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Jennifer L. Orthmann Murphy, MD, PhD

Jennifer L. Orthmann Murphy, MD, PhD Physician

Co-Director of the Age Span Fellowship in Multiple Sclerosis/Neuroinflammatory Disorders Assistant Professor of Neurology

Dr. Orthmann Murphy is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 2014

Clinical Expertise:

  • Demyelinating Disease
  • Multiple Sclerosis (MS)
  • Myelitis
  • Neurogenetics
  • Neuroinflammatory Disorders
  • Neuromyelitis Optica

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Johns Hopkins Hospital

Memberships

Member, American Academy of Neurology, National Member, American Neurological Association, National Member, National Multiple Sclerosis Society, National Member, Society for Neuroscience, National

Hospital Affiliation

Dr. Orthmann Murphy is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.

Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination

Techniques: multiphoton imaging

Selected Publications:

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi PA, Bergles DE: Oligodendrogenesis following cortical demyelination generates a novel myelination pattern Platform Presentation at the American Academy of Neurology 71st Annual Meeting in Philadelphia, PA : 2019.

Mu W, Schiess N, Orthmann-Murphy JL, El-Hattab AW.: The utility of whole exome sequencing in diagnosing neurological disorders in adults from a highly consanguineous population. J Neurogenet : 10.1080/01677063.2018.1555249,2019.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE.: Remyelination of specific axonal domains in the somatosensory cortex. Poster presentation at the American Neurological Association in Atlanta, GA : 2018.

Hughes EG*, Orthmann-Murphy JL*, Langseth AJ, Bergles DE: Myelin remodeling through experience dependent oligodendrogenesis in the adult somatosensory cortex. Nature Neuroscience 21 (5): 696-706,2018.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE.: Remyelination of specific axonal domains in the somatosensory cortex. Late-Breaking Topic in Myelin Disease: Mechanisms and Treatments session. Poster and Platform Presentation at the Myelin Gordon Research Conference in Ventura, CA. : 2018.

Nahhas N, Conant A, Orthmann-Murphy J, et al.: Pelizaeus-Merzbacher-Like Disease 1. In: Adam MP, Ardinger HH, Pagon RA, et al., : 2017.

Al Dhaibani MA, El-Hattab AW, Holroyd KB, Orthmann-Murphy J, Larson VA, Siddiqui KA, Szolics M, Schiess N: Novel mutation in the KCNJ10 gene in three siblings with seizures, ataxia and no electrolyte abnormalities. J Neurogenet : 1-5,2017.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE: Remyelination of specific axonal domains in the somatosensory cortex. Dynamic Poster presentation at Society for Neuroscience in Washington, DC : 2017.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi PA, Bergles DE: Remyelination of the mouse somatosensory cortex defined by longitudinal two photon in vivo imaging. Poster presentation at National MS Society Tykeson Fellows Conference in Denver, CO : 2017.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE: Remyelination of specific axonal domains in the somatosensory cortex. Poster presentation at Johns Hopkins School of Medicine Department of Neuroscience Annual Retreat in Cambridge, MD : 2017.

Academic Contact Info

Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3606
Patient appointments: 800-789-7366 (PENN)