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James K. Mangan, MD, PhD

James K. Mangan, MD, PhD Physician

Assistant Professor of Clinical Medicine

Languages spoken:

  • Spanish

Dr. Mangan is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Hematology
  • Medical Oncology

Programs & Centers:

Board Certification:

  • Hematology, 2011
  • Internal Medicine, 2008

Clinical Expertise:

  • Acute Leukemia
  • Aplastic Anemia
  • Bone Marrow Transplant
  • Chronic Myeloid Leukemia (CML)
  • Leukemia
  • Myelodysplastic Syndromes (MDS)
  • Myeloproliferative Neoplasms (MPN)

Description of Clinical Expertise

Acute Leukemia
Myelodysplastic Syndrome
Myeloproliferative Neoplasms
Chronic Myeloid Leukemia
Aplastic Anemia
Allogeneic Stem Cell Transplant

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Temple University School of Medicine
Residency: University of Michigan Medical Center
Fellowship: Hospital of the University of Pennsylvania


American Society for Blood and Marrow Transplantation, National American Society of Hematology, National

Hospital Affiliation

Dr. Mangan is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Acute Leukemia, novel therapies
Myelodysplastic syndromes, novel therapies
Myeloproliferative neoplasms, novel therapies

Selected Publications:

Ganetsky A, Frey NV, Hexner EO, Loren AW, Gill SI, Luger SM, Mangan JK, Martin ME, Babushok DV, Drobyski WR, Smith J, Timlin C, Freyer CW, Stadtmauer EA, and Porter DL.: Tocilizumab for severe steroid-refractory acute graft-versus-host-disease of the lower gastrointestinal tract. Bone Marrow Transplantation : epub ahead of print,2018.

Kasner MT, Mick R, Jeschke GR, Carabasi M, Filicko-O'Hara J, Flomenberg N, Frey NV, Hexner EO, Luger SM, Loren AW, Mangan JK, Wagner JL, Weiss M, Carroll M, Perl AE.: Sirolimus enhances remission induction in patients with high risk acute myeloid leukemia and mTORC1 target inhibition. Invest New Drugs epub ahead of print : 2018.

Hogan JJ, Loren AW, Denker MG, Mangan JK: Edema with hypoalbuminemia as a rare manifestation of chronic graft versus host disease after allogeneic hematopoietic cell transplant. Leukemia and Lymphoma 58 (8): 2008-2010,2017.

Mesa RA, Miller CB, Thyne M, Mangan J, Goldberger S, Fazal S, Ma X, Wilson W, Paranagama DC, Dubinski DG, Naim A, Parasuraman S, Boyle J, Mascarenhas JO: Differences in treatment goals and perception of symptom burden between patients with myeloproliferative neoplasms (MPNs) and hematologists/oncologists in the United States: Findings from the MPN Landmark Survey. Cancer 123 (3): 449-458,2017.

Yam C, Crisalli L, Luger SM, Loren AW, Hexner EO, Frey NV, Mangan JK, Gao A, Stadtmauer EA, Porter DL, Reshef R.: Unrelated donors are associated with improved relapse-free survival compared to related donors in patients with myelodysplastic syndrome undergoing reduced intensity allogeneic stem cell transplantation. American Journal of Hematology 91 (9): 883-887,2016.

Frey NV, Shaw PA, Hexner EO, Gill S, Marcucci, K, Luger SM, Mangan JK, Grupp SA, Maude SL, Ericson S, Levine BL, Lacey SF, Melehorst JJ, June CH, Porter DL: Optimizing chimeric antigen receptor (CAR) T cell therapy for adult patients with relapsed or refractory (r/r) acute lymphoblastic leukemia American Society of Clinical Oncology Annual Meeting, Chicago, IL (166823): 2016.

Mangan JK, Chmieliauskaite M, Stoopler ET.: An intraoral mass associated with myelodysplastic syndrome. JAMA Oncology 2 (5): 679-680,2016.

Hexner EO, Luger SM, Reshef R, Jeschke GR, Mangan JK, Frey NV, Frank DM, Richman LP, Vonderheide RH, Aqui NA, Rosenbach M, Zhang Y, Chew A, Loren AW, Stadtmauer EA, Levine BL, June CH, Emerson SG, Porter DL.: Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment. American Journal of Hematology 91 (5): 453-460,2016.

Mesa R, Miller CB, Thyne M, Mangan J, Goldberger S, Fazal S, Ma X, Wilson W, Paranagama DC, Dubinski DG, Boyle J, Mascarenhas JO: Myeloproliferative neoplasms (MPNs) have a significant impact on patients' overall health and productivity: the MPN Landmark Survey. BMC Cancer 16 (167): 2016.

Ganetsky A, Crisalli LM, Huffman AP, Acosta EP, Mangan JK, Luger SM, Loren AW, Hexner EO, Frey NV, Stadtmauer EA, Hoxie JA, Vonderheide RH, Porter DL, Reshef R.: Maraviroc concentrations are highly predictive of acute graft-versus-host-disease in reduced-intensity allogeneic stem cell transplantation. European Hematology Association Annual Meeting, Copenhagen, Denmark (331): 2016.

Academic Contact Info

Division of Hematology Oncology
Perelman Center for Advanced Medicine
12th Floor, South Pavilion
Office #12-155
34th Street and Civic Center Blvd

Philadelphia, PA 19104
Phone: (215) 615-3138
Patient appointments: 800-789-7366 (PENN)