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Joel S. Bennett, MD Physician

Professor of Pharmacology Professor of Medicine

Dr. Bennett is employed by Penn Medicine.

About Dr. Joel S. Bennett

Recognized by Best Doctors in America 2005 - 2018

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Hematology

Programs & Centers:

Board Certification:

  • Hematology, 1974
  • Internal Medicine, 1974

Clinical Expertise:

  • Anemia
  • Anemia and Bone Marrow Disorders
  • Anemia of Chronic Disease
  • Anemia of Pregnancy
  • Anticoagulation
  • Antiphospholipid Syndrome
  • Antithrombin Deficiency
  • Aplastic Anemia
  • Autoimmune Hemolytic Anemia
  • B12 Deficiency Anemia
  • Blood Clot
  • Blood Clotting Disorders (Blood Coagulation)
  • Blood Disorders
  • Blood Platelet Disorders
  • Bone Marrow Biopsy
  • Bone Marrow Failure Syndromes
  • Catastrophic Antiphospholipid Syndrome
  • Coagulation Disorders
  • Cold Agglutinin Disease
  • Cooley's Anemia
  • Cryoglobulinemia
  • Deep Thrombophlebitis
  • Deep Vein Thrombosis
  • Diamond Blackfan Anemia
  • Dyskeratosis Congenita
  • Eosinophilic Granuloma
  • Essential Thrombocytosis
  • Factor Eight Disorder
  • Factor Nine Deficiency
  • Factor V Leiden
  • Familial Aplastic Anemia
  • Fanconi Anemia
  • Folic Acid Deficiency
  • Glucose-6-Phosphate Dehydrogenase Deficiency
  • Hand-Foot Syndrome
  • HELLP Syndrome
  • Hemochromatosis
  • Hemoglobinopathies
  • Hemolytic Anemia
  • Hemolytic Uremic Syndrome
  • Hemophilia
  • Heparin-Induced Thrombocytopenia
  • Hereditary Spherocytosis
  • Histiocytosis
  • Hypercoagulable State
  • Hypogammaglobulinemia
  • Idiopathic Thrombocytopenic Purpura
  • Iron Deficiency Anemia
  • Iron Metabolism Disorders
  • Leukocytosis
  • Leukopenia
  • Lupus Anticoagulant
  • Lymphopenia
  • Maternal Anticoagulation
  • Maternal Hematologic Disorders
  • Maternal Thrombophilia
  • Monoclonal Gammopathy of Undetermined Significance
  • Myeloproliferative Neoplasms (MPN)
  • Neutropenia
  • Pancytopenia
  • Paroxysmal Nocturnal Hemoglobinuria
  • Partial Thromboplastin Time Blood Test
  • Pernicious Anemia
  • Petechiae
  • POEMS Syndrome
  • Polycythemia
  • Porphyria
  • Postthrombotic Syndrome
  • Primary Myelofibrosis
  • Primary Systemic Amyloidosis
  • Protein C Deficiency
  • Protein S Deficiency
  • Prothrombin Gene Mutation
  • Pure Red Cell Aplasia
  • Purpura
  • Recurrent Thrombosis
  • Red Blood Cell Disorders
  • Secondary Polycythemia
  • Sickle Cell Diseases
  • Splenic Sequestration
  • Splenomegaly
  • Thalassemias
  • Thrombocytopenia
  • Thrombocytosis
  • Thrombophilia
  • Thrombotic Disorders
  • Thrombotic Thrombocytopenic Purpura
  • Venous-Occlusive Crisis
  • Von Willebrand Disease
  • White Blood Cell Disorders
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Michigan
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Federation for Clinical Research, National American Heart Association, National American Society for Biochemistry and Molecular Biology, National American Society for Clinical Investigation, National American Society of Hematology, National Association of American Physicians, National International Society on Thrombosis and Haemostasis, International John Morgan Society, Local National Institutes of Health, National Philadelphia Hematology Society, Local Veterans Administration Hospital, Philadelphia, PA, Local

Hospital Affiliation

Dr. Bennett is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Integrin function is essential for normal platelet adhesion and aggregation and participates i n the formation of the arterial thrombi that are responsible for heart attacks and strokes. The activation state of platelet integrins is regulated by platelet agonists, but the structural basis for this regulation is not known. Our studies indicate that helix-helix interactions involving the transmembrane and membrane-proximal cytoplasmic domain segments play an essential role in regulating the function of both beta 1 and beta 3 integrins. The current focus of the laboratory is to use biophysical and molecular biologic techniques to characterize these interactions in detail and to use this information to design potential anti-thrombotic agents.

Selected Publications:

Litvinov, R.I., Mravic, M., Zhu, H., Weisel, J.W., DeGrado, W.F., and Bennett, J.S.: Unique transmembrane domain interactions differentially modulate integrin avb3 and aIIbb3 function. Proc. Natl. Acad. Sci. U.S.A. 116 : 11195-12300,2019.

Tan, S.K., Fong, K.P., Polizzi, N.F., Sternisha, A., Slusky, J.S.G., Yoon, K., DeGrado, W.F., and Bennett, J.S.: Modulating integrin aIIbb3 activity through mutagenesis of allosterically regulated inter-subunit contacts Biochemistry 58 : 3251-3259,2019.

Mravic, M., Hu, H., Lu, Z., Bennett, J.S., Sanders, C.R., Orr, A.W., and DeGrado, W.F.: De novo designed transmembrane peptides activating the 51 integrin. Protein: De novo designed transmembrane peptides activating the 51 integrin. Protein Engineering, Design & Selection. : 2018.

Kononova, O., Litvinov, R.I., Blokhin, D.S., Klochkov, V.V., Weisel, J.W., Bennett, J.S., Barsegov, V.: Mechanistic basis for the binding of RGD- and AGDV-peptides to the platelet integrin IIb3. Biochemistery 56 : 2017.

Bennett, J.S.: Are anti-platelet agents beneficial in Essential Thrombocythemia? Maybe yes, probably no. Ann. Int. Med. 167 : 206-207,2017.

Bennett, J.S.: Clinical dilemma: Experts make the call. ASH Clinical News. 3 (05): 34,2017.

Bennett, J.S.: IIb3 (GPIIb/IIIa) structure and function Platelets in Thrombotic and Non-Thrombotic Disorders 2 : 99-109,2017.

Höök, P., Litvinov, R.I., Kim, O.V., Xu, S., Bennett, J.S., Alber, M.S., and Weisel, J.W: Strong binding of platelet integrin IIb3 to fibrin clots: Potential target to destabilize thrombi. Scientific Reports 7 : 2017.

Huntington, S.F., O’Hara, M.O., and Bennett, J.S: Platelet disorders: clinical and laboratory evaluation. Non-Malignant Hematology: Expert Clinical Perspective : 171-184,2016.

Fong, F.P., Zhu, H., Span, L.M., Moore, D.T., Yoon, K., Tamura, R., Yin, H.H., DeGrado, W.F., and Bennett, J.S.: Directly activating IIb3 initiates outside-in signaling by causing IIb3 clustering J. Bio. Chem/ 291 : 2016.

View all publications

Academic Contact Info

Division of Hematology-Oncology
421 Curie Boulevard/6160

Philadelphia, PA 19104
Phone: (215) 573-3280
Patient appointments: 800-789-7366 (PENN)

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