Description of Research Expertise
Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.
Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination
Techniques: multiphoton imaging
Selected Publications
Jennifer L. Orthmann-Murphy: An Undiagnosed White Matter Disorders Neurogenetics Clinic ACTRIMS Virtual Meeting 2020 Poster P100 : 2021.
Jennifer Orthmann-Murphy*, Cody L Call*, Gian C Molina-Castro, Yu Chen Hsieh, Matthew N Rasband, Peter A Calabresi, Dwight E Bergles. *Co-first authors: Remyelination alters the pattern of myelin in the cerebral cortex eLife : 2020.
Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi PA, Bergles DE: Oligodendrogenesis following cortical demyelination generates a novel myelination pattern Platform Presentation at the American Academy of Neurology 71st Annual Meeting in Philadelphia, PA : 2019.
Mu W, Schiess N, Orthmann-Murphy JL, El-Hattab AW.: The utility of whole exome sequencing in diagnosing neurological disorders in adults from a highly consanguineous population. J Neurogenet : 10.1080/01677063.2018.1555249,2019.
Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE.: Remyelination of specific axonal domains in the somatosensory cortex. Poster presentation at the American Neurological Association in Atlanta, GA : 2018.
Hughes EG*, Orthmann-Murphy JL*, Langseth AJ, Bergles DE: Myelin remodeling through experience dependent oligodendrogenesis in the adult somatosensory cortex. Nature Neuroscience 21 (5): 696-706,2018.
Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE.: Remyelination of specific axonal domains in the somatosensory cortex. Late-Breaking Topic in Myelin Disease: Mechanisms and Treatments session. Poster and Platform Presentation at the Myelin Gordon Research Conference in Ventura, CA. : 2018.
Nahhas N, Conant A, Orthmann-Murphy J, et al.: Pelizaeus-Merzbacher-Like Disease 1. In: Adam MP, Ardinger HH, Pagon RA, et al., : 2017.
Al Dhaibani MA, El-Hattab AW, Holroyd KB, Orthmann-Murphy J, Larson VA, Siddiqui KA, Szolics M, Schiess N: Novel mutation in the KCNJ10 gene in three siblings with seizures, ataxia and no electrolyte abnormalities. J Neurogenet : 1-5,2017.
Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi PA, Bergles DE: Remyelination of the mouse somatosensory cortex defined by longitudinal two photon in vivo imaging. Poster presentation at National MS Society Tykeson Fellows Conference in Denver, CO : 2017.
Academic Contact Information
Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia,
PA
19104
Phone: 215-662-3606
Patient appointments: 800-789-7366