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John T. Seykora, MD, PhD

John T. Seykora, MD, PhD Physician

Associate Professor of Dermatology

Dr. Seykora is employed by Penn Medicine.

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  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients in a medical practice setting.
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About Dr. John T. Seykora

Dr. Seykora reads dermatopathology at HUP, but does not schedule appointments with patients.

Clinical Specialties


  • Dermatology

Programs & Centers:

Board Certification:

  • Dermatology - Dermatopathology, 1998
  • Pathology - Anatomic Pathology, 1997

Clinical Expertise:

  • Acne Surgery
  • Biologic Therapy for Skin Diseases
  • Chemical Peel
  • Cosmetic Laser Eyelid Surgery
  • Cryosurgery of Skin Lesions
  • Dermal Fillers
  • Dermatologic Surgery
  • Dermoscopy
  • Destruction of Benign Skin Lesions
  • Destruction of Premalignant Skin Lesion
  • Electrosurgery for Skin Lesions
  • Excision of Benign Lesions
  • Excision of Malignant Lesions
  • Keloid Scar Removal
  • Laser Skin Rejuvenation
  • Laser Snoring Treatment
  • Laser Spider Vein Treatment
  • Liposuction (Lipoplasty)
  • Liquid Facelift
  • Mole Mapping
  • Port Wine Stain Treatment
  • Sebaceous Cyst Removal
  • Skin Biopsy
  • Skin Cancer Screening
  • Skin Cancer Surgery
  • Skin Examination
  • Skin Patch Tests
  • Skin Resurfacing and Rejuvenation
  • Skin Tag Removal
  • Tumescent Liposuction
  • Wart Removal
Show All Expertise

Practice Locations and Appointments

  • Penn Dermatology Perelman

    Perelman Center for Advanced Medicine South Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Weill Medical College of Cornell University
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Academy of Dermatology, National American Dermatological Association, National American Hair Research Society, International American Society of Dermatopathology, National Dermatology Foundation, National NIH ACTS/CE/SEP Study Section, National Philadelphia College of Physicians, Local Philadelphia Dermatological Society, Local Signum Pharmaceuticals, Monmouth Junction, New Jersey, National Society of Investigative Dermatology, International

Hospital Affiliation

Dr. Seykora is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Selected Publications:

Chandrasekaran S, Sasaki M, Scharer CD, Kissick HT, Patterson DG, Magliocca, KR, Seykora JT, Sapkota B, Gutman DA, Cooper LA, Lesinski GB, Waller EK, Thomas, SN, Kotenko SV, Boss JM, Moreno CS, Swerlick RA, Pollack BP.: “Phosphoinositide 3-kinase signaling can modulate MHC class I and II expression.” Mol Cancer Res. : 2019.

Lee V, Gober MD, Bashir H, O’Day C, Blair IA, Mesaros C, Weng L, Huang A, Chen A, Tang R, Anagnos V, Li JL, Roling S, Sagaityte E, Wang A, Lin C, Yeh C, Atillasoy C, Marshall C, Dentchev T, Ridky T, and Seykora JT.: “Voriconazole enhances UV-induced DNA damage by inhibiting catalase and promoting oxidative stress.” Exp Dermatol : 2019.

Micheletti RG, Chansky PB, Haun PL, Seykora JT, Dekerlegand J, Sultan LR, Schultz SM, Sehgal CM, Sobanko JF: “Ablative fractional laser resurfacing for treatment of sclerosis and contractures in chronic graft-versus-host disease: A pilot study.” J Am Acad Dermatol : 2019.

Ma SA, O'Day CP, Dentchev T, Takeshita J, Ridky TW, Seykora JT, Chu EY: Expression of p15 in a spectrum of spitzoid melanocytic neoplasms J Cutan Pathol 46 (5): 310-16,2019.

Yang X, Daifallah AEM Shankar S, Beer J, Marshall C, Dentchev T, Seykora F, D'Armas S, Hahn J, Lee V, Sabry HH, Farag AM, Seykora JT: Topical kinase inhibitors induce regression of cutaneous squamous cell carcinoma Exp Dermatol 28 (5): 609-13,2019.

Lee V, Yang X, Prouty S, Dentchev T, Marshall C, Maeno H, Bashir H, O'Day C, Seykora JT.: Srcasm regulates tyrosine kinases in skin cancer: Implications for precision medicine. Journal of Investigative Dermatology Symp Proc. 19 (2): S103-S105,2018.

Stewart CL, Cornejo CM, Wanat KA, Sander I, Samimi S, Prouty S, Seykora JT. Zhang P, Rosenbach M, Kim EJ, Micheletti RG.: The immune reconstitution of the skin following sex-mismatched allogeneic haematopoietic stem cell transplant: A prospective case series utilizing fluorescence in situ hybridization and immunohistochemistry. Br J Dermatol. 178 (1): e55-e56,2018.

Dou Z, Ghosh K, Vixioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M. Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.: Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 550 (7676): 402-406,2017.

Ma S, Imadojemu S, Beer K, Seykora JT.: Inflammatory features of frontal fibrosing alopecia. Journal of Cutaneous Pathology 44 (8): 672-676,2017.

Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE.: WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nature Communications 8 : 15397,2017.

Academic Contact Info

Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd

Philadelphia, PA 19104-6142
Phone: (215) 898-0170
Patient appointments: 800-789-7366 (PENN)