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Irving Nachamkin, DrPH, MPH

Irving Nachamkin, DrPH, MPH Pathologist

Associate Director, Clinical Microbiology Laboratory
Director, Division of Laboratory Medicine
Laboratory Director, HUP, Radnor, and Rittenhouse
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Nachamkin is a Penn Medicine employed physician.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Description of Clinical Expertise

I am currently Director of the Division of Laboratory Medicine at the Hospital of the University of Pennsylvania. I also am Associate Director of the Clinical Microbiology Laboratory. My areas of expertise include most areas of clinical microbiology. I have particular interests in the diagnosis of gastrointestinal infections.

Practice Locations and Appointments

Education and Training

Graduate School: University of North Carolina at Chapel Hill


American Academy of Microbiology, International American Association for Clinical Chemistry, International American Society for Microbiology, International American Society of Clinical Pathologists, National Association for Molecular Pathology, National Eastern Pennsylvania Branch, American Society for Microbiology, Local Food and Drug Administration, Microbiological Devices Review Panel, National Infectious Diseases Society of America, National The Society for Healthcare Epidemiology of America, National

Hospital Affiliation

Dr. Nachamkin is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

I have a special interest in Campylobacter and other gastrointestinal infections, with a focus on diagnostics, antibiotic resistance, and association of Campylobacter with Guillain-Barre Syndrome. My lab is also involved in several collaborative studies with Prof Lautenbach in the SOM, examining risk factors for development of antimicrobial resistant infections in hospitalized patients and in the community. Other areas of interest include diagnostic microbiology, molecular diagnostic microbiology, cost-effectiveness of laboratory testing.

Selected Publications:

Fitzgerald C, Patrick M, Gonzalez A, Akin J, Polage C, Wymore K, Gillim-Ross L, Xavier K, Sadlowski J, Monahan J, Hurd S, Dahlberg S, Jerris R, Watson R, Santovenia M, Mitchell D, Harrison C, Tobin-D'Angelo M, DeMartino M, Pentella M, Leonard C, Razaq J, Jung C, Achong-Bowe R, Evans Y, Jain D, Juni B, Leano F, Robinson R, Smith S, Gittelman R, Garrigan C, Nachamkin I and Campylobacter Diagnostics Study Working Group: Multicenter evaluation of clinical diagnostic methods for detection and isolation of Campylobacter spp. from stool. J Clin Microbiol 54 : 1209-1215,2016.

Kelly BJ, Lautenbach E, Nachamkin I, Coffin SE, Gerber JS, Fuchs B, Garrigan C, Han X, Bilker WB, Wise J, Tolomeo P, Han JH for the CDC Prevention Epicenters Program: Combined biomarkers discriminate a low likelihood of bacterial infection among surgical intensive care unit patients with suspected sepsis Diag Microbiol Infect Dis 85 : 109-15,2016.

Han J., Nachamkin I., Coffin S., Gerber J., Fuchs B., Garrigan C., Han X., Bilker W., Wise J., Tolomeo P., Lautenbach E.: Use of a combination biomarker algorithm to identify medical intensive care unit patients with suspected sepsis at very low likelihood of bacterial infection Antimicrobial Agents Chemother 59 (10): 6494-6500,2015.

Bartsch SM, Umsheid CA, Nachamkin I, Hamilton K, Lee BY.: Comparing the economic and health benefits of different approaches to diagnosing Clostridium difficult infection Clin Microbiol Infect 21 (1): 77.e1-9,2015.

Sloan CE, Bernard S, Nachamkin I.: Appropriateness of Expectorated Sputum Cultures in the Hospital Setting Diag Microbiol Infect Dis 83 (1): 74-6,2015.

Alby K., Nachamkin I.: Gastrointestinal Infections Microbiology Spectrum 4 (3): doi:10.1128 /microbiolspec.DMIH2-0005-2015,2016.

Cluzet VC, Gerber JS, Nachamkin I, Metlay JP, Zaoutis TE, Davis MF, Julian KG, Royer D, Linkin DR, Coffin SE, Margolis DJ, Hollander JE, Mistry RD, Gavin LJ, Tolomeo P, Wise JA, Wheeler MK, Bilker WB, Han X, Hu B, Fishman NO, Lautenbach E.: Duration of Colonization and Determinants of Earlier Clearance of Colonization with Methicillin-Resistant Staphylococcus aureus Clin Infect Dis 60 (10): 1489-96,2015.

Cluzet VC., Lautenbach E., Nachamkin I., Cary MS., Fishman NO., Morales K., Linkin DR.: Risk factors for gyrA and parC mutations in Pseudomonas aeruginosa Infect Cont Hosp Epidemiol 36 (4): 387-93,2015.

Fitzgerald, C. and I. Nachamkin: Campylobacter and Arcobacter Chapter 56, Manual of Clinical Microbiology, 11th edition : 998-1012,2015.

Rattanaumpawan P., Nachamkin I., Bilker WB., Roy JA., Metlay JP., Zaoutis TE., Lautenbach E.: Risk factors for ambulatory urinary tract infections caused by high MIC-fluoroquinolone susceptible E. coli in women: results from a large case-control study J Antimicrob Chemother 70 (5): 1547-51,2015.

Misic A., David MF., Tyldsley AS, Hodkinson BP, Tolomeo P, Hu B., Nachamkin I, Lautenbach E, Morris DO., Grice EA.: The shared microbiota of humans and companion animals as evaluated from Staphylococcus carriage sites Microbiome 3 (2): doi: 10.1186/s40168-014-0052-7,2015.

Sedrak M., Ziemba J., Murray D., Tsypenyuk B., Mincarelli D., Danoski D, Nachamkin I., Dine J., Myers JS.: Less is more: engaging residents and advanced practioners in a performance improvement project to reduce overutilization of daily labs at the Hospital of the University of Pennsylvania 2015 ACGME Annual Educational Conference, San Diego, California, February 26 - March 1, 2015 : 2015.

Cluzet VC, Nachamkin I., Tolomeo P., Lautenbach E.: Prevalence and epidemiology of murpirocin resistance among those colonized with MRSA in the community. ID Week (IDSA, SHEA), Oct 8-12, 2014, Philadelphia : 2014.

Garrigan C, Attela A, Poly F, Guerry P, Nachamkin I: Distribution of Campylobacter jejuni capsular types, 2007-2012, Philadelphia, PA Diag Microbiol Infect Dis 80 : 204-206,2014.

Barbarin, A.M., Hu, B., Nachamkin, I., Levy, M.Z.: Colonization of Cimex lextularius with methicillin-resistant Staphylococcus aureus Environ. Microbiol. 16 (5): 1222-24,2014.

Han J., Johnston B., Nachamkin I., Tolomeo P., Bilker W., Mao X., Clabots C., Johnson J., Lautenbach E.: Clinical and Molecular Epidemiology of Escherichia coli Sequence Type 131 (ST131) among Hospitalized Patients Colonized Intestinally with Fluoroquinolone-Resistant E. coli Antimicrob Agents Chemother 58 : 7003-6,2014.

Nachamkin I: Laboratory Developed Tests (LDTs) Pepper Talk (blog) :,2015.

Han JH, Bilker WB, Nachamkin I, Tolomeo P, Mao X, Fishman NO, Lautenbach E: Impact of Antibiotic Use during Hospitalization on the Development of Gastrointestinal Colonization with Escherichia coli with Reduced Fluoroquinolone Susceptibility Infect Control Hosp Epidemiol 34 (10): 1070-1076,2013.

Han J., Bilker W., Nachamkin I., Zaoutis T., Coffin S., Linkin DR., Hu B., Tolomeo P., Fishman N., Lautenbach E.: The Effect of a Hospital-Wide Urine Culture Screening Intervention on the Incidence of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Species Infect Control Hosp Epidemiol 34 : 1160-1166,2013.

Han JH, Nachamkin I, Tolomeo P, Mao X, Bilker WB, Lautenbach E: Temporal Changes in Resistance Mechanisms in Colonizing Escherichia coli Isolates with Reduced Susceptibility to Fluoroquinolones Diag Microbiol Infect Dis 76 : 491-496,2013.

View all publications

Academic Contact Info

Department of Pathology and Laboratory Medicine
Room 7-046 Founders Pavilion (Lab Administration)
Hospital of the University of Pennsylvania
3400 Spruce Street

Philadelphia, PA 19104-4283
Phone: (215) 662-3435
Fax: (215) 349-5090

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