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John Q. Trojanowski, MD, PhD

John Q. Trojanowski, MD, PhD Physician

Director of the Institute on Aging Director, Medical Pathology William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology

Languages spoken:

  • German

Dr. Trojanowski is employed by Penn Medicine.

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  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
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Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1981
  • Pathology - Neuropathology, 1981

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Tufts University School of Medicine
Residency: Mount Auburn Hospital
Residency: Massachusetts General Hospital
Residency: Hospital of the University of Pennsylvania

Memberships

Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, National Alzheimer's Association, Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, International American Academy of Neurology (Consultant, Potamkin Award Subcommittee), American Academy of Neurology (Consultant, Potamkin Award), American Academy of Neurology, American Association of Neuropathologists, American Association of Pathologists, American Board of Pathology, American Brain Tumor Association, American Federation for Aging Research National Scientific Advisory Council, American Health Assistance Foundation Alzheimer's Disease Research Review Committee, American Society for Cell Biology, American Society for Clinical Investigators, American Society for Investigative Pathology, Amyotrophic Lateral Sclerosis Association Grant Review Committee, Association of American Physicians, Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, National Dystonia Medical Research Foundation, Elwyn Institute, Elwyn, PA, EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), National Harvard Brain Tissue Resource Center, Institute of Medicine Class of 2002, Institute on Aging, International Academy of Pathology, Abstract Review Board member, Killam Research Fellowship Program, The Canada Council, MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, National National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, National National Campaign to End Neurological Disorders (END)), National Cancer Institute, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, Board of Scientific Councilors, National Institute on Aging, National Advisory Council on Aging (NACA), National Institutes of Child Health and Human Development, National Institutes of Health Grant Study Section Reviewers Reserve, National Institutes of Health Neurology A Study Section, National Institutes of Health Pathology A Study Section, National Institutes of Health, National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, National Institutes of Neurologic Disorders and Stroke, National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, National Sleep Foundation, National Sleep Foundation, Neuroscience Interest Group of the Institute of Medicine, National Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, National NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, National Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, Society for Neuroscience, Society for Neuroscience, The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, National The Institute for the Study of Aging, University of Pittsburgh Alzheimer’s Disease Research Center, University of Washington Alzheimer's Disease Research Center,

Hospital Affiliation

Dr. Trojanowski is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications:

Wenning Gregor, Trojanowski John Q, Kaufmann Horacio, Wisniewski Thomas, Rocca Walter A, Low Phillip A: Is multiple system atrophy an infectious disease? Annals of neurology : 2018.

He Zhuohao, Guo Jing L, McBride Jennifer D, Narasimhan Sneha, Kim Hyesung, Changolkar Lakshmi, Zhang Bin, Gathagan Ronald J, Yue Cuiyong, Dengler Christopher, Stieber Anna, Nitla Magdalena, Coulter Douglas A, Abel Ted, Brunden Kurt R, Trojanowski John Q, Lee Virginia M-Y: Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nature medicine 24 (1): 29-38,2018.

Rey Nolwen L, George Sonia, Steiner Jennifer A, Madaj Zachary, Luk Kelvin C, Trojanowski John Q, Lee Virginia M-Y, Brundin Patrik: Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term. Acta neuropathologica 135 (1): 65-83,2018.

Irwin David J, McMillan Corey T, Xie Sharon X, Rascovsky Katya, Van Deerlin Vivianna M, Coslett H Branch, Hamilton Roy, Aguirre Geoffrey K, Lee Edward B, Lee Virginia M Y, Trojanowski John Q, Grossman Murray: Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain : a journal of neurology 141 (1): 288-301,2018.

Guerreiro Rita, Ross Owen A, Kun-Rodrigues Celia, Hernandez Dena G, Orme Tatiana, Eicher John D, Shepherd Claire E, Parkkinen Laura, Darwent Lee, Heckman Michael G, Scholz Sonja W, Troncoso Juan C, Pletnikova Olga, Ansorge Olaf, Clarimon Jordi, Lleo Alberto, Morenas-Rodriguez Estrella, Clark Lorraine, Honig Lawrence S, Marder Karen, Lemstra Afina, Rogaeva Ekaterina, St George-Hyslop Peter, Londos Elisabet, Zetterberg Henrik, Barber Imelda, Braae Anne, Brown Kristelle, Morgan Kevin, Troakes Claire: Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet. Neurology 17 (1): 64-74,2018.

Wang Hua, Stewart Tessandra, Toledo Jon B, Ginghina Carmen, Tang Lu, Atik Anzari, Aro Patrick, Shaw Leslie M, Trojanowski John Q, Galasko Douglas R, Edland Steven, Jensen Poul H, Shi Min, Zhang Jing: A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD 61 (4): 1541-1553,2018.

Berson Amit, Sartoris Ashley, Nativio Raffaella, Van Deerlin Vivianna, Toledo Jon B, Porta Sílvia, Liu Shichong, Chung Chia-Yu, Garcia Benjamin A, Lee Virginia M-Y, Trojanowski John Q, Johnson F Brad, Berger Shelley L, Bonini Nancy M: TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Current biology : CB 27 (23): 3579-3590.e6,2017.

Horgusluoglu-Moloch Emrin, Nho Kwangsik, Risacher Shannon L, Kim Sungeun, Foroud Tatiana, Shaw Leslie M, Trojanowski John Q, Aisen Paul S, Petersen Ronald C, Jack Clifford R, Lovestone Simon, Simmons Andrew, Weiner Michael W, Saykin Andrew J: Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging 60 : 92-103,2017.

Perry David C, Brown Jesse A, Possin Katherine L, Datta Samir, Trujillo Andrew, Radke Anneliese, Karydas Anna, Kornak John, Sias Ana C, Rabinovici Gil D, Gorno-Tempini Maria Luisa, Boxer Adam L, De May Mary, Rankin Katherine P, Sturm Virginia E, Lee Suzee E, Matthews Brandy R, Kao Aimee W, Vossel Keith A, Tartaglia Maria Carmela, Miller Zachary A, Seo Sang Won, Sidhu Manu, Gaus Stephanie E, Nana Alissa L, Vargas Jose Norberto S, Hwang Ji-Hye L, Ossenkoppele Rik, Brown Alainna B, Huang Eric J, Kramer Joel H: Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain : a journal of neurology 140 (12): 3329-3345,2017.

Phillips Jeffrey S, Da Re Fulvio, Dratch Laynie, Xie Sharon X, Irwin David J, McMillan Corey T, Vaishnavi Sanjeev N, Ferrarese Carlo, Lee Edward B, Shaw Leslie M, Trojanowski John Q, Wolk David A, Grossman Murray: Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiology of aging 63 : 75-87,2017.

View all publications

Academic Contact Info

Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building

Philadelphia, PA 19104-4283
Phone: (215) 662-6399
Patient appointments: 800-789-7366 (PENN)

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