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Dean G. Karalis, MD, FACC, FNLA

Dean G. Karalis, MD, FACC, FNLA Physician

Director of Preventive Cardiology, Pennsylvania Hospital

Languages spoken:

  • Greek

Dr. Karalis is a Penn Medicine employed physician.

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Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 1989
  • Internal Medicine, 1987

Clinical Expertise:

  • 3D Echocardiography
  • Acute Coronary Disease
  • Cardiac Stress Tests
  • Cardiology Risk Intervention
  • Consultative Cardiology
  • Diabetic Heart Disease
  • Dizziness
  • Echocardiographic Stress Testing
  • Echocardiography
  • Electrocardiography (ECG or EKG)
  • Heart Attack (Myocardial Infarction)
  • Heart Palpitations
  • High Cholesterol (Hypercholesterolemia)
  • Hyperlipidemia (Hyperlipoproteinemia)
  • Hypertensive Heart Disease
  • Interventional Echocardiography
  • Ischemic Heart Disease (Myocardial Ischemia)
  • Lipid Disorders Management
  • Mitral Stenosis
  • Non-Invasive Cardiac Imaging
  • Non-Surgical Heart Disease Treatment
  • Nuclear Cardiology
  • Nuclear Imaging
  • Nuclear Stress Test
  • Peripheral Artery Disease (PAD)
  • Peripheral Vascular Disease
  • Preventive Heart Care
  • Syncope (Fainting)
  • Treadmill Stress Test

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Albany Medical College of Union University
Residency: NewYork-Presbyterian/Weill Cornell Medical Center
Residency: North Shore University Hospital
Fellowship: Hahnemann University Hospital


American College of Cardiology , National American College of Physicians , National American Medical Association, National Council on Clinical Cardiology, American Heart Association, National National Lipid Association, National Pennsylvania Medical Society, Local Philadelphia Lipid and Atherosclerosis Club, Local

Hospital Affiliation

Dr. Karalis is a Penn Medicine employed physician.

Hospital Privileges:

  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Victor B, Ahedor L, Liu L, Karalis DG.: Women With Coronary Heart Disease Are Less Aggressively Treated With Lipid Lowering Medications Than Men. Presented at the American College of Cardiology 61st Annual Scientific Sessions. March 2012, Chicago IL. J Am Coll Cardiol 2012; 59: E1745. : 2012.

Combination Therapy Not the Intensity of Statin Therapy Improves LDL Goal Attainment in Clinical Practice.: Victor B, Ahedor L, Liu L, Karalis DG. Presented at the Epidemiology and Prevention/ Nutrition, Physical Activity and Metabolism 2012 Scientific Sessions. March 2012, San Diego CA; Circulation 2012; 125: AP195. : 2012.

Smith Jason A, Karalis Dean G, Rosso Andrea L, Grothusen John R, Hessen Scott E, Schwartzman Robert J: Syncope in complex regional pain syndrome. Clinical Cardiology 34 (4): 222-225,2011.

Karalis Dean G, Subramanya Raghunandan Dudda, Hessen Scott E, Liu Longjian, Victor Mark F: Achieving optimal lipid goals in patients with coronary artery disease. The American Journal of Cardiology 107 (6): 886-890,2011.

Subramanya RD, Hessen SH, Longjan L, Victor MF, Karalis DG.: Optimal lipid levels in patients with coronary artery disease in clinical practice. Presented at the 59th Annual Scientific Sessions of the American College of Cardiology Conference. March 2010, Atlanta, Georgia. J Am Coll Cardiol 2010; 55: A51 : 2010.

Mathur G, Karalis DG, Clark A, Cleland JG.: Both high and low cholesterol levels are associated with poor prognosis in patients with left ventricular systolic dysfunction. Presented at the American Heart Association Quality Control Research Conference. May 2010, Washington DC. : 2010.

Watson Pauline D, Joy Parijat S, Nkonde Chileshe, Hessen Scott E, Karalis Dean G: Comparison of bleeding complications with omega-3 fatty acids + aspirin + clopidogrel--versus--aspirin + clopidogrel in patients with cardiovascular disease. The American Journal of Cardiology 104 (8): 1052-1054,2009.

Karalis Dean G: Intensive lowering of low-density lipoprotein cholesterol levels for primary prevention of coronary artery disease. Mayo Clinic Proceedings 84 (4): 345-352,2009.

Watson PD, Joy PS, Nkonde C, Hessen S, Karalis DG.: Does high dose fish oil increase the risk of bleeding in patients taking aspirin and clopidogrel? Presented at the 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in association with the Council on Nutrition, Physical Activity and Metabolism of the American Heart Association. March 2009, Tampa, Florida. Circulation 2009; 119: P234 : 2009.

Karalis Dean G: The role of lipid-lowering therapy in preventing coronary heart disease in patients with type 2 diabetes. Clinical Cardiology 31 (6): 241-248,2008.

Academic Contact Info

Pennsylvania Hospital
700 Spruce Street
Suite 507

Philadelphia, PA 19107
Phone: (267) 479-1480
Fax: (215) 873-0201
Patient appointments: 800-789-7366 (PENN)