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John Q. Trojanowski, MD, PhD

John Q. Trojanowski, MD, PhD Physician

Director of the Institute on Aging Director, Medical Pathology William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology

Languages spoken:

  • German

Dr. Trojanowski is employed by Penn Medicine.

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  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
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Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1981
  • Pathology - Neuropathology, 1981

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Tufts University School of Medicine
Residency: Mount Auburn Hospital
Residency: Massachusetts General Hospital
Residency: Hospital of the University of Pennsylvania

Memberships

8th International Conference on Progress in Alzheimer's and Parkinson's Disease, International Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, National Alzheimer's Association, Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, International American Academy of Neurology (Consultant, Potamkin Award Subcommittee), American Academy of Neurology (Consultant, Potamkin Award), American Academy of Neurology, American Association of Neuropathologists, American Association of Pathologists, American Board of Pathology, American Brain Tumor Association, American Federation for Aging Research National Scientific Advisory Council , American Health Assistance Foundation Alzheimer's Disease Research Review Committee, American Society for Cell Biology , American Society for Clinical Investigators, American Society for Investigative Pathology, Amyotrophic Lateral Sclerosis Association Grant Review Committee, Association of American Physicians, Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review , National Dystonia Medical Research Foundation, Elwyn Institute, Elwyn, PA, EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), National Harvard Brain Tissue Resource Center, Institute of Medicine Class of 2002, Institute on Aging, International Academy of Pathology, Abstract Review Board member, Killam Research Fellowship Program, The Canada Council, Member, Alzheimer 100 Scientific Advisory Board on the centennial of the presentation by Alois Alzheimer of the Auguste D. case in Tubingen on November 3, 1906, International Member, NINDS Morris K. Udall Parkinson’s Disease Center Coordinating Committee, National MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, National National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, National National Campaign to End Neurological Disorders (END)), National Cancer Institute , National Institute on Aging , National Institute on Aging , National Institute on Aging, National Institute on Aging, Board of Scientific Councilors , National Institute on Aging, National Advisory Council on Aging (NACA), National Institutes of Child Health and Human Development, National Institutes of Health Grant Study Section Reviewers Reserve , National Institutes of Health Neurology A Study Section, National Institutes of Health Pathology A Study Section, National Institutes of Health, National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee , National Institutes of Neurologic Disorders and Stroke, National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, National Sleep Foundation , National Sleep Foundation , Neuroscience Interest Group of the Institute of Medicine, National Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders , National NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, National Organizing Committee, 8th International Conference On Progress In Alzheimer’s And Parkinson’s Disease, Salzburg, Austria , International Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, Society for Neuroscience , Society for Neuroscience, The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, National The Gerontological Society of America (GSA), Task Force on Research Committee, National The Institute for the Study of Aging, University of Pittsburgh Alzheimer’s Disease Research Center, University of Washington Alzheimer's Disease Research Center,

Hospital Affiliation

Dr. Trojanowski is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications:

Mata Ignacio F, Johnson Catherine O, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Van Deerlin Vivianna M, Ritz Beate, Rausch Rebecca, Factor Stewart A, Wood-Siverio Cathy, Quinn Joseph F, Chung Kathryn A, Peterson-Hiller Amie L, Espay Alberto J, Revilla Fredy J, Devoto Johnna, Yearout Dora, Hu Shu-Ching, Cholerton Brenna A, Montine Thomas J, Edwards Karen L: Large-scale exploratory genetic analysis of cognitive impairment in Parkinson's disease. Neurobiology of aging 56 : 211.e1-211.e7,2017.

Irwin D J, Lleó A, Xie S X, McMillan C T, Wolk D, Lee E B, Van Deerlin V M, Shaw L M, Trojanowski J Q: Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD. Annals of neurology : 2017.

McKeith Ian G, Boeve Bradley F, Dickson Dennis W, Halliday Glenda, Taylor John-Paul, Weintraub Daniel, Aarsland Dag, Galvin James, Attems Johannes, Ballard Clive G, Bayston Ashley, Beach Thomas G, Blanc Frédéric, Bohnen Nicolaas, Bonanni Laura, Bras Jose, Brundin Patrik, Burn David, Chen-Plotkin Alice, Duda John E, El-Agnaf Omar, Feldman Howard, Ferman Tanis J, Ffytche Dominic, Fujishiro Hiroshige, Galasko Douglas, Goldman Jennifer G, Gomperts Stephen N, Graff-Radford Neill R, Honig Lawrence S, Iranzo Alex: Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology 89 (1): 88-100,2017.

Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Céline, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert, Hoffmann Per, Grove Megan L, Vardarajan Badri N, Hiltunen Mikko, Nöthen Markus M, White Charles C, Hamilton-Nelson Kara L, Epelbaum Jacques, Maier Wolfgang: Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature genetics : 2017.

Gold Brian T, Brown Christopher A, Hakun Jonathan G, Shaw Leslie M, Trojanowski John Q: Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults. Neurobiology of aging 58 : 102-111,2017.

Henderson Michael X, Chung Charlotte Hiu-Yan, Riddle Dawn M, Zhang Bin, Gathagan Ronald J, Seeholzer Steven H, Trojanowski John Q: Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 (24): 5870-5884,2017.

Cornec Anne-Sophie, Monti Ludovica, Kovalevich Jane, Makani Vishruti, James Michael J, Vijayendran Krishna G, Oukoloff Killian, Yao Yuemang, Lee Virginia M-Y, Trojanowski John Q, Smith Amos B, Brunden Kurt R: Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases. Journal of medicinal chemistry 60 (12): 5120-5145,2017.

Kovacs Gabor G, Xie Sharon X, Lee Edward B, Robinson John L, Caswell Carrie, Irwin David J, Toledo Jon B, Johnson Victoria E, Smith Douglas H, Alafuzoff Irina, Attems Johannes, Bencze Janos, Bieniek Kevin F, Bigio Eileen H, Bodi Istvan, Budka Herbert, Dickson Dennis W, Dugger Brittany N, Duyckaerts Charles, Ferrer Isidro, Forrest Shelley L, Gelpi Ellen, Gentleman Stephen M, Giaccone Giorgio, Grinberg Lea T, Halliday Glenda M, Hatanpaa Kimmo J, Hof Patrick R, Hofer Monika, Hortobágyi Tibor, Ironside James W: Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of neuropathology and experimental neurology : 2017.

Gendron Tania F, Daughrity Lillian M, Heckman Michael G, Diehl Nancy N, Wuu Joanne, Miller Timothy M, Pastor Pau, Trojanowski John Q, Grossman Murray, Berry James D, Hu William T, Ratti Antonia, Benatar Michael, Silani Vincenzo, Glass Jonathan D, Floeter Mary Kay, Jeromin Andreas, Boylan Kevin B: Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis. Annals of neurology : 2017.

Paolicelli Rosa C, Jawaid Ali, Henstridge Christopher M, Valeri Andrea, Merlini Mario, Robinson John L, Lee Edward B, Rose Jamie, Appel Stanley, Lee Virginia M-Y, Trojanowski John Q, Spires-Jones Tara, Schulz Paul E: TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron : 2017.

View all publications

Academic Contact Info

Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building

Philadelphia, PA 19104-4283
Phone: (215) 662-6399
Patient appointments: 800-789-7366 (PENN)

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