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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Research Interests:Genomic and metagenomic approaches to understand cutaneous host-microbe interactions in health and disease.Keywords:host-microbe interactions, skin microbiome, metagenomics, wound healing, chronic woundsResearch Description:The skin is a formidable barrier and the first line of defense against the external environment. The skin is also host to myriad microbes (the "microbiome") including diverse communities of bacteria, fungi, viruses, and even arthropods. Our research uses an interdisciplinary approach to understand how these microbial communities coexist and interact with the host at the skin surface, in health and disease. We hypothesize that disruptions in the dynamic interplay between the skin barrier, the microbiome, and the cutaneous defense response may in part be responsible for inflammatory and infectious skin disorders. One area of particular focus is impaired wound healing, especially in the context of diabetes, and how microbes modulate wound repair processes and clinical outcomes. To address these questions, our lab uses multiple approaches, including genomic and metagenomic sequencing of clinical specimens (16S ribosomal RNA gene sequencing, shotgun metagenomic sequencing, whole genome sequencing, RNA-seq), microbiological and skin tissue culture, and in vivo murine and porcine skin and wound models.
Bradley Charles W, Lee Fiona F, Rankin Shelley C, Kalan Lindsay R, Horwinski Joseph, Morris Daniel O, Grice Elizabeth A, Cain Christine L: The otic microbiota and mycobiota in a referral population of dogs in eastern USA with otitis externa. Veterinary dermatology : 2020.
Deusenbery Carly B, Kalan Lindsay, Meisel Jacquelyn S, Gardner Sue E, Grice Elizabeth A, Spiller Kara L: Human macrophage response to microbial supernatants from diabetic foot ulcers. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 27 (6): 598-608,2019.
Beck James Peter, Grogan Max, Bennett Brian T, Jeyapalina Sujee, Agarwal Jay, Bartow-McKenney Casey, Bugayev Julia, Kubiak Erik, Sinclair Sarina, Grice Elizabeth: Analysis of the Stomal Microbiota of a Percutaneous Osseointegrated Prosthesis: A Longitudinal Prospective Cohort Study. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 37 (12): 2645-2654,2019.
Kalan Lindsay R, Meisel Jacquelyn S, Loesche Michael A, Horwinski Joseph, Soaita Ioana, Chen Xiaoxuan, Uberoi Aayushi, Gardner Sue E, Grice Elizabeth A: Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy. Cell Host & Microbe 25 (5): 641-655.e5,2019.
Zheng Qi, Bartow-McKenney Casey, Meisel Jacquelyn S, Grice Elizabeth A: HmmUFOtu: An HMM and phylogenetic placement based ultra-fast taxonomic assignment and OTU picking tool for microbiome amplicon sequencing studies. Genome Biology 19 (1): 82,2018.
Bartow-McKenney Casey, Hannigan Geoffrey D, Horwinski Joseph, Hesketh Patrick, Horan Annamarie D, Mehta Samir, Grice Elizabeth A: The microbiota of traumatic, open fracture wounds is associated with mechanism of injury. Wound Repair and Regeneration 26 (2): 127-135,2018.
Fiala Catherine A, Abbott Linda I, Carter Cheryl D, Hillis Stephen L, Wolf Jessica S, Schuster Meghan, Dulski Rachel, Grice Elizabeth A, Rakel Barbara A, Gardner Sue E: Severe pain during wound care procedures: A cross-sectional study protocol. Journal of Advanced Nursing : 2018.
SanMiguel Adam J, Meisel Jacquelyn S, Horwinski Joseph, Zheng Qi, Bradley Charles W, Grice Elizabeth A: Antiseptic Agents Elicit Short-Term, Personalized, and Body Site-Specific Shifts in Resident Skin Bacterial Communities. The Journal of Investigative Dermatology 138 (10): 2234-2243,2018.
Loesche Michael A, Farahi Kamyar, Capone Kimberly, Fakharzadeh Steven, Blauvelt Andrew, Duffin Kristina Callis, DePrimo Samuel E, Muñoz-Elías Ernesto J, Brodmerkel Carrie, Dasgupta Bidisha, Chevrier Marc, Smith Kevin, Horwinski Joseph, Tyldsley Amanda, Grice Elizabeth A: Longitudinal Study of the Psoriasis-Associated Skin Microbiome during Therapy with Ustekinumab in a Randomized Phase 3b Clinical Trial. The Journal of Investigative Dermatology 138 (9): 1973-1981,2018.
Meisel Jacquelyn S, Sfyroera Georgia, Bartow-McKenney Casey, Gimblet Ciara, Bugayev Julia, Horwinski Joseph, Kim Brian, Brestoff Jonathan R, Tyldsley Amanda S, Zheng Qi, Hodkinson Brendan P, Artis David, Grice Elizabeth A: Commensal microbiota modulate gene expression in the skin. Microbiome 6 (1): 20,2018.
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