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John T. Seykora, MD, PhD

John T. Seykora, MD, PhD Physician

Associate Professor of Pathology and Laboratory Medicine Associate Professor of Dermatology

Dr. Seykora is employed by Penn Medicine.

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About Dr. John T. Seykora

Dr. Seykora reads dermatopathology at HUP, but does not schedule appointments with patients.

Clinical Specialties


  • Dermatology

Programs & Centers:

Board Certification:

  • Dermatology - Dermatopathology, 1998
  • Pathology - Anatomic Pathology, 1997

Clinical Expertise:

  • Dermatopathology
  • Immunodermatology
  • Lesions
  • Oral Lesions (Mouth Lesions)
  • Precancerous Lesions
  • Second Opinion
  • Skin Biopsy
  • Skin Cancer

Description of Clinical Expertise

1. Alopecias-including analysis via horizontal sections
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Practice Locations and Appointments

  • Penn Dermatology Perelman

    Perelman Center for Advanced Medicine South Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Weill Medical College of Cornell University
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Academy of Dermatology, National American Dermatological Association, National American Society of Dermatopathology, National Dermatology Foundation, National NIH ACTS/CE/SEP Study Section, National Pennsylvania Regional Society of Dermatopathologists, Local Philadelphia College of Physicians, Local Philadelphia Dermatological Society, Local Signum Pharmaceuticals, Monmouth Junction, New Jersey, National Society of Investigative Dermatology, National Society of Investigative Dermatology, National Southeastern Pennsylvania Regional Society of Dermatopathologists, Local

Hospital Affiliation

Dr. Seykora is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Selected Publications:

Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE.: WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. June 7, 2017; 8; 15397. doi: 10.1028/ncomms15397. PubMed PMID: 28589954; PubMed Central PMCID: PMCID: PMC5467248. : 2017.

Ma S, Imadojemu S, Beer K and Seykora JT.: Inflammatory features of frontal fibrosing alopecia. Journal of Cutaneous Pathology Epub: : 2017.

Ellebrecht, C.T., Bhoj, V.G., Nace, A., Choi, E.J., Mao, X, Cho, M.J.< Di Zenzo, G., Lanzavecchia, A., Seykora, J.T., Cotsarelis, G., Milone, M.C., Payne, A.S.: Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease Science 353 (6295): 179-84,2016.

Gui, J., Gober, M., yang, X, katlinski, K.V., Marshall, C.M., Sharma, M., Werth, V.P., Baker, D.P., Rui, H., Seykora, J.T., Fuchs, S.Y.: Therapeutic elimination of the type I interferon receptor for treating psoriatic sk inflammation Journal of Investigative Dermatology, 2016 Jun 28 : 2016.

Oh, J.W., Kloepper, J., Langan, E.A., Kim, Y., Yeo, J., Kim, M.J.< Hsi, T.C., Rose, C., Yoon, G.S., Lee, S.J., Seykora, J.T., Kim, J.C., Sung, Y.K., Kim, M., Paus, R., Plikus, M.V.: A guide to studying human hair follicle cycling in vivo Journal of Investigative Dermatology 36 (1): 134-44,2016.

Taylor, L.A., ODay, C., Dentchev, T., Hood, K., Chu, E.Y., Ridky, T.W., Seykora, J.T.: p15 expression differentiates nevus from melanoma American Journal of Pathology In Press : 2016.

McNeal, A.S., Liu, K., Nakhate, V., Natale, C.A., Duperret, E.K., Capell, B.C., Dentchev, T., Berger, S.L., Herlyn, M., Seykora, J.T., Ridky, T.W.: CDKN2B loss promotes progression from benign melanocytic nevus to melanoma Cancer Discov 5 (10): 1072-85,2015.

Seykora, J.T., Dentchev, T., Margolis, D.: Fillagrin 2 barrier protein varies inversely with inflammation Experimental Dermatology : 2015.

Ortiz, M.L., Kumar V., Martner, A., Mony S., Donthireddy, L., Condamine, T., Seykora, J., Knight, S.C., Malietzis, G., Lee, G.H., Moorghen, M., Lenox, B., Luetteke, N., Celis, E., Gabrilovich, D.: Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells Journal of Experimental Medicine 2015 Mar 9 212 (3): 351-67,2015.

Sanzari, J.K., Diffendender, E.S., Hagan, S., Billings, P.C., Gridley, D.S., Seykora, J.T., Kennedy, A.R., Cengel, K.A.: Dermatopathology effects of simulated solar particle event radiation exposure in the porcine model Life Sciences in Space Research 6 : 21-28,2015.

Academic Contact Info

Department of Dermatology
421 Curie Blvd
Room 1011 BRB II/III

Philadelphia, PA 19104-6142
Phone: (215) 898-0170
Patient appointments: 800-789-7366 (PENN)