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Issam A. Mardini, MD, PhD Physician

Assistant Professor of Clinical Anesthesiology and Critical Care

Languages spoken:

  • Arabic

Dr. Mardini is employed by Penn Medicine.

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Clinical Specialties


  • Anesthesiology

Programs & Centers:

Board Certification:

  • Anesthesiology - Pain Medicine, 2000
  • Anesthesiology, 1999
  • Hospice and Palliative Medicine, 2012

Clinical Expertise:

  • Opioid-Sparing Anesthesia
  • Pain
  • Peri-Operative Medicine
  • Preoperative Evaluation
  • Regional Anesthesia

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Capital Blue Cross
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Damascus University
Residency: University of Damascus Hospital
Residency: Temple University Hospital
Fellowship: Hospital of the University of Pennsylvania


American Physiological Society, National American Society of Anesthesiologists, National American Society of Regional Anesthesia, National International Anesthesia Research Society, International International Association for the Study of Pain, International Pennsylvania Society of Anesthesiologists, Local

Hospital Affiliation

Dr. Mardini is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Anti-inflammatory drugs, cyclooxygenases ,prostaglandins, mechanisms of pain

Selected Publications:

Barnett RE, Fish D, Katragadda R, Mardini IA, O'Grady TJ: A preemptive approach to stop postoperative pain. A symposium Contemporary Surgery 59 (12) : 559-566,2003.

Aksoy MO, Mardini IA, Yang Y, Bin W, Zhou S, Kelsen SG: Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system of human airway epithelium. The Journal of Allergy and Clinical Immunology 109 (3): 491-7,2002.

McAdam BF, Mardini IA, Habib A, Burke A, Lawson JA, Kapoor S, FitzGerald GA: Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. The Journal of Clinical Investigation 105 (10): 1473-82,2000.

McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA: Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proceedings of the National Academy of Sciences of the United States of America 96 (1): 272-7,1999.

Kelsen SG, Higgins NC, Zhou S, Mardini IA, Benovic JL: Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. American Journal of Respiratory and Critical Care Medicine 152 (6 Pt 1): 1774-83,1995.

Kelsen SG, Zhou S, Anakwe O, Mardini IA, Higgins N, Benovic JL: Expression of the beta-adrenergic receptor-adenylyl cyclase system in basal and columnar airway epithelial cells. The American Journal of Physiology 267 (4 Pt 1): L456-63,1994.

Mardini IA, Higgins NC, Zhou S, Benovic JL, Kelsen SG: Functional behavior of the beta-adrenergic receptor-adenylyl cyclase system in rabbit airway epithelium. American Journal of Respiratory Cell and Molecular Biology 11 (3): 287-95,1994.

Kelsen SG, Sexauer WP, Mardini IA, Criner GJ: The comparative effects of elastase-induced emphysema on costal and crural diaphragm and parasternal intercostal muscle contractility. American Journal of Respiratory and Critical Care Medicine 149 (1): 168-73,1994.

Kelsen SG, Bao S, Thomas AJ, Mardini IA, Criner GJ: Structure of parasternal intercostal muscles in the adult hamster: topographic effects. Journal of Applied Physiology (Bethesda, Md.: 1985) 75 (3): 1150-4,1993.

Kelsen SG, Mardini IA, Zhou S, Benovic JL, Higgins NC: A technique to harvest viable tracheobronchial epithelial cells from living human donors. American Journal of Respiratory Cell and Molecular Biology 7 (1): 66-72,1992.

Academic Contact Info

Department of Anesthesiology and Critical Care
Penn Presbyterian Medical Center

Philadelphia, PA 19104
Phone: (610) 416-4145
Patient appointments: 800-789-7366 (PENN)

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