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John R. Stanley, MD

John R. Stanley, MD Physician

Emeritus Professor of Dermatology

Dr. Stanley is employed by Penn Medicine.

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About Dr. John R. Stanley

Recognized in Philadelphia Magazine's annual Top Docs issue from 2004 - 2008, and 2010 - 2016

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2014

Recognized by Best Doctors in America 2003 - 2018

Clinical Specialties


  • Dermatology

Programs & Centers:

Board Certification:

  • Dermatology - Clinical and Laboratory Dermatological Immunology, 1985
  • Dermatology, 1978

Clinical Expertise:

  • Dermatitis Herpetiformis (Duhring's Disease)
  • Erythema Multiforme
  • Pemphigus

Practice Locations and Appointments

  • Penn Dermatology Perelman

    Perelman Center for Advanced Medicine South Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard University
Residency: University of Washington Hospitals
Residency: New York University Medical Center
Fellowship: National Institutes of Health


American Academy of Dermatology, National American Dermatological Association, National American Federation for Clinical Research, National American Skin Association, National American Society for Clinical Investigation, National Association of American Physicians, National College of Physicians of Philadelphia, Local Dermatology Foundation, National German Epidermolysis Bullosa Rare Disease Network, International Institute of Medicine of the National Academy of Sciences, National International Pemphigus Foundation, International National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIAMS), National National Institutes of Health, National Philadelphia Dermatological Society, Local Society for Investigative Dermatology, National Uniformed Services University of Health Sciences, National

Hospital Affiliation

Dr. Stanley is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Selected Publications:

Chen J, Zheng Q, Hammers CM, Ellebrecht CT, Mukherjee EM, Tang HY, Lin C, Yuan H, Pan M, Langenhan J, Komorowski L, Siegel DL, Payne AS, Stanley JR: Proteomic analysis of pemphigus autoantibodies indicates a larger, more diverse, and more dynamic repertoire than determined by B-cell genetics Cell Reports 18 : 237-247,2017.

Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Shiraishi K, Shirakata Y, Stanley JR, Ishiko A: Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering J Dermatol Sci 85 : 197-207,2017.

Hammers CM, Stanley JR: Mechanisms of Disease: Pemphigus and bullous pemphigoid. Annual Review of Pathology: Mechanisms of Disease 11 : 175-197,2016.

Hammers CM, Chen J, Lin C, Kacir S, Siegel DL, Payne AS, Stanley JR: Persistence of anti-desmoglein 3 IgG B-cell clones in pemphigus patients over years J. Invest. Dermatol. 135 : 742-749,2015.

Toumi A, Saleh MA, Yamagami J, Abida O, Kallel M, Masmoudi A, Makni S, Turki H, Hachiya T, Kuroda K, Stanley JR, Masmoudi H, Amagai M: Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus J Dermatol Sci 70 (1): 19-25,2013.

Kouno K, Lin C, Schechter N, Siegel D, Yang X, Seykora JT, Stanley JR: Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus monoclonal antibody J Invest Dermatol : 2013.

Hammers CM, Stanley JR: Antibody phage display: Technique and applications J. Invest. Dermatol. 134:e17 (doi:10.1038/jid 2013.521): 2013.

Hammers CM, Stanley JR: Desmoglein-1, differentiation, and disease J. Clin. Invest. Doi:10.1172/JCI69071 : 2013.

Lunardon L, Tsai KJ, Propert KJ, Fett N, Stanley JR, Werth VP, Tsai DE, Payne AS: Adjuvant rituximab therapy of pemphigus: A single center experience with 31 patients Arch Dermatol 148 : 1031-1036,2012.

Yamagami J, Payne AS, Kacir S, Ishii K, Siegel DL, Stanley JR: Homologous regions of heavy chain complementarity determining region 3 (H-CDR3) of pemphigus antibodies cause pathogenicity J Clin Invest 120 : 4111-4117,2010.

Academic Contact Info

University of Pennsylvania School of Medicine
Department of Dermatology
421 Curie Boulevard

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)

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