, Janelidze Shorena, Insel Philip S, Andreasson Ulf, Stomrud Erik, Palmqvist Sebastian, Baker David, Tan Hehir Cristina A, Jeromin Andreas, Hanlon David, Song Linan, Shaw Leslie M, Trojanowski John Q, Weiner Michael W, Hansson Oskar, Blennow Kaj: Plasma tau in Alzheimer disease. Neurology : 2016.

View all publications

Academic Contact Info

Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building

Philadelphia, PA 19104-4283
Phone: (215) 662-6399
Fax: (215) 349-5909

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