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Frederic Bibollet-Ruche, PhD Researcher

Research Assistant Professor of Medicine

Dr. Bibollet-Ruche is employed by Penn Medicine.

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Clinical Specialties

Programs & Centers:

Hospital Affiliation

Dr. Bibollet-Ruche is employed by Penn Medicine.


Description of Research Expertise:

NGS (Next Generation Sequencing)
Molecular Biology
Cellular Biology

Selected Publications:

Barbian Hannah J, Connell Andrew Jesse, Avitto Alexa N, Russell Ronnie M, Smith Andrew G, Gundlapally Madhurima S, Shazad Alexander L, Li Yingying, Bibollet-Ruche Frederic, Wroblewski Emily E, Mjungu Deus, Lonsdorf Elizabeth V, Stewart Fiona A, Piel Alexander K, Pusey Anne E, Sharp Paul M, Hahn Beatrice H: CHIIMP: An automated high-throughput microsatellite genotyping platform reveals greater allelic diversity in wild chimpanzees. Ecology and evolution 8 (16): 7946-7963,2018.

Plenderleith Lindsey J, Liu Weimin, MacLean Oscar A, Li Yingying, Loy Dorothy E, Sundararaman Sesh A, Bibollet-Ruche Frederic, Learn Gerald H, Hahn Beatrice H, Sharp Paul M: Reply to Forni et al., "Multiple Selected Changes May Modulate the Molecular Interaction between RH5 and Primate Basigin". mBio 9 (3): 2018.

Wetzel Katherine S, Yi Yanjie, Yadav Anjana, Bauer Anya M, Bello Ezekiel A, Romero Dino C, Bibollet-Ruche Frederic, Hahn Beatrice H, Paiardini Mirko, Silvestri Guido, Peeters Martine, Collman Ronald G: Loss of CXCR6 coreceptor usage characterizes pathogenic lentiviruses. PLoS pathogens 14 (4): e1007003,2018.

Plenderleith Lindsey J, Liu Weimin, MacLean Oscar A, Li Yingying, Loy Dorothy E, Sundararaman Sesh A, Bibollet-Ruche Frederic, Learn Gerald H, Hahn Beatrice H, Sharp Paul M: Adaptive Evolution of RH5 in Ape species of the Subgenus. mBio 9 (1): 2018.

Barbian Hannah J, Jackson-Jewett Raven, Brown Corrine S, Bibollet-Ruche Frederic, Learn Gerald H, Decker Timothy, Kreider Edward F, Li Yingying, Denny Thomas N, Sharp Paul M, Shaw George M, Lifson Jeffrey, Acosta Edward P, Saag Michael S, Bar Katharine J, Hahn Beatrice H: Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee. Retrovirology 14 (1): 35,2017.

Richard Jonathan, Prévost Jérémie, von Bredow Benjamin, Ding Shilei, Brassard Nathalie, Medjahed Halima, Coutu Mathieu, Melillo Bruno, Bibollet-Ruche Frédéric, Hahn Beatrice H, Kaufmann Daniel E, Smith Amos B, Sodroski Joseph, Sauter Daniel, Kirchhoff Frank, Gee Katrina, Neil Stuart J, Evans David T, Finzi Andrés: BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity. Journal of virology 91 (11): 2017.

Mack Katharina, Starz Kathrin, Sauter Daniel, Langer Simon, Bibollet-Ruche Frederic, Learn Gerald H, Stürzel Christina M, Leoz Marie, Plantier Jean-Christophe, Geyer Matthias, Hahn Beatrice H, Kirchhoff Frank: Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain. Journal of virology 91 (6): 2017.

Iyer Shilpa S, Bibollet-Ruche Frederic, Sherrill-Mix Scott, Learn Gerald H, Plenderleith Lindsey, Smith Andrew G, Barbian Hannah J, Russell Ronnie M, Gondim Marcos V P, Bahari Catherine Y, Shaw Christiana M, Li Yingying, Decker Timothy, Haynes Barton F, Shaw George M, Sharp Paul M, Borrow Persephone, Hahn Beatrice H: Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness. Proceedings of the National Academy of Sciences of the United States of America 114 (4): E590-E599,2017.

Cadena Cristhian, Stavrou Spyridon, Manzoni Tomaz, Iyer Shilpa S, Bibollet-Ruche Frederic, Zhang Weiyu, Hahn Beatrice H, Browne Edward P, Ross Susan R: The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model. Retrovirology 13 (1): 45,2016.

Etienne L, Bibollet-Ruche F, Sudmant PH, Wu LI, Hahn BH, Emerman M: The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys. PLoS pathogens 11 (9): e1005149,2015.

Academic Contact Info

University of Pennsylvania
423A Johnson Pavilion
3610 Hamilton Walk

Philadelphia, PA 19104
Phone: (215) 573-6462