Description of Research Expertise:
My role as an advanced heart failure clinician-scientist and system director of Mechanical Circulatory Support at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. With all of the patients that seek a first or second opinion from my clinic, the primary aim is to find pathways and therapeutic approaches to recover the failing heart. For the last ten years, I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Kieran Clarke from Oxford University, Dr. Daniel Kelly, Dr. Ken Margulies, and Dr. Tom Cappola within the Cardiovascular Institute at Penn. We are currently conducting the first in human study of oral ketone ester therapy to induce a nutritional ketosis in ambulatory, NYHA Class III Heart Failure.
Kim Yuli Y, Awh Katherine, Acker Michael, Atluri Pavan, Bermudez Christian, Crespo Maria, Diamond Joshua M, Drajpuch David, Forde-Mclean Rhondalyn, Fuller Stephanie, Goldberg Lee, Mazurek Jeremy, Mascio Christopher, Menachem Jonathan N, Rame Eduardo, Ruckdeschel Emily, Tobin Lynda, Wald Joyce: Pulmonary arterial hypertension in adults with systemic right ventricles referred for cardiac transplantation. Clinical transplantation 33 (4): e13496,2019.
Brown Chase R, Khurshan Fabliha, Chen Zehang, Groeneveld Peter W, McCarthy Fenton, Acker Michael, Rame J Eduardo, Desai Nimesh: Optimal timing for heart transplantation in patients bridged with left ventricular assist devices: Is timing of the essence? The Journal of thoracic and cardiovascular surgery : 2019.
Chung Jennifer J, Stetson Robert, Gordon Jonathan, Chen Carol W, Gaffey Ann C, Rame Jesus Eduardo, Acker Michael, Atluri Pavan: Better With Time: An Economic Assessment of Long-Term Mechanical Circulatory Support in a Population Surviving at Least 1 Year with a Left Ventricular Assist Device. Seminars in thoracic and cardiovascular surgery : 2018.
Reza Nosheen, Chowns Jessica L, Merrill Shana L, Marzolf Amy, Zado Erica S, Palmer Matthew B, Deshpande Charuhas, Pryma Daniel A, Rame J Eduardo, Marchlinski Francis E, Owens Anjali Tiku: Frameshifts in Code and in Care: The Importance of Timely Genetic Evaluation. Circulation. Genomic and precision medicine 11 (5): e002215,2018.
Menachem Jonathan N, Birati Edo Y, Zamani Payman, Owens Anjali T, Atluri Pavan, Bermudez Christian A, Drajpuch David, Fuller Stephanie, Kim Yuli Y, Mascio Christopher E, Palanivel Vikram, Rame J Eduardo, Wald Joyce, Acker Michael A, Mazurek Jeremy A: Pulmonary hypertension: Barrier or just a bump in the road in transplanting adults with congenital heart disease. Congenital heart disease 13 (4): 492-498,2018.
Birati Edo Y, Hanff Thomas C, Maldonado Dawn, Grandin E Wilson, Kennel Peter J, Mazurek Jeremy A, Vorovich Esther, Seigerman Matthew, Howard Jessica L L, Acker Michael A, Naka Yoshifumi, Wald Joyce, Goldberg Lee R, Jessup Mariell, Atluri Pavan, Margulies Kenneth B, Schulze P Christian, Rame J Eduardo: Predicting Long Term Outcome in Patients Treated With Continuous Flow Left Ventricular Assist Device: The Penn-Columbia Risk Score. Journal of the American Heart Association 7 (6): 2018.
Jason J. Han MD, Salman Zaheer MD, Rahul Kanade BA, Jennifer Chung MD, Carol W Chen MD, Ann C Gaffey MD, Christyna Justice RN, BSN, Alyse E Ameer BS, J. Eduardo Rame MD, Michael A. Acker MD, Pavan Atluri MD: Left Ventricular Assist Device Implantation Reduces Elevated Pulmonary Vascular Resistance in Patients Bridged to Heart Transplant Circulation Journal Epub ahead of Print : 2018.
Edo Y. Birati, MD, Thomas C. Hanff, MD, Dawn Maldonado, MD, E. Wilson, Grandin, MD, Peter J. Kennel, MD, Jeremy A. Mazurek, MD, Esther Vorovich, MD, Matthew Seigerman, MD, Jessica LL Howard, BS, Michael A. Acker, MD, Yoshifumi Naka, MD, Joyce Wald, DO, Lee R. Goldberg, MD MPH, Mariell Jessup, MD, Pavan Atluri, MD, Kenneth B. Margulies, MD, P. Christian Schulze, MD and J. Eduardo Rame, MD MPhil1: Predicting Long Term Outcome in patients treated with Continuous Flow Left Ventricular Assist Device - The Penn - Columbia Risk Score Journal of the American Heart Association Epub ahead of Print : 2018.
J.Eduardo Rame and Robert Kormos: Adverse Events and Mitigation Strategies, Mechanical Circulatory Support Braunwald's Mechanical Circulatory Support : 2018.
Gopal Dipika J, Hanff Thomas C, Mazurek Jeremy A, Grandin Wilson E, Howard Jessica, Forde-McLean Rhondalyn, Wald Joyce, King Kathie, Acker Michael A, Goldberg Lee R, Jessup Mariell, Atluri Pavan, Margulies Kenneth B, Rame Eduardo J, Birati Edo Y: Prognostic Implications of Changes in Albumin Following Left Ventricular Assist Device Implantation in Patients With Severe Heart Failure. The American journal of cardiology 120 (11): 2003-2007,2017.