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John P. Christodouleas, MD

John P. Christodouleas, MD Physician

Adjunct Assistant Professor of Radiation Oncology

Dr. Christodouleas is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Radiation Oncology

Programs & Centers:

Board Certification:

  • Radiation Oncology, 2010

Clinical Expertise:

  • Bladder Cancer
  • Kidney Cancer
  • Penile Cancer
  • Prostate Cancer
  • Proton Therapy
  • Radiation Treatment
  • Testicular Cancer
  • Urethral Cancer

Description of Clinical Expertise

Dr. Christodouleas is a radiation oncologist who specializes in the treatment of prostate and bladder cancers. His clinical interest is in the use of new diagnostic and therapeutic technologies and how these can be used to improve cancer cure rates and decrease side effects of treatments. He is a nationally recognized authority on the use of image-guided proton therapy and intensity modulated x-ray therapy.

Dr. Christodouleas has written extensively about ways to optimize cancer control and quality of life for patients with cancer and has published primary research, reviews and editorials in a variety of journals including The New England Journal of Medicine, Cancer and The International Journal of Radiation Oncology*Biology*Physics. He has authored over 20 book chapters on the care of cancer patients and is co-editor of one of the leading textbooks in radiation oncology. He has served as the University of Pennsylvania’s Primary Investigator to the Proton Collaborative Group and as a reviewer for the Journal of the National Comprehensive Cancer Center Network, Clinical Cancer Research, The International Journal of Radiation Oncology*Biology*Physics, and Practical Radiation Oncology.

Patient testimonials:

To listen to patient’s talk about their experiences with Dr. Christodouleas and PENN Medicine, follow these links:


Dr. Christodouleas earned a Bachelor of Arts in Mathematics and Philosophy at Swarthmore College. He completed a combined Doctorate in Medicine and Masters of Public Health at Tufts University where he graduated with Research Honors. While at Tufts University, he was honored with The William Dameshek Research Award, The Dolores Zohrab Liebmann Fellowship and the Presidential Award for Citizenship and Public Service. He trained in Radiation Oncology at the Johns Hopkins Hospital.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Amerihealth
  • NJ Medicaid
  • NJ Medicare
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Tufts University School of Medicine
Residency: Lemuel Shattuck Hospital
Residency: Johns Hopkins Hospital


American College of Radiology (ACR), National American Medical Association (AMA), National American Society for Clinical Oncology (ASCO), National American Society of Radiation Oncology (ASTRO), National Proton Collaborative Group, National Radiological Society of North America (RSNA), National

Hospital Affiliation

Dr. Christodouleas is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

bladder cancer, prostate cancer, lung cancer, cancer informatics

Selected Publications:

Christodouleas John P, Forrest Robert D, Ainsley Christopher G, Tochner Zelig, Hahn Stephen M, Glatstein Eli: Short-Term and Long-Term Health Risks of Nuclear-Power-Plant Accidents. The New England journal of medicine 364 (24): 2334-41,2011.

Christodouleas JP, Chang J: Early Stage Non-small Cell Lung Cancer Radiation Oncology: A Question-Based Review : 2010 .

Christodouleas J, Susil RJ, McNutt TR, Song DY, DeWeese TL, Bekelman J, Vapiwala N, Shinkle B, Lu H, Both S: The impact of a rectal-prostate spacer on proton radiation of the prostate: a planning study ASTRO Annual Meeting : 2010.

Christodouleas JP, DeWeese TL: Intermediate and High Risk Prostate Cancer Radiation Oncology: A Question-Based Review : 2010.

Christodouleas JP, Hahn SM: The need for and future of clinical trials of proton therapy Radiation Medicine Rounds 1 (3): 455-469,2010.

Marks Lawrence B, Saynak Mert, Christodouleas John P: Stage III vs. stage IV lung cancer: "Crossing a Great Divide". Lung cancer (Amsterdam, Netherlands) 67 (1): 1-3,2010.

Christodouleas John P, Marks Lawrence B: Analysis of patients with oligometastases undergoing two or more curative-intent stereotactic radiotherapy courses: in regard to Milano et al. (Int J Radiat Oncol Biol Phys 2009;73:832-837). International journal of radiation oncology, biology, physics 74 (5): 1628; author reply 1628-9,2009.

Christodouleas J, Fox J, DeWeese T, Song D: Radiation Therapy for Prostate Cancer Early Diagnosis of Cancer: Prostate Cancer : 2009.

Christodouleas J, Yeater D, Jabbour S, Leman ES, Mangold L, R Drew, Humphreys E, Partin A, Getzenberg R, DeWeese T: Modulation of EPCA-2 levels in men with localized prostate cancer treated with radiation with or without hormonal therapy ASTRO : 2008.

Zietman Anthony L, Christodouleas John P, Shipley William U: PSA bounces after neoadjuvant androgen deprivation and external beam radiation: impact on definitions of failure. International journal of radiation oncology, biology, physics 62 (3): 714-8,2005.

Academic Contact Info

Department of Radiation Oncology
Hospital of the University of Pennsylvania
Administrative Offices
The Perelman Center for Advanced Medicine
3400 Civic Center Blvd.
TRC-2 West

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)

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