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George Cotsarelis, MD

George Cotsarelis, MD Physician

Chair, Department of Dermatology Milton Bixler Hartzell Professor of Dermatology

Languages spoken:

  • Greek

Dr. Cotsarelis is employed by Penn Medicine.

About Dr. George Cotsarelis

Recognized by America's Top Doctors, 2007, 2008, 2012 - 2018

Recognized by Best Doctors in America 2005 - 2018

Recognized in Philadelphia magazine's May 2004, 2005, 2007, 2010, 2018, 2019 Top Docs issues

Recognized by Suburban Life magazine's "Top Physicians 2010" issue

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Dermatology

Programs & Centers:

Board Certification:

  • Dermatology, 1992

Clinical Expertise:

  • Acanthosis Nigricans
  • Alopecia Areata
  • Dandruff
  • Dermatitis
  • Dyskeratosis Follicularis
  • Female Pattern Baldness
  • Folliculitis
  • Furuncle
  • Glomangioma
  • Glomus Tumor
  • Hair Diseases
  • Hair Loss (Alopecia Areata)
  • Head Cyst
  • Head Lump
  • Hirsutism
  • Hypertrichosis
  • Hypertrichosis of the Eyelid
  • Hypotrichosis of Eyelid
  • Ingrown Hair
  • Keratosis Pilaris
  • Lichen Planus
  • Male Pattern Baldness
  • Pseudofolliculitis Barbae
  • Scalp Disorders
  • Scalp Psoriasis
  • Seborrheic Dermatitis
  • Seborrheic Eczema
  • Shingles
  • Skin Biopsy
  • Skin Examination
  • Telogen Effluvium
  • Tinea Capitis
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Geisinger Hospital
Fellowship: Hospital of the University of Pennsylvania
Residency: Hospital of the University of Pennsylvania


American Academy of Dermatology, National British Medical Research Council, International Dermatology Foundation Executive Committee, National Fellow, American Academy of Dermatology, National International Society for Stem Cell Research, International Interurban Clinical Club, Local Member, American Dermatological Association, National Member, American Society for Clinical Investigation, National Member, Association of American Physicians, National Member, Interurban Clinical Club, National NAAF Grant Reviewer, National National Institutes of Health, National North American Hair Research Society, National Pennsylvania Medical Society and Philadelphia County Medical Society, Local Philadelphia Dermatological Society, Local Singapore National Medical Research Council, Ministry of Health, International Society for Investigative Dermatology, National Swiss National Science Foundation, International Welcome Trust Grant Reviewer, National Wound Healing Society, National

Hospital Affiliation

Dr. Cotsarelis is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

stem cells
hair follicle
skin cancer

Selected Publications:

Garza, L.A., Yang, C.C., Zhao, T., Blatt, H.B., Lee, M., He, H., Stanton, D.C., Carrasco, L., Spiegel, J.H., Tobias, J.W, Cotsarelis, G.: Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest 121 (2): 613-622,2011.

Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S.E. Cotsarelis, G.: Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 447 : 316-321,2007.

Fan, C., Luedtke, M.A., Prouty, S.M., Burrows, M., Kollias, N., Cotsarelis, G.: Characterization and quantification of wound-induced hair follicle neogenesis using in vivo confocal scanning laser microscopy. Skin Research and Technology 17 (4): 387-97,2011.

*Ito, M., *Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R., Cotsarelis, G. *equal contributors: Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nature Medicine 11 : 1351-1354,2005.

*Morris, R., *Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J., Sawicki, J., Cotsarelis, G., *equal contributors: Capturing and profiling hair follicle stem cells. Nature Biotechnology 22 : 411-417,2004.

Trempus, C.S., Dang, H., Humble, M.M., Wei, S.J., Gerdes, M.J., Morris, R.J., Bortner, C.D., Cotsarelis, G., Tennant, R.W.: Comprehensive Microarray Transcriptome Profiling of CD34-Enriched Mouse Keratinocyte Stem Cells. J Invest Dermatol 127 : 2904-7,2007.

Trempus, C.S., Morris, R.J., Ehinger, M., Elmore, A., Bortner, C.D., Ito, M., Cotsarelis, G., Nijhof, J.G., Peckham, J., Flagler, N., Kissling, G., Humble, M.M., King, L.C., Adams, L.D., Desai, D., Amin, S., Tennant, R.W.: CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res 67 : 4173-81,2007.

Endo, M., Zoltick, P.W., Peranteau, W.H., Radu, A., Muvarak, N., Ito, M., Yang, Z., Cotsarelis, G., Flake, A.W.: Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter. Mol Ther 16 : 131-7,2008.

Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D., Albelda, S., Cotsarelis, G.: The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Science 111 : 3179-3188,1998.

Kantor, J., Jay, L., Brooks, D., Cotsarelis, G.: Decreased Serum Ferritin is Associated with Alopecia in Women. J Invest Dermatol 121 : 963-968,2003.

Liu, Y., Lyle, S., Solky, B., Cotsarelis, G.: Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol 121 : 985-988,2003.

Cotsarelis, G., Sun, T., Lavker, R.: Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61 : 1329-1337,1990.

Hanakawa, Y., Li, H., Lin, C., Stanley, J.R., Cotsarelis, G.: Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle. J Invest Dermatol 123 (5): 817-822,2004.

Xu, X., Lyle, S., Liu, Y., Solky, B., Cotsarelis, G.: Differential expression of cyclin D1 in the human hair follicle. Am J Pathol 163 : 969-978,2003.

Trempus, C., Morris, R., Bortner, C., Cotsarelis, G., Faircloth, R., Reece, J., Tennant, W.: Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol 120 : 501-511,2003.

Cotsarelis, G., Cheng, S.-Z., Dong, G., Sun, T., Lavker, R.: Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 57 : 201-209,1989.

Academic Contact Info

1053 Biomedical Research Building
Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)

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