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George Zotalis, MD

George Zotalis, MD Physician

Clinical Assistant Professor of Medicine

Languages spoken:

  • Greek

Dr. Zotalis is employed by Penn Medicine.

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Clinical Specialties


  • Internal Medicine

Programs & Centers:

Board Certification:

  • Internal Medicine, 2010
  • Pathology - Anatomic Pathology, 1998

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Aristotelian University of Thessaloniki
Residency: Strong Memorial Hospital - University of Rochester
Fellowship: Geisinger Hospital
Residency: Geisinger Hospital

Hospital Affiliation

Dr. Zotalis is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Selected Publications:

Brown RE, Zotalis G, Zhang PL: Morphoproteomic confirmation of a constitutively activated mTOR pathway in high grade prostatic intraepithelial neoplasia and prostate cancer. Int J Clin Exp Pathol 1 (4): 333-42,2008.

Zotalis G, GC Wood: Constitutive activation of mammalian Target of Rapamycin (mTOR) and p70S6k in prostate cancer. Modern Pathology 19 (170A): 2006.

Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE: NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res (415 Suppl): S75-85,2003.

Rodríguez-Rodríguez L, Sancho-Torres I, Mesonero C, Gibbon D G, Shih WJ: The CD44 receptor is a molecular predictor of survival in ovarian cancer. Med Oncol 20 (3): 255-63,2003.

Tsingotjidou A S, Zotalis G, Jackson KR, Sawyers C, Puzas JE, Hicks DG, Reiter R: Development of an animal model for prostate cancer cell metastasis to adult human bone Anticancer research 21 (2A): 971-8,2001.

Zotalis G, O'Malley S, Schwarz EM, O'Keefe RJ, Rosier RN: NF-KappaB Signaling and Cytokines Implicated in Metastasis of Prostatic Carcinoma to Bone. Lab Invest 80 (202A): 2000.

Kudrick F, Zotalis G, Hicks DG, Puzas Je: MMP-3 expression as prognostic factor in soft tissue sarcomas. URCC 4th Annual Scientific Meeting, Rochester, NY : 1999.

Gordon AH, Mollano AV, Li AP, Andela V, Zotalis G, Rosier RN, Schwarz EM, Romano P, O'Keefe RJ: NF-KappaB signaling controls cytokine secretion and associated bone resorptive capacity of breast cancer cells. J Bone Min Res 14 (S153): 1999.

Ronchetti P, Levine BP, Zotalis G: A significant difference in the immunohistochemical expression of MMP-3 and MMP-9 in active Dupuytren's and normal palmar fascia fibroblasts. American Society of Surgery of the Hand Annual Meeting, Boston, MA : 1999.

Jyotheeswaran S, Zotalis G, Penmetsa P, Levea CM, Schoeniger LO: A newly recognized entity: intraductal "oncocytic" papillary neoplasm of the pancreas Am J Gastroenterol 93 (12): 2539-43,1998.

Academic Contact Info

Penn Medicine Radnor
250 King Of Prussia Rd

Radnor, PA 19087
Patient appointments: 800-789-7366 (PENN)