Description of Research Expertise
My laboratory investigates the regulation of normal and malignant hematopoiesis, bone marrow transplantation and T cell alloimmunity. A central focus of our studies is the role of Notch signaling in T cell development, differentiation and function. Using mouse models of bone marrow transplantation, we discovered essential functions for Notch receptors and ligands in graft-versus-host disease with a high fundamental and translational impact. We are also interested to understand the role of fibroblastic reticular cells as a source of Notch ligands and other signals in secondary lymphoid organs, with a focus on their emerging roles in immune regulation as well as in immunological and hematological disorders.
Academic Contact Information
Biomedical Research Building
421 Curie Blvd
4th Floor Rm 451
Philadelphia,
PA
19104
Phone: 215-746-2929