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Despina Kontos, PhD

Despina Kontos, PhD Researcher

Director of the Computational Breast Imaging Group (CBIG) Associate Professor of Radiology

Dr. Kontos is employed by Penn Medicine.

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Abramson Cancer Center, Breast Cancer Program, University of Pennsylvania, Philadelphia PA, Local American Society of Clinical Oncology (ASCO), International Are You Dense Inc., National Breast Cancer Alliance External Reviewer, Exceptional Project Grants, National Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia PA, Local Institute for Biomedical Informatics (IBI), University of Pennsylvania, Philadelphia, PA, Local Institute for Translational Medicine and Therapeutics (ITMAT), School of Medicine (SOM), University of Pennsylvania, Philadelphia PA, Local Medical Image Computing and Computer Assisted Intervention (MICCAI) Society, International Member of the Institute of Electrical and Electronics Engineers (IEEE), International National Institutes of Health (NIH)/Center for Scientific Review (CSR), National National Institutes of Health (NIH)/Center for Scientific Review (CSR), National National Institutes of Health (NIH)/Center for Scientific Review (CSR), National National Institutes of Health (NIH)/Center for Scientific Review (CSR), ZCA1 RPRB-B (O1) National Cancer Institute (NIH) Special Emphasis Panel for K-Award grant reviews., National NIH/NCI Population-Based Research Optimizing Screening through Personalized Regimens (PROSPR) Network, Breast Working Group, National Philadelphia Family Pride (PFP), non-profit organization to build community for LGBTQ families in the greater Philadelphia region through advocacy, education and family-centered events., Local Radiological Society of North America (RSNA), International The Avon Foundation for Women, Breast Cancer Research Program, Grant Review Panel, National

Hospital Affiliation

Dr. Kontos is employed by Penn Medicine.


Description of Research Expertise:

Biomedical image analysis; Quantitative imaging biomarkers; Pattern recognition; Identification, characterization and validation of imaging biomarkers; Evaluation of genotype to phenotype associations via imaging; Integrated diagnostics; Risk prediction; Personalized screening, prognostication and treatment of breast cancer.

Selected Publications:

E.F. Conant, B.M. Keller, L. Pantalone, A. Gastounioti, E.S. McDonald, D. Kontos: Agreement between Breast Percent Density Estimation from Standard versus Synthetic Digital Mammograms: Results from a Large Screening Cohort Using Automated Measures Radiology 283 (3): 673-680,2017.

B.L. Sprague, E.F. Conant, T. Onega, M.P. Garcia, E.F. Beaber, S.D. Herschorn, C.D. Lehman, A.N.A. Tosteson, R. Lacson, M.D. Schnall, D. Kontos, J.S. Haas, D.L. Weaver, W.E. Barlow, on behalf of the PROSPR consortium: Variation in mammographic breast density assessments among radiologists in clinical practice: Findings from a multicenter observational study Annals of Internal Medicine 165 (7): 457-464,2016.

L. Chen, S. Ray, B.M. Keller, S. Pertuz, E.S. McDonald, E.F. Conant, D. Kontos: The Impact of Acquisition Dose on Quantitative Breast Density Estimation with Digital Mammography: Results from ACRIN PA 4006 Radiology 280 (3): 693-700,2016.

A.M. McCarthy, B.M. Keller, L.M. Pantalone, M-K. Hsieh, M. Synnestvedt, E.F. Conant, K. Armstrong, D. Kontos: Racial differences in quantitative measures of area and volumetric breast density Journal of the National Cancer Institute (JNCI) 108 (10): djw104 doi: 10.1093/jnci/djw104,2016.

S. Pertuz, E. McDonald, S.P. Weinstein, E.F. Conant, D. Kontos: Fully-automated quantitative estimation of volumetric breast density from digital breast tomosynthesis images: Preliminary results and comparison with digital mammography and magnetic resonance imaging Radiology 279 (1): 65-74,2016.

B.M. Keller, J. Chen, D. Daye, E.F. Conant, D. Kontos: Preliminary evaluation of the publicly available Laboratory for Breast Radiodensity Assessment (LIBRA) software tool: Comparison of fully-automated area and volumetric density measures in a case-control study with digital mammography Breast Cancer Research 17 (1): 117; doi: 10.1186/s13058-015-0626-8.,2015.

S. Wu, S.P. Weinstein, M.J. Deleo, E.F. Conant, J. Chen, S.M. Domchek, D. Kontos: Quantitative assessment of Background Parenchymal Enhancement in breast MRI predicts response to Risk-Reducing Salpingo-Oophorectomy: Preliminary evaluation in a cohort of BRCA1/2 mutation carriers Breast Cancer Research 17 (67): doi: 10.1186/s13058-015-0577-0,2015.

AM. McCarthy, D. Kontos, M. Synnestvedt, K. Tan, D.F. Heitjan, M. Schnall, E.F. Conant: Screening Outcomes Following Implementation of Digital Breast Tomosynthesis in a General-Population Screening Program Journal of the National Cancer Institute (JNCI) 106 (11): dju316,2014.

A.B. Ashraf, D. Daye, S. Gavenonis, C. Mies, M. Feldman, M. Rosen, D. Kontos: Identification of intrinsic radio-phenotypes for breast cancer tumors: Preliminary associations with gene expression profiles Radiology 272 (2): 374-84,2014.

A. Ashraf, S. Gavenonis, D. Daye, C. Mies, M. Feldman, M.A. Rosen, and D. Kontos: A Multichannel Markov Random Field Framework for Tumor Segmentation with an Application to Classification of Gene Expression-based Breast Cancer Recurrence Risk IEEE Transactions on Medical Imaging 32 (4): 637-48,2013.

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Academic Contact Info

Computational Biomarker Imaging Group (CBIG)
University of Pennsylvania, Department of Radiology
Rm D702 Richards Bldg., 3700 Hamilton Walk

Philadelphia, PA 19104
Phone: (215) 746-4064