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Joel S. Bennett, MD

Joel S. Bennett, MD Physician

Professor of Pharmacology Professor of Medicine

Dr. Bennett is employed by Penn Medicine.

About Dr. Joel S. Bennett

Recognized by Best Doctors in America 2005 - 2018

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties

Specialty:

  • Hematology

Programs & Centers:

Board Certification:

  • Hematology, 1974
  • Internal Medicine, 1974

Clinical Expertise:

  • Bleeding Disorders

Description of Clinical Expertise

General Hematology, Internal Medicine, Hemostasis, and Thrombosis

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Michigan
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Federation for Clinical Research, National American Heart Association, National American Society for Biochemistry and Molecular Biology, National American Society for Clinical Investigation, National American Society of Hematology, National Association of American Physicians, National International Society on Thrombosis and Haemostasis, International John Morgan Society, Local National Institutes of Health, National Philadelphia Hematology Society, Local Veterans Administration Hospital, Philadelphia, PA, Local

Hospital Affiliation

Dr. Bennett is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Integrin function is essential for normal platelet adhesion and aggregation and participates i n the formation of the arterial thrombi that are responsible for heart attacks and strokes. The activation state of platelet integrins is regulated by platelet agonists, but the structural basis for this regulation is not known. Our studies indicate that helix-helix interactions involving the transmembrane and membrane-proximal cytoplasmic domain segments play an essential role in regulating the function of both beta 1 and beta 3 integrins. The current focus of the laboratory is to use biophysical and molecular biologic techniques to characterize these interactions in detail and to use this information to design potential anti-thrombotic agents.

Selected Publications:

Mravic, M., Hu, H., Lu, Z., Bennett, J.S., Sanders, C.R., Orr, A.W., and DeGrado, W.F.: De novo designed transmembrane peptides activating the 51 integrin. Protein: De novo designed transmembrane peptides activating the 51 integrin. Protein Engineering, Design & Selection. : 2018.

Bennett, J.S.: Are anti-platelet agents beneficial in Essential Thrombocythemia? Maybe yes, probably no. Ann. Int. Med. 167 : 206-207,2017.

Bennett, J.S.: Clinical dilemma: Experts make the call. ASH Clinical News. 3 (05): 34,2017.

Bennett, J.S.: IIb3 (GPIIb/IIIa) structure and function Platelets in Thrombotic and Non-Thrombotic Disorders 2 : 99-109,2017.

Höök, P., Litvinov, R.I., Kim, O.V., Xu, S., Bennett, J.S., Alber, M.S., and Weisel, J.W: Strong binding of platelet integrin IIb3 to fibrin clots: Potential target to destabilize thrombi. Scientific Reports 7 : 2017.

Kononova, O., Litvinov, R.I., Blokhin, D.S., Klochkov, V.V., Weisel, J.W., Bennett, J.S., Barsegov, V.: Mechanistic basis for the binding of RGD- and AGDV-peptides to the platelet integrin IIb3. Biochemistery 56 : 2017.

Fong, F.P., Zhu, H., Span, L.M., Moore, D.T., Yoon, K., Tamura, R., Yin, H.H., DeGrado, W.F., and Bennett, J.S.: Directly activating IIb3 initiates outside-in signaling by causing IIb3 clustering J. Bio. Chem/ 291 : 2016.

Abrams, C.S., Shattil, S.J., and Bennett, J.S.: Acquired qualitative platelet disorders due to drugs, diseases, and foods Hematology 9 : 2016.

Litvinov, R.I., Farrell, D.H., Weisel, J.W., and Bennett, J.S.: The platelet integrin IIb3 differentially interacts with fibrin versus fibrinogen. J. Biol. Chem. 291 : 2016.

Bennett, J.S.: Editorial: Shedding new light on the platelet storage lesion. Arterioscler. Thromb. Vasc. Biol. 36 : 1715-1716,2016.

View all publications

Academic Contact Info

Division of Hematology-Oncology
814 BRB II/III
421 Curie Boulevard/6160

Philadelphia, PA 19104
Phone: (215) 573-3280
Patient appointments: 800-789-7366 (PENN)

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