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Issam A. Mardini, MD, PhD

Issam A. Mardini, MD, PhD Physician

Assistant Professor of Clinical Anesthesiology and Critical Care

Languages spoken:

  • Arabic

Dr. Mardini is employed by Penn Medicine.

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  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
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Clinical Specialties


  • Anesthesiology

Programs & Centers:

Board Certification:

  • Anesthesiology - Pain Medicine, 2000
  • Anesthesiology, 1999
  • Hospice and Palliative Medicine, 2012

Clinical Expertise:

  • Acupuncture Pain
  • Ankle Pain
  • Back Pain
  • BOTOX Therapy
  • Cancer Pain Management
  • Cervical Radiculopathy (Pinched Nerve)
  • Diabetic Kidney Diseases
  • Diabetic Neuropathy
  • Facial Pain
  • Finger Numbness
  • Fluoroscopy Guided Injection
  • Foot Pain
  • Hand Pain
  • Heel Pain
  • Herniated Disc Pain
  • Hip Pain
  • Knee Pain
  • Leg Pain
  • Motor Point Blocks
  • Musculoskeletal Pain
  • Neck Pain
  • Nerve Blocks
  • Neuritis
  • Neuropathic Pain
  • Non-Operative Ankle Injury
  • Non-Operative Scoliosis Treatment
  • Pain - Non-Pharmacological Treatment
  • Pain Management
  • Palliative Care
  • Peripheral Nerve Disease
  • Peripheral Neuropathy
  • Sciatica
  • Scoliosis
  • Sensory Neuropathy
  • Spinal Disc Degeneration
  • Spinal Stenosis
  • Spine Disease
  • Spine Pain
  • Spondyloarthropathy (Spondyloarthritis)
  • Spondylolisthesis
  • Spondylosis
  • Thoracic Pain
  • Trigger Point Joint Injections
  • Undiagnosed Back Pain and Leg Pain
  • Undiagnosed Neck Pain

Description of Clinical Expertise

Acute pain management, perioperative pain control, chronic pain medicine, nerve blocks and regional anesthesia, injection/ablation for chronic pain, anesthesia for orthopedic and gynecological surgery,anesthesia for urological surgery, anticoagulation agents in the perioperative period and their interactions with regional anesthesia.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Capital Blue Cross
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Damascus University
Residency: University of Damascus Hospital
Residency: Temple University Hospital
Fellowship: Hospital of the University of Pennsylvania


American Physiological Society, National American Society of Anesthesiologists, National American Society of Regional Anesthesia, National International Anesthesia Research Society, International International Association for the Study of Pain, International Pennsylvania Society of Anesthesiologists, Local

Hospital Affiliation

Dr. Mardini is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Anti-inflammatory drugs, cyclooxygenases ,prostaglandins, mechanisms of pain

Selected Publications:

Barnett RE, Fish D, Katragadda R, Mardini IA, O'Grady TJ: A preemptice approach to stop postoperative pain. A symposium Contemporary Surgery 59 (12) : 559-566,2003.

Aksoy Mark O, Mardini Issam A, Yang Yi, Bin Wei, Zhou Shuangwen, Kelsen Steven G: Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system of human airway epithelium. The Journal of allergy and clinical immunology 109 (3): 491-7,2002.

McAdam B F, Mardini I A, Habib A, Burke A, Lawson J A, Kapoor S, FitzGerald G A: Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. The Journal of clinical investigation 105 (10): 1473-82,2000.

McAdam B F, Catella-Lawson F, Mardini I A, Kapoor S, Lawson J A, FitzGerald G A: Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proceedings of the National Academy of Sciences of the United States of America 96 (1): 272-7,1999.

Kelsen S G, Higgins N C, Zhou S, Mardini I A, Benovic J L: Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. American journal of respiratory and critical care medicine 152 (6 Pt 1): 1774-83,1995.

Kelsen S G, Zhou S, Anakwe O, Mardini I, Higgins N, Benovic J L: Expression of the beta-adrenergic receptor-adenylylcyclase system in basal and columnar airway epithelial cells. The American journal of physiology 267 (4 Pt 1): L456-63,1994.

Mardini I A, Higgins N C, Zhou S, Benovic J L, Kelsen S G: Functional behavior of the beta-adrenergic receptor-adenylyl cyclase system in rabbit airway epithelium. American journal of respiratory cell and molecular biology 11 (3): 287-95,1994.

Kelsen S G, Sexauer W P, Mardini I A, Criner G J: The comparative effects of elastase-induced emphysema on costal and crural diaphragm and parasternal intercostal muscle contractility. American journal of respiratory and critical care medicine 149 (1): 168-73,1994.

Kelsen S G, Bao S, Thomas A J, Mardini I A, Criner G J: Structure of parasternal intercostal muscles in the adult hamster: topographic effects. Journal of applied physiology (Bethesda, Md. : 1985) 75 (3): 1150-4,1993.

Kelsen S G, Mardini I A, Zhou S, Benovic J L, Higgins N C: A technique to harvest viable tracheobronchial epithelial cells from living human donors. American journal of respiratory cell and molecular biology 7 (1): 66-72,1992.

Academic Contact Info

Department of Anesthesiology and Critical Care
3400 Spruce Street

Philadelphia, PA 19104
Phone: (610) 416-4145
Patient appointments: 800-789-7366 (PENN)

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