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John Q. Trojanowski, MD, PhD

John Q. Trojanowski, MD, PhD Physician

Director of the Institute on Aging
Director, Medical Pathology
William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology

Languages spoken:

  • German

Dr. Trojanowski is a Penn Medicine employed physician.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1981
  • Pathology - Neuropathology, 1981

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Tufts University School of Medicine
Residency: Mount Auburn Hospital
Residency: Massachusetts General Hospital
Residency: Hospital of the University of Pennsylvania


Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, National Alzheimer's Association, Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, International American Academy of Neurology (Consultant, Potamkin Award Subcommittee), American Academy of Neurology (Consultant, Potamkin Award), American Academy of Neurology, American Association of Neuropathologists, American Association of Pathologists, American Board of Pathology, American Brain Tumor Association, American Federation for Aging Research National Scientific Advisory Council, American Health Assistance Foundation Alzheimer's Disease Research Review Committee, American Society for Cell Biology, American Society for Clinical Investigators, American Society for Investigative Pathology, Amyotrophic Lateral Sclerosis Association Grant Review Committee, Association of American Physicians, Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, National Dystonia Medical Research Foundation, Elwyn Institute, Elwyn, PA, EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), National Harvard Brain Tissue Resource Center, Institute of Medicine Class of 2002, Institute on Aging, International Academy of Pathology, Abstract Review Board member, Killam Research Fellowship Program, The Canada Council, MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, National National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, National National Campaign to End Neurological Disorders (END)), National Cancer Institute, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, Board of Scientific Councilors, National Institute on Aging, National Advisory Council on Aging (NACA), National Institutes of Child Health and Human Development, National Institutes of Health Grant Study Section Reviewers Reserve, National Institutes of Health Neurology A Study Section, National Institutes of Health Pathology A Study Section, National Institutes of Health, National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, National Institutes of Neurologic Disorders and Stroke, National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, National Sleep Foundation, National Sleep Foundation, Neuroscience Interest Group of the Institute of Medicine, National Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, National NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, National Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, Society for Neuroscience, Society for Neuroscience, The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, National The Institute for the Study of Aging, University of Pittsburgh Alzheimer’s Disease Research Center, University of Washington Alzheimer's Disease Research Center,

Hospital Affiliation

Dr. Trojanowski is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications:

Kang Ju-Hee, Mollenhauer Brit, Coffey Christopher S, Toledo Jon B, Weintraub Daniel, Galasko Douglas R, Irwin David J, Van Deerlin Vivianna, Chen-Plotkin Alice S, Caspell-Garcia Chelsea, Waligórska Teresa, Taylor Peggy, Shah Nirali, Pan Sarah, Zero Pawel, Frasier Mark, Marek Kenneth, Kieburtz Karl, Jennings Danna, Tanner Caroline M, Simuni Tanya, Singleton Andrew, Toga Arthur W, Chowdhury Sohini, Trojanowski John Q, Shaw Leslie M: CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study. Acta neuropathologica : 2016.

Toledo Jon B, Gopal Pallavi, Raible Kevin, Irwin David J, Brettschneider Johannes, Sedor Samantha, Waits Kayla, Boluda Susana, Grossman Murray, Van Deerlin Vivianna M, Lee Edward B, Arnold Steven E, Duda John E, Hurtig Howard, Lee Virginia M-Y, Adler Charles H, Beach Thomas G, Trojanowski John Q: Pathological a-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta neuropathologica 131 (3): 393-409,2016.

Kovalevich Jane, Cornec Anne-Sophie, Yao Yuemang, James Michael, Crowe Alexander, Lee Virginia M-Y, Trojanowski John Q, Smith Amos B, Ballatore Carlo, Brunden Kurt R: Characterization of brain-penetrant pyrimidine-containing molecules with differential microtubule-stabilizing activities developed as potential therapeutic agents for Alzheimer's disease and related tauopathies. The Journal of pharmacology and experimental therapeutics : 2016.

Brennan Laura, Siderowf Andrew, Rubright Jonathan D, Rick Jacqueline, Dahodwala Nabila, Duda John E, Hurtig Howard, Stern Matthew, Xie Sharon X, Rennert Lior, Karlawish Jason, Shea Judy A, Trojanowski John Q, Weintraub Daniel: The Penn Parkinson's Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson's disease. Parkinsonism & related disorders : 2016.

Montine Thomas J, Monsell Sarah E, Beach Thomas G, Bigio Eileen H, Bu Yunqi, Cairns Nigel J, Frosch Matthew, Henriksen Jonathan, Kofler Julia, Kukull Walter A, Lee Edward B, Nelson Peter T, Schantz Aimee M, Schneider Julie A, Sonnen Joshua A, Trojanowski John Q, Vinters Harry V, Zhou Xiao-Hua, Hyman Bradley T: Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association 12 (2): 164-9,2016.

Irwin David J, Brettschneider Johannes, McMillan Corey T, Cooper Felicia, Olm Christopher, Arnold Steven E, Van Deerlin Vivianna M, Seeley William W, Miller Bruce L, Lee Edward B, Lee Virginia M-Y, Grossman Murray, Trojanowski John Q: Deep clinical and neuropathological phenotyping of Pick disease. Annals of neurology 79 (2): 272-87,2016.

Kovacs Gabor G, Ferrer Isidro, Grinberg Lea T, Alafuzoff Irina, Attems Johannes, Budka Herbert, Cairns Nigel J, Crary John F, Duyckaerts Charles, Ghetti Bernardino, Halliday Glenda M, Ironside James W, Love Seth, Mackenzie Ian R, Munoz David G, Murray Melissa E, Nelson Peter T, Takahashi Hitoshi, Trojanowski John Q, Ansorge Olaf, Arzberger Thomas, Baborie Atik, Beach Thomas G, Bieniek Kevin F, Bigio Eileen H, Bodi Istvan, Dugger Brittany N, Feany Mel, Gelpi Ellen, Gentleman Stephen M, Giaccone Giorgio, Hata: Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta neuropathologica 131 (1): 87-102,2016.

Mata Ignacio F, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Chen-Plotkin Alice, Van Deerlin Vivianna M, Ritz Beate, Rausch Rebecca, Factor Stewart A, Wood-Siverio Cathy, Quinn Joseph F, Chung Kathryn A, Peterson-Hiller Amie L, Goldman Jennifer G, Stebbins Glenn T, Bernard Bryan, Espay Alberto J, Revilla Fredy J, Devoto Johnna, Rosenthal Liana S, Dawson Ted M, Albert Marilyn S, Tsuang Debby, Huston Haley, Yearout Dora, Hu Shu-Ching, Cholerton Brenna A, Montine Thomas J, Edwards Karen L, Zabetian : GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 31 (1): 95-102,2016.

Zetterberg Henrik, Skillbäck Tobias, Mattsson Niklas, Trojanowski John Q, Portelius Erik, Shaw Leslie M, Weiner Michael W, Blennow Kaj: Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression. JAMA neurology 73 (1): 60-7,2016.

Irwin David J, Byrne Matthew D, McMillan Corey T, Cooper Felicia, Arnold Steven E, Lee Edward B, Van Deerlin Vivianna M, Xie Sharon X, Lee Virginia M-Y, Grossman Murray, Trojanowski John Q: Semi-Automated Digital Image Analysis of Pick's Disease and TDP-43 Proteinopathy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 64 (1): 54-66,2016.

View all publications

Academic Contact Info

Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building

Philadelphia, PA 19104-4283
Phone: (215) 662-6399
Fax: (215) 349-5909

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