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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Penn Neuroscience Center, Perelman Center for Advanced Medicine
South Pavilion, 2nd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
I study human cortical organization for vision, and how this organization is altered by neurologic and ophthalmologic disease. Human visual cortex is composed of early, “retinotopically” organized visual areas, as well as more specialized, “categorical” areas that process specific visual features (such as facial appearance). My work has varied along two dimensions within this research space: scale and perturbation. I have examined the organization of visual cortex from its large-scale, anatomical arrangement to the precise and subtle form of population neural coding for object features. These studies at different scales of cortical organization have further been conducted both in healthy controls as well as in patients for whom visual function has been perturbed by retinal disease or cerebral dysfunction. I make use of a variety of scientific techniques, although the majority of my research uses BOLD fMRI, which is a non-invasive measure of neural activity in human participants.
Patterson Gentile C, Aguirre GK: A neural correlate of visual discomfort from flicker Journal of Vision 20 (7): 2020.
McAdams H, Kaiser EA, Igdalova A, Haggerty EB, Cucchiara B, Brainard DH, Aguirre GK: Selective amplification of ipRGC signals accounts for interictal photophobia in migraine Proceedings of the National Academy of Sciences of the United States of America 117 (29): 1730-17329,2020.
Grewal JS, Gloe T, Hegedus J, Bitterman K, Billings BK, Chengetanai S, Bentil S, Wang VX, Ng JC, Tang CY, Geletta S, Wicinski B, Bertelson M, Tendler BC, Mars RB, Aguirre GK, Rusbridge C, Hof PR, Sherwood CC, Manger PR, Spocter MA: Brain gyrification in wild and domestic canids: Has domestication changed the gyrification index in domestic dogs? Journal of Comparative Neurology : 2020.
M Cieslak, ..., GK Aguirre, ..., TD Satterthwaite: QSIPrep: Robust workflows for preprocessing and reconstructing diffusion MRI Nature Methods : 2020.
NF Darwich, JM Phan, B Kim, E Suh, JD Papatriantafyllou, L Changolkar, AT Nguyen, C O’Rourke, Z He, S Porta, GS Gibbons, KC Luk, SG Papageorgiou, M Grossman, L Massimo, DJ Irwin, CT McMillan, IM Nasrallah, C Toro, GK Aguirre, VM Van Deerlin, EB Lee: Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau Science : 2020.
M Chen, J Nofziger, R Datta, JC Gee, J Morgan, GK Aguirre: The influence of axial length upon the retinal ganglion cell layer of the human eye TVST : 2020.
R Cooper, GK Aguirre, J Morgan: Fully-Automated Estimation of Spacing and Density for Retinal Mosaics Translational Vision Science & Technology : 2020.
C Workman, S Humphries, F Hartung, GK Aguirre, J Kable, A Chatterjee: Morality is in the eye of the beholder: Unpacking the neurocognitive basis of the “anomalous-is-bad” stereotype (submitted) : 2020.
Cooper RF, Aguirre GK, Morgan JIW: Fully Automated Estimation of Spacing and Density for Retinal Mosaics Translational Vision Science & Technology 8 (5): 2019.
Kaiser EA, Igdalova A, Aguirre GK, Cucchiara B: A web-based, branching logic questionnaire for the automated classification of migraine Cephalalgia 39 (10): 1257-1266,2019.
Department of Neurology3400 Spruce Street
Patient appointments: 800-789-7366